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Stable Isotopes

Publications

Electrolytic IVER-MS Technology for the Isotopic Quantitation of Select Electroactive Materials
Technical journal article: J. Kuo, M. Gray, C.T. Tan, L. Chandler, and M. May
Journal of the Electrochemical Society, volume 155, f43-f48 (2008)

Comparison of Isotopic Enrichment calculations for CO using Mass Spectrometry data
Scientific poster: J. Kuo, M. May, M. Gray, I. Knyazhansky, C.T. Tan, and S. Pedersen
Pittcon 2008, abstract 2770-4p, New Orleans, Louisiana, 6-March 2008

Electrochemical and Isotopic investigation of oxalic acid
Scientific poster: M. May, J. Kuo, E. Paul, V. Katovic, and C.T. Tan
Pittcon 2009, abstract 250-13p, Chicago, Illinois, 8-March 2009

Consolidated Vacuum Sublimation Module
 Patent Application: M. May
USPTO application 2008/0299023a1, published 04-December 2008

Process and Apparatus for Isotope determination of Condensed Phase Samples
Patent Application (continuation in part): M. May and M. Gray
USPTO application 2008/0035840a1, published 14-February 2008

Jet Expansion Module for Liquid-Sampled GC-Discharge Ionization Detection of Liquefied Gases (64 K PDF)
Michael May, Todd Poeppelmeier and John Kuo
Quality Control Lab, Isotec Division, Sigma-Aldrich, Miamisburg, Ohio 45342
Analytical Chemistry 2003, 75, 1221-1224

 

Spark Combustion Reactor for 13-Carbon Isotope Enrichment Analysis of Gases (200 K PDF)
Michael May, Michael Gray, John Kuo and C.T. Tan
Quality Control Laboratory, Isotec Division, Sigma–Aldrich, Miamisburg, Ohio 45342
Review of Scientific Instruments, Volume 74, Number 4, April 2003

 

Vacuum-assisted Quartz Combustion Reactor for 13C-Isotope Analysis of Highly-enriched Protein (60 K PDF)
Michael May, John Kuo and C.T. Tan
Quality Control Laboratory, Isotec Division, Sigma–Aldrich, Miamisburg, Ohio 45342
Pittcon 2004, Chicago, Illinois, March 7, 2004

 

Mass Distribution Calculation for Isotopically Enriched Macromolecules (296 K PDF)
John Kuo, Michael Gray, Michael May and C.T. Tan
Quality Control Laboratory, Isotec Division, Sigma–Aldrich, Miamisburg, Ohio 45342
Pittcon 2003, New Orlando, Florida, March 12, 2003

 

Jet Apparatus for Liquid Sampled GC of Condensable Gases (34 K PDF)
Michael May, Todd Poeppelmeier and John Kuo
Quality Control Laboratory, Isotec Division, Sigma–Aldrich, Miamisburg, Ohio 45342
Pittcon 2002, New Orleans, Louisiana, March 17, 2002

 

MS Analysis of Isotopically Enriched Gases Using Simplex (29 K PDF)
John Kuo, Michael Gray
Quality Control Laboratory, Isotec Division, Sigma–Aldrich, Miamisburg, Ohio 45342
Pittcon 2002, New Orleans, Louisiana, March 17, 2002

 

Vacuum Electrolysis Reactor Technique for Quantitation of 13-Carbon Isotope Enrichment at the C1-Position of Formic Acid and Acetic Acid (178 K PDF)
Michael May, John Kuo and C.T. Tan
Quality Control Laboratory, Isotec Division, Sigma–Aldrich, Miamisburg, Ohio 45342
Analytical Chemistry, Vol 76, No. 18, September 15, 2004

 

Applications of Quantitative D-NMR in Analysis of Deuterium Enriched Compounds (210 K PDF)
David H. Schory, John Kuo and C.T. Tan
Quality Control Laboratory, Isotec Division, Sigma–Aldrich, Miamisburg, Ohio 45342
Pittcon 2004, Chicago, Illinois, March 7, 2004

 

Ile, Leu, and Val Methyl Assignments of the 723-Residue Malate Synthase G Using a New Labeling Strategy and Novel NMR Methods
Vitali Tugarinov and Lewis E. Kay
J. Am. Chem. Soc. 2003, 125 13868-78.


  Biomolecular NMR

Nuclear Magnetic Resonance Spectroscopy of High-Molecular-Weight Proteins (2.19 MB PDF)
Vitali Tugarinov, Peter M. Hwang, Lewis E. Kay
Annu. Rev. Biochem. 2004, 73, 107-146.



  Nutrition/Metabolism

Metabolic profiling of cell growth and death in cancer: applications in drug discovery (193 K PDF)
László G. Boros, Marta Cascante and Wai-Nang Paul Lee
Drug Discovery Today, Vol. 7, No. 6, 2002. 364-372.


Metabolic Biomarker and Kinase Drug Target Discovery in Cancer Using Stable Isotope-Based Dynamic Metabolic Profiling (SIDMAP) (111 K PDF)
László G. Boros, Daniel J. Brackett and George G. Harrigan
Current Cancer Drug Targets, 2003, 3, 447-455.


Use of metabolic pathway flux information in targeted cancer drug design (480 K PDF)
László G. Boros, Natalie J. Serkova, Marta S. Cascante and Wai-Nang Paul Lee
Drug Discovery Today, Vol. 1, No. 4, 2004. 435-443.

Medical Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics (193 K PDF)
George G. Harrigan, Daniel J. Brackett and László G. Boros
Medical Chemistry, 2005, 5, 13-20

Emerging applications of kinetic biomarkers in preclinical and clinical drug development (983 K PDF)
Scott M. Turner and Marc Hellerstein
Drug Discovery and Development, 2005, 8, 115-126