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C-C Bond Formation

Carbon-carbon bond formation is a fundamental transformation of synthetic organic chemistry. The ability to elaborate and extend a carbon framework via a series of C-C bond forming reactions is paramount to medicinal chemistry, agrochemical synthesis, and natural product synthesis.

Sigma-Aldrich has a wide breadth of products for traditional C-C bond formations, such as phosphonium salts for Wittig reactions, and phosphonates for Horner-Wadsworth-Emmons (HWE) reactions. These reactions are continually used to create various alkene-containing products.

However, the past 20 years has seen tremendous advances in the synthetic methods available for C-C bond formation. These advances are due to various factors, including the development of robust and reliable protocols for cross-coupling, increased accessibility to various organometallic reagents, and the creation and improvement of stoichiometric reagents which serve to place a specific carbon-containing moiety.

In that last category, Sigma-Aldrich is leading the way with a diverse selection of reagents for trifluoromethylation and difluoromethylation. Many of these reagents can be employed under mild conditions and have broad substrate scope. These new reagents allow for powerful routes to carbon-carbon bond formation. Sigma-Aldrich also carries an extensive array of palladium, ruthenium, and other metal precatalysts and catalysts for various cross-coupling reactions, as well as a diverse selection of boronic acids and derivatives, alkynes, triflates, and halogenated substrates. In addition, we have various catalysts for olefin and alkyne metathesis available for your research.