Solvent Center

Anhydrous Solvents

Sigma-Aldrich's offers a full range of high-purity solvents with extremely low water levels specifically manufactured for moisture sensitive Organic and BioTech applications.


Anhydrous Solvents
BioTech Solvents
Sigma-Aldrich Anhydrous & BioTech Solvents Table




Anhydrous Solvents
  Use our anhydrous solvent supplier cross-reference guide to compare grades and packaging options with Sigma-Aldrich quality products. (180 Kb PDF)

Complete list of Anhydrous grade solvents

Water content ranges from typically 10 to 30 ppm and do not require additional drying in your lab due to our low residue levels.


Ideal use in applications requiring extremely low levels of water such as:


Chemical Synthesis

High Throughput Screening

Oligonucleotide Synthesis

Organometallic

Sigma-Aldrich Anhydrous solvents are available in Sure/Seal Bottles and Pure-Pac containers.


Anhydrous 2-Methyltetrahydrofuran - A versatile alternative to Tetrahydrofuran and Dichloromethane

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BioTech Solvents

Complete list of BioTech grade solvents


The BioTech line of solvents is characterized by not only low water content, but also minimal residue and clean UV spectra.


Purified for biotechnology applications such as:

Oligonucleotide Synthesis


Sigma-Aldrich BioTech solvents are available in Sure/Seal Bottles and Pure-Pac containers.

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Sigma-Aldrich Anhydrous & BioTech Solvents Table

Anhydrous Biotech
Acetonitrile  
Purity
Water
100 mL
Residue		 27,100-4
99.8%
< 10 ppm
< 50 ppm
< 0.0005%		   49,444-5
≥99.93%
< 10 ppm
 
<0.0002%		 UV nm
190
210
220
235-400
<0.008 meq/g
<0.0006 meq/g		 Max Abs.
1.000
0.030
0.010
0.005
Titr. Acid
Titr. Base
Buytl acetate  
Purity
Water
Residue		 28,772-5
≥99%
< 50 ppm
< 0.0005%		   49,616-2
99.7%
< 10 ppm
<0.0005%		 UV nm


<0.0016 meq/g		 Max Abs.


Titr. Acid
Carbon tetrachloride  
Purity
Water
100 mL
Residue		 28,911-6
≥99.5%
< 20 ppm
<50 ppm
< 0.0003%		        
1-Chlorobutane  
Purity
Water
100 mL
Residue		 41,425-5
99.5%
< 30 ppm
< 50 ppm
< 0.0005%		   49,617-0
≥99.5%
< 10 ppm

<0.0003%		 UV nm



<0.0016 meq/g		 Max Abs.



Titr. Acid
Chloroform
0.5-1.0% ethanol as stabilizer		  
Purity
Water
100 mL
Residue		 40,176-5
99.7%
< 10 ppm
< 50 ppm
< 0.0005%		   49,618-9
≥99.9%
< 10 ppm

<0.0003%		    
Dichloromethane
50-150 ppm hydrocarbon as stabilizer		  
Purity
Water
100 mL
Residue		 27,099-7
99.0%
< 10 ppm
< 50 ppm
< 0.0005%		   49,445-3
99.9%
< 20 ppm

<0.0003%		 UV nm
235
240
250
260
340-400		 Max Abs.
1.000
0.200
0.050
0.020
0.010
N,N-Diisopropylethylamine  
Purity
Water
Residue		 27,101-2
99.8%
< 50 ppm
< 0.0001%		   49,621-9
99.5%
< 20 ppm 		   
N,N-Dimethylformamide  
Purity
Water
Residue		 22,705-6
99.8%
< 50 ppm
< 0.0005%		   49,448-8
≥99.9%
< 50 ppm
<0.0005%		 UV nm
275
295
310
340-400
<0.0005 meq/g
<0.0003 meq/g		 Max Abs.
0.30
0.10
0.05
0.07
Titr. Acid
Titr. Base
Dimethyl sulfoxide  
Purity
Water
Residue		 27,685-5
≥99.9%
< 50 ppm
< 0.0005%		   49,442-9
99.8%
< 50 ppm
<0.0005%		 UV nm
270
280
295
350-400		 Max Abs.
1.00
0.30
0.10
0.01
1,4-Dioxane  
Purity
Water
100 mL
Residue		 29,630-9
99.8%
< 30 ppm
< 50 ppm
< 0.0003%		        
Ether
1 ppm BHT as stabilzer		  
Purity
Water
100 mL
Residue		 29,608-2
≥ 99.7%
< 30 ppm
< 50 ppm
< 0.0003%		        
Ethyl actate  
Purity
Water
Residue		 27,098-9
99.8%
< 50 ppm
< 0.0005%		   49,451-8
≥99.8%
< 10 ppm
<0.0003%		 UV nm
254
263
275-400
<0.0009 meq/g		 Max Abs.
1.00
0.05
0.01
Titr. Acid
Heptane  
Purity
Water
100 mL
Residue		 24,665-4
99%
< 10 ppm
< 50 ppm
< 0.0005%		   49,452-6
≥99%
< 50 ppm

