JandaJels™

JandaJels™ are novel insoluble supports that contain a flexible tetrahyrdofuran-derived cross-linker (figure 1).

Figure 1

When performing SPOS, this novel structure offers many advantages over other commercially available polystyrene resins, including:¹

• Interior that is more "organic solvent-like" than that of Divinylbenzene cross-linked resins.
• Increased swelling/solvation characteristics in common solvents used in SPOS.
• Increased site accessibility and thus resin functionality.
• Increased homogeneity.

These resins have been utilized in a wide range of applications, from a recyclable polymer-supported catalyst², to the synthesis of phthalide³ and tertiary amine⁴ libraries. Further applications, are currently being investigated.

Superior Swelling characteristics of JandaJels™

Left: Merrifield-1% DVB     Right: JandaJel-Cl

Volume of Swollen Resin (mL/g)

Volumes were measured in syringes equipped with a sintered frit after equilibrating for 1h. The JandaJels^TM did exhibit modest swelling in ethyl ether and 1:1 THF:water. Water, acetonitrile, and ethanol were also examined, but no significant swelling was observed. All resins had dry volumes of approximately 1.5 mL/g

Reference: Toy, P.H. et. Al J. Comb. Chem., submitted for publication, 2000.

For applications of JandaJels^TM resins in solid-phase organic synthesis, see:

1. Toy, P.H.; Janda, K.D. Tetrahedron Lett. 1999, 40, 6329.
2. Toy, P.H. et al. J. Comb. Chem., submitted for publication , 2000.
3. Reger, T.S.; Janda, K.D. J. Am. Chem. Soc., 2000, 122, 6929.
4. Garibay, P., et al. Synlett, 1999, 9, 1438
5. Toy, P.H., et al. Org. Lett., 2000, 2, 2205.

For additional information or application data on the JandaJels^TM and JandaJels^TM resins, or any other resins for SPOS, please contact our Technical Services Department.

JandaJels^TM is a trademark of Sigma-Aldrich Co.