Return to Web Version
Sigma-Aldrich
Chemistry > Solvent Center > Learning Center > 2-Methyltetrahydrofuran
An alternative to Tetrahydrofuran and Dichloromethane

2-Methyltetrahydrofuran

2-Methyltetrahydrofuran (2-MeTHF) is a versatile, more environmentally friendly solvent derived from a variety of agricultural byproducts.

Features & Benefits

  • Quickly produces clean water phase splits (density of 0.86 g/mL at 25°C) without forming emulsions unlike THF or DCM
  • More easily dried than THF or DCM
  • Very stable even in highly acidic environments
  • Non-reactive, aprotic polar solvent
  • Forms an effective azeotrope with water
  • Higher boiling point (78-80°C)
      Lower solvent loss during reflux
      Allows rapid formation of Grignard reactants
  • Suitable replacement in most organometallic reactions where THF is used including Suzuki Coupling reactions

  Boiling Point Density g/mL
at 25°C
Flash Point Viscosity
at 25°C
Dielectric Constant
at 25°C
2-Methyltetrahydrofuran 78-80°C 0.860 -12.0 0.600 6.97
Tetrahydrofuran 65-67°C 0.889 -17.2 0.456 7.52
Dichloromethane 39.8-40°C 1.325 none 0.413 8.93

2-Methyltetrahydrofuran

 

Products
Product #  Product Name Add to Cart
414247 anhydrous, ≥99.0%, contains 250ppm BHT as stabilizer
   
673277 anhydrous, ≥99%, Inhibitor-free
   
155810 ReagentPlus®, ≥98.5%, contains 150-400ppm BHT as stabilizer
   
your favorite gene search

powered by ingenuity

Service & Support
Ordering
Corporate

©2011 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA, SAFC, SIGMA-ALDRICH, ALDRICH, and SUPELCO are trademarks of Sigma-Aldrich Co. LLC, registered in the US and other countries. FLUKA is a trademark of Sigma-Aldrich GmbH, registered in the US and other countries. Sigma brand products are sold through Sigma-Aldrich, Inc. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Site Use Terms | Privacy

  • YouTube
  • Twitter
  • LinkedIN
  • Facebook