Unnatural Amino Acids

Unnatural amino acids, utilized as building blocks, conformational constraints, molecular scaffolds or pharmacologically active products, represent a nearly infinite array of diverse structural elements for the development of new leads in peptidic and non-peptidic compounds. Small-molecule combinatorial libraries containing unnatural amino acid residues already have shown remarkable impact on drug discovery processes. Novel, short-chain peptide ligand mimetics with both enhanced biological activity and proteolytic resistance are drug candidates in today’s pharmaceutical pipelines. Optimized and fine-tuned analogues of peptidic substrates, inhibitors or effectors are also excellent analytical tools for investigating signal transduction pathways or gene regulation.
 

Our fast-growing, innovative line of unnatural amino acids includes:

• b-amino acids (b³ and b²)
• homo-amino acids
• cyclic amino acids
• aromatic amino acids
• Pro and Pyr derivatives
• 3-substituted Alanine derivatives
• Glycine derivatives
• Ring-substituted Phe and Tyr Derivatives
• Linear Core Amino Acids
• Diamino Acids

Vol. 4, No. 5 Unnatural Amino Acids: Tools for Drug Discovery 2.96 MB PDF

Vol. 2, No. 4 Unnatural Amino Acids II 0.69 MB PDF

Vol. 1, No. 5 Unnatural Amino Acids 0.67 MB PDF