<0.0002%		 UV nm
197
210
220
230
260-400		 Max Abs.
1.00
0.40
0.15
0.05
0.01
Methanol  
Purity
Water
100 mL
Residue		 32,241-5
99.8%
< 20 ppm
< 50 ppm
< 0.0003%		   49,443-7
99.93%
< 20 ppm

<0.0003%		 UV nm
203
220
230
240
260-400
<0.0003 meq/g
<0.0002 meq/g		 Max Abs.
1.00
0.60
0.15
0.05
0.01
Titr. Acid
Titr. Base
3-Methyl-1-butanol  
Purity
Water
100 mL
Residue		 30,943-5
≥99%
< 30 ppm
< 50 ppm
< 0.0005%		   49,620-0
≥99%
< 50 ppm

<0.0005%		 UV nm


<0.002 meq/g
<0.1%		 Max Abs.


Titr. Acid
Carbonyl
1-Methyl-2-pyrrolidinone  
Purity
Water 		32,863-4
99.5%
< 50 ppm 		  49,449-6
≥99.5%
< 50 ppm 		UV nm
285
300
325
350-400
<0.01% meq/g 		Max Abs.
1.00
0.50
0.10
0.01
Free amines
1-Propanol  
Purity
Water
Residue		 27,954-4
99.7%
< 50 ppm
< 0.0003%		   49,619-7
99.7%

<0.0003%		 UV nm


<0.0004 meq/g 		Max Abs.


Titr. Acid
Pyridine  
Purity
Water
100 mL
Residue		 27,097-0
99.8%
< 30 ppm
< 50 ppm
< 0.0005%		   49,441-0
≥99.9%
< 30 ppm

<0.0003%		 UV nm
<0.001%
<0.0005%
<0.002%
<0.0001% 		Max Abs.
Cl
Cu
NH3
SO4
Tetrahydrofuran
Inhibitor-free		  
Purity
Water
100 mL
Residue		 401757
99.9%
< 20 ppm
< 50 ppm
< 0.0005%		   49,446-1
≥99.9%
< 50 ppm

<0.0005%		 UV nm


<0.005% 		Max Abs.


Peroxides
Tetrahydrofuran
250 ppm BHT as stabilizer		  
Purity
Water
100 mL 		186562
99.9%
< 20 ppm
< 50 ppm 		   
 		    
Toluene  
Purity
Water
100 mL
Residue		 24,451-1
99.8%
< 10 ppm
< 50 ppm
<0.0005%		    
 		    

Visit the complete list of Sigma-Aldrich Anydrous Grade Solvents and Biotech Grade Solvents.

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Sigma-Aldrich offers a full range of high-purity solvents with extremely low water levels specifically manufactured for moisture sensitive Organic and Biotech applications.

    Anhydrous Solvents
    Biotech Solvents
    Sigma-Aldrich Anhydrous & Biotech Solvents Table

 

Anhydrous Solvents


Anhydrous Solvent Supplier Cross-Reference Guide   Use our anhydrous solvent supplier cross-reference guide to compare grades and packaging options with Sigma-Aldrich quality products. (180 Kb PDF)

Complete list of Anhydrous grade solvents


Sigma-Aldrich Anhydrous solvents are available in Sure/Seal Bottles and Pure-Pac containers.

Anhydrous 2-Methyltetrahydrofuran - A versatile alternative to Tetrahydrofuran and Dichloromethane

back to top

Biotech Solvents

Complete list of Biotech grade solvents

The Biotech line of solvents is characterized by not only low water content, but also minimal residue and clean UV spectra.

Purified for biotechnology applications such as:

Sigma-Aldrich Biotech solvents are available in Sure/Seal Bottles and Pure-Pac containers.

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Sigma-Aldrich Anhydrous & Biotech Solvents Table


  Anhydrous Biotech
  Acetonitrile Purity
Water
100 mL
Residue		 271004
99.8%
< 10 ppm
< 50 ppm
< 0.0005%		 494445
≥99.93%
< 10 ppm
 
<0.0002%		 UV nm
190
210
220
235-400
<0.008 meq/g
<0.0006 meq/g		 Max Abs.
1.000
0.030
0.010
0.005
Titr. Acid
Titr. Base
  Buytl acetate Purity
Water
Residue		 287725
≥99%
< 50 ppm
< 0.0005%		 496162
99.7%
< 10 ppm
<0.0005%		 UV nm


<0.0016 meq/g		 Max Abs.


Titr. Acid
  Carbon tetrachloride Purity
Water
100 mL
Residue		 289116
≥99.5%
< 20 ppm
<50 ppm
< 0.0003%		      
  1-Chlorobutane Purity
Water
100 mL
Residue		 414255
99.5%
< 30 ppm
< 50 ppm
< 0.0005%		 496170
≥99.5%
< 10 ppm

<0.0003%		 UV nm



<0.0016 meq/g		 Max Abs.



