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Designer Surfactants

Designer surfactants have been developed to make Green Chemistry readily available to synthetic chemists through micellar catalysis, allowing common reactions to be run in water instead of organic solvent. This technology is enabled by the water-promoted aggregation of amphiphiles into nanomicelles, which surround water-insoluble organic substrates and provide a facile environment for reactions. Now that many of the most synthetically useful transformations can be performed in aqueous conditions, the scientific community can better contribute to Green Chemistry efforts and the reduction of organic solvent waste. In collaboration with the Lipshutz Research Group, Aldrich Chemistry is proud to offer designer surfactants for myriad organic reactions.




Designer Surfactants

Amphiphiles particularly developed to assist transition metal-catalyzed cross-coupling reactions at room temperature and in water

  • PTS Vitamin E core linked to PEG arm through sebacate; forms micelles in the shapes of both rods and spheres
  • TPGS-750-M PTS derivative with shorter, succinic acid linker and longer PEG for greater lipophilic-hydrophilic balance; generates spherical particles
  • Nok Phytosterol core that is PEGylated through a succinic acid linker; forms worm-like micelles




All-in-One Kits Complete with TPGS-750-M

Aldrich Chemistry and the Lipshutz Research Group have developed the next generation of kits containing the designer surfactant TPGS-750-M. These all-in-one boxed reactions enable transition metal-catalyzed cross-coupling reactions to be run at room temperature. These single-use kits facilitate simple setup of commonly used reactions and come with premeasured catalysts, surfactant, and additives, as well as written protocols for guidance.

Find out more about these kits and their protocols in our Technology Spotlight: Second-Generation, Designer-Surfactant Kits: Aqueous Reactions in a Box

Established Designer Surfactants

Product #

Image

Description

Molecular Formula

Add to Cart

698717 Polyoxyethanyl-α-tocopheryl sebacate 15 wt. % in H2O  
776033 SPGS-550-M 2% w/w in H2O Green Alternative C58H104O16
763896 DL-α-Tocopherol methoxypolyethylene glycol succinate Green Alternative  
733857 DL-α-Tocopherol methoxypolyethylene glycol succinate solution 2 wt. % in H2O Green Alternative  
763918 DL-α-Tocopherol methoxypolyethylene glycol succinate solution 5 wt. % in H2O Green Alternative  

2nd Generation Designer Surfactant Kits

Product #

Image

Description

Molecular Formula

Add to Cart

802387 Amide Coupling in a Box Green Alternative  
802298 Buchwald-Hartwig Amination in a Box Green Alternative  
802328 Heck Coupling  
802352 Miyaura Borylation in a Box Green Alternative  
802344 Negishi Coupling in a Box Green Alternative  
802360 Olefin Metathesis in a Box Green Alternative  
802301 Sonogashira Coupling in a Box Green Alternative  
802336 Stille Coupling in a Box Green Alternative  
802271 Suzuki-Miyaura Coupling in a Box Green Alternative  
802379 Trifluoromethylation in a Box Green Alternative  

1st Generation Designer Surfactant Kits

Product #

Image

Description

Molecular Formula

Add to Cart

747599 Boxed reaction: Buchwald-Hartwig in Lipshutz Surfactant Green Alternative  
747904 Boxed reaction: Heck Reaction in Lipshutz Surfactant Green Alternative  
747912 Boxed reaction: Sonogashira Reaction in Lipshutz Surfactant Green Alternative  
747602 Boxed reaction: Suzuki coupling in Lipshutz Surfactant Green Alternative