Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864, this energy-rich and versatile class of compounds has enjoyed considerable interest. In more recent years, completely new perspectives have emerged, notably the use of organic azides for peptide synthesis, combinatorial synthesis, heterocycle synthesis, and the ligation or modification of biopolymers. The most prominent fields of application today are Huisgen 1,3-dipolar azide-alkyne cycloadditions and different variants of the Staudinger ligation. The azido group can also be used as a protecting group for primary amines, especially in sensitive substrates such as complex carbohydrates or peptide nucleic acids (PNA) and coordination compounds, as azides are stable to alkene metathesis conditions.
Sigma-Aldrich is proud to offer you a broad range of organic azides for your research.