Titr. Acid
  Chloroform
  0.5-1.0% ethanol as stabilizer		 Purity
Water
100 mL
Residue		 401765
99.7%
< 10 ppm
< 50 ppm
< 0.0005%		 496189
≥99.9%
< 10 ppm

<0.0003%		    
  Dichloromethane
  50-150 ppm hydrocarbon as stabilizer		  Purity
Water
100 mL
Residue		 270997
99.0%
< 10 ppm
< 50 ppm
< 0.0005%		 494453
99.9%
< 20 ppm

<0.0003%		 UV nm
235
240
250
260
340-400		 Max Abs.
1.000
0.200
0.050
0.020
0.010
  N,N-Diisopropylethylamine Purity
Water
Residue		 271012
99.8%
< 50 ppm
< 0.0001%		 496219
99.5%
< 20 ppm 		   
  N,N-Dimethylformamide Purity
Water
Residue		 227056
99.8%
< 50 ppm
< 0.0005%		 494488
≥99.9%
< 50 ppm
<0.0005%		 UV nm
275
295
310
340-400
<0.0005 meq/g
<0.0003 meq/g		 Max Abs.
0.30
0.10
0.05
0.07
Titr. Acid
Titr. Base
  Dimethyl sulfoxide Purity
Water
Residue		 276855
≥99.9%
< 50 ppm
< 0.0005%		 494429
99.8%
< 50 ppm
<0.0005%		 UV nm
270
280
295
350-400		 Max Abs.
1.00
0.30
0.10
0.01
  1,4-Dioxane Purity
Water
100 mL
Residue		 296309
99.8%
< 30 ppm
< 50 ppm
< 0.0003%		      
  Ether
  1 ppm BHT as stabilzer		 Purity
Water
100 mL
Residue		 296082
≥ 99.7%
< 30 ppm
< 50 ppm
< 0.0003%		      
  Ethyl actate Purity
Water
Residue		 270989
99.8%
< 50 ppm
< 0.0005%		 494518
≥99.8%
< 10 ppm
<0.0003%		 UV nm
254
263
275-400
<0.0009 meq/g		 Max Abs.
1.00
0.05
0.01
Titr. Acid
  Heptane Purity
Water
100 mL
Residue		 246654
99%
< 10 ppm
< 50 ppm
< 0.0005%		 494526
≥99%
< 50 ppm

<0.0002%		 UV nm
197
210
220
230
260-400		 Max Abs.
1.00
0.40
0.15
0.05
0.01
  Methanol Purity
Water
100 mL
Residue		 322415
99.8%
< 20 ppm
< 50 ppm
< 0.0003%		 494437
99.93%
< 20 ppm

<0.0003%		 UV nm
203
220
230
240
260-400
<0.0003 meq/g
<0.0002 meq/g		 Max Abs.
1.00
0.60
0.15
0.05
0.01
Titr. Acid
Titr. Base
  3-Methyl-1-butanol  Purity
Water
100 mL
Residue		 309435
≥99%
< 30 ppm
< 50 ppm
< 0.0005%		 496200
≥99%
< 50 ppm

<0.0005%		 UV nm


<0.002 meq/g
<0.1%		 Max Abs.


Titr. Acid
Carbonyl
  1-Methyl-2-pyrrolidinone  Purity
Water 		328634
99.5%
< 50 ppm 		494496
≥99.5%
< 50 ppm 		UV nm
285
300
325
350-400
<0.01% meq/g 		Max Abs.
1.00
0.50
0.10
0.01
Free amines
  1-Propanol  Purity
Water
Residue		 279544
99.7%
< 50 ppm
< 0.0003%		 496197
99.7%

<0.0003%		 UV nm


<0.0004 meq/g 		Max Abs.


Titr. Acid
  Pyridine Purity
Water
100 mL
Residue		 270970
99.8%
< 30 ppm
< 50 ppm
< 0.0005%		 494410
≥99.9%
< 30 ppm

<0.0003%		 UV nm
<0.001%
<0.0005%
<0.002%
<0.0001% 		Max Abs.
Cl
Cu
NH3
SO4
  Tetrahydrofuran
  Inhibitor-free		 Purity
Water
100 mL
Residue		 401757
99.9%
< 20 ppm
< 50 ppm
< 0.0005%		 494461
≥99.9%
< 50 ppm

<0.0005%		 UV nm


<0.005% 		Max Abs.


Peroxides
  Tetrahydrofuran
  250 ppm BHT as stabilizer		 Purity
Water
100 mL 		186562
99.9%
< 20 ppm
< 50 ppm 		 
 		    
  Toluene Purity
Water
100 mL
Residue		 244511
99.8%
< 10 ppm
< 50 ppm
<0.0005%		  
 		    

Visit the complete list of Sigma-Aldrich Anydrous Grade Solvents and Biotech Grade Solvents

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