Stable Isotopes

Stable Isotopes in Metabolomics and Proteomics



 Metabolomics

Stable Isotope labeled compounds enable specific qualitative and quantitative study of a metabolome. A stable isotope-resolved metabolomics (SIRM) approach helps investigators identify and quantify specific metabolites found in complex matrices, using NMR and mass spectrometry as analytical tools. Both tracer and flux studies benefit from stable isotope label assistance. Metabolic pathways can be studied by tracking naturally occurring and disease-indicated metabolites. Additionally, the effects of exogeneous substances or perturbations on the metabolome can be better elucidated with the use of stable isotope labeled internal standards coupled with mass spec determination.

We offer a variety of deuterated, 13C, and 15N-labeled compounds, such as carbohydrates, amino acids, vitamins, steroids, and other biologically active compounds for this application. ISOTEC Stable Isotopes has the most diverse line of labeled bioactive compounds.

 Proteomics

Quantitative proteomics using Mass Spectrometry has developed into a valuable technology for discovering the structure and function of proteins. We offer stable isotope labeled products for metabolic labeling, enzymatic labeling, chemical labeling and stable isotope labeling with amino acids in cell culture (SILAC). We also offer the widest variety of protected amino acids for peptide synthesis.