Nucleotides

Stable Isotope Labeled Nucleic Acids for Biomolecular NMR

Advancements in NMR methodology, increased availability of larger, more powerful NMR instrumentation and the availability of stable isotope labeled nucleic acids have made the structure and function elucidation of nucleotide macromolecules a genuine reality. The use of labeled nucleic acids helps to overcome challenges such as extensive spectral crowding, increased resonance linewidths, and overall NMR signal degeneracy by providing the ability to enhance experimental sensitivity and spectral resolution. These enhancements help to increase the accuracy of solution structure determinations by facilitating the measurements of local and long-range distance restraints. 13C and/or 15N labeled nucleic acids have been employed to study the links between RNA secondary structure and global conformation as well as determine dynamics in DNA flexibility.

ISOTEC Stable Isotopes offers an extensive array of 13C, 15N, and D labeled nucleic acids. Our NTPs and NMPs are supplied as sodium salt powders or are suspended in 5 mM Tris HCl buffer.

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Products for Nucleic Acid Research

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Deoxyribonucleotide monophosphates

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900386 2′-Deoxyadenosine-13C10,15N5 5′-monophoshate sodium salt solution ≥98 atom %, ≥95% (CP), 100 mM in 5 mM Tris HCl
648620 2′-Deoxyadenosine-13C10,15N5-monophosphate sodium salt 98 atom % 15N, 98 atom % 13C, 90% (CP)
648612 2′-Deoxycytidine-13C9,15N3 5′-monophosphate sodium salt 98 atom % 13C, 98 atom % 15N, 90% (CP)
900383 2′-Deoxycytidine-13C9,15N3 5′-monophosphate sodium salt solution ≥98 atom %, ≥95% (CP), 100 mM in 5 mM Tris HCl
648604 2′-Deoxyguanosine-13C10,15N5 5′-monophosphate sodium salt 98 atom % 15N, 98 atom % 13C, 90% (CP)
900384 2′-Deoxyguanosine-13C10,15N5 5′-monophosphate sodium salt solution ≥98 atom %, ≥95% (CP), 50 mM in 5 mM Tris HCl
648590 Thymidine-13C10, 15N2 5′-monophosphate sodium salt 98% 13C, 98 atom % 15N, 90% (CP)
900385 Thymidine-13C10,15N2 5′-monophosphate sodium salt solution ≥98 atom %, ≥95% (CP), 100 mM in 5 mM Tris HCl

Deoxyribonucleotide triphosphates

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646237 2′-Deoxyadenosine-13C10,15N5 5′-triphosphate sodium salt solution 98 atom % 15N, 98 atom % 13C, 90% (CP), 100 mM in 5 mM Tris HCl
646229 2′-Deoxycytidine-13C9,15N3 5′-triphosphate sodium salt solution 98 atom % 13C, 98 atom % 15N, 90% (CP), 100 mM in 5 mM Tris HCl
646210 2′-Deoxyguanosine-13C10,15N5 5′-triphosphate sodium salt solution ≥98 atom % 13C, ≥98 atom % 15N, ≥90% (CP), 100 mM in 5 mM Tris HCl
646202 Thymidine-13C10,15N2 5′-triphosphate sodium salt solution 98 atom % 13C, 98 atom % 15N, 90% (CP), 100 mM in 5 mM Tris HCl

Ribonucleotide monophosphates

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662658 Adenosine-15N5 5′-monophosphate sodium salt 98 atom % 15N, 90% (CP)
650676 Adenosine-13C10,15N5 5′-monophosphate sodium salt solution 98 atom % 15N, 98 atom % 13C, 90% (CP), 100 mM in 5 mM Tris HCl
900382 Adenosine-15N5 5′-monophosphate sodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM in 5 mM Tris HCl
662682 Cytidine-15N3 5′-monophosphate sodium salt 98 atom % 15N, 90% (CP)
900379 Cytidine-15N3 5′-monophosphate sodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM in 5 mM Tris HCl
650692 Cytidine-13C9,15N3 5′-monophosphate sodium salt solution ≥98 atom %, 95% (CP), 100 mM in 5 mM Tris HCl
662674 Guanosine-15N5 5′-monophosphate sodium salt 98 atom % 15N, 90% (CP)
900380 Guanosine-15N5 5′-monophosphate sodium salt solution ≥98 atom % 15N, ≥95% (CP), 50 mM in 5 mM Tris HCl
760161 Guanosine-13C10,15N5 3′,5′-cyclic monophosphate calcium salt 99 atom % 13C, 98 atom % 15N, 95% (CP)
650684 Guanosine-13C10,15N5 5′-monophosphate sodium salt solution ≥98 atom %, ≥95% (CP), 50 mM in 5 mM Tris HCl
662666 Uridine-15N2 5′-monophosphate sodium salt 98 atom % 15N, 90% (CP)
900381 Uridine-15N2 5′-monophosphate sodium salt solution ≥98 atom % 15N, ≥95% (CP), 100 mM in 5 mM Tris HCl
651370 Uridine-13C9,15N2 5′-monophosphate sodium salt solution ≥98 atom %, ≥95% (CP), 100 mM in 5 mM Tris HCl

Ribonucleotide triphosphates

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738034 Adenosine-2,8-d2,1′,2′,3′,4′,5′,5′-d6 5′-triphosphate sodium salt solution 98 atom % D, 95% (CP), 100 mM in 5 mM Tris HCl
707783 Adenosine-15N5 5′-triphosphate sodium salt solution 98 atom % 15N, 95% (CP), 100 mM in 5 mM Tris HCl
710695 Adenosine-13C10 5′-triphosphate sodium salt solution 98 atom % 13C, 90% (CP, HPLC), 100 mM in 5 mM Tris HCl
645702 Adenosine-13C10,15N5 5′-triphosphate sodium salt solution 98 atom % 13C, 98 atom % 15N, 90% (CP), 100 mM in 5 mM Tris HCl
707759 Cytidine-15N3 5′-triphosphate sodium salt solution 98 atom % 15N, 95% (CP), 100 mM in 5 mM Tris HCl
738042 Cytidine-5,6-d2,1′,2′,3′,4′,5′,5′-d6 5′-triphosphate sodium salt solution 98 atom % D, 95% (CP), 100 mM in 5 mM Tris HCl
645699 Cytidine-13C9,15N3 5′-triphosphate sodium salt solution 98 atom % 13C, 98 atom % 15N, 90% (CP), 100 mM in 5 mM Tris HCl
711020 Cytidine-13C9 5′-triphosphate sodium salt solution 98 atom % 13C, 95% (CP), 100 mM in 5 mM Tris HCl
707775 Guanosine-15N5 5′-triphosphate sodium salt solution 98 atom % 15N, 95% (CP), 100 mM in 5 mM Tris HCl
738069 Guanosine-8-d,1′,2′,3′,4′,5′,5′-d6 5′-triphosphate sodium salt solution 98 atom % D, 95% (CP), 100 mM in 5 mM Tris HCl
710687 Guanosine-13C10 5′-triphosphate sodium salt solution 98 atom % 13C, 95% (CP), 100 mM in 5 mM Tris HCl
645680 Guanosine-13C10,15N5 5′-triphosphate sodium salt solution ≥98 atom %, ≥95% (CP), 100 mM in 5 mM Tris HCl
707767 Uridine-15N2 5′-triphosphate sodium salt solution 98 atom % 15N, 95% (CP), 100 mM in 5 mM Tris HCl
738050 Uridine-5,6-d2,1′,2′,3′,4′,5′,5′-d6 5′-triphosphate sodium salt solution 98 atom % D, 95% (CP), 100 mM in 5 mM Tris HCl
711012 Uridine-13C9 5′-triphosphate sodium salt solution 98 atom % 13C, 95% (CP), 100 mM in 5 mM Tris HCl
645672 Uridine-13C9,15N2 5′-triphosphate sodium salt solution 98 atom % 15N, 98 atom % 13C, 90% (CP), 100 mM in 5 mM Tris HCl