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Alpha Ketoacids

Stable Isotope Labeled Alpha Ketoacids for Biomolecular NMR

The use of labeled α-Ketoacids has been invaluable for enabling the solution NMR studies of progressively larger proteins and supra-molecular systems. These products allow for enhanced sensitivity and resolution by incorporating selective 13C and/or deueterium labels into the methyl groups of the highly abundant residues of Leucine, Valine and Isoleucine. While initial applications have centered on solution NMR, there remains potential to exploit these labeling patterns to explore more challenging proteins and protein-complexes by solid-state NMR.

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Literature
α-Ketoacids as Biosynthetic Precursors for Protein NMR

Stable Isotope Home Page

Product #

Structure

Description

Isotopic Purity

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805777 2-Ketobutyric-1-13C acid ≥99 atom % 13C
717150 2-Ketobutyric acid-3,3-d2 sodium salt hydrate 97 atom % D
571342 2-Ketobutyric acid-4-13C sodium salt hydrate 99 atom % 13C
607541 2-Ketobutyric acid-13C4,3,3-d2 sodium salt hydrate 98 atom % D
99 atom % 13C
589276 2-Ketobutyric acid-4-13C,3,3-d2 sodium salt hydrate 98 atom % D
99 atom % 13C
607533 2-Ketobutyric acid-4-13C,3,3,4,4,4-d5 sodium salt hydrate 48-70 atom % D (13CD3)
97 atom % D (CD2)
99 atom % 13C
637831 2-Ketobutyric acid-4-13C,4-d sodium salt hydrate 97 atom % D
99 atom % 13C
634727 2-Ketobutyric acid-4-13C,4,4-d2 sodium salt hydrate 98 atom % D
99 atom % 13C
704334 2-Ketoglutaric acid-1-13C 99 atom % 13C
795917 2-Keto-3-(methyl-13C,d1)-butyric-3,4,4,4-d4 acid sodium salt 98 atom % D
99 atom % 13C
634379 2-Keto-3-(methyl-13C,d2)-butyric acid-4-13C,d2 sodium salt 98 atom % 13C
98 atom % D
717169 2-Keto-3-methylbutyric acid-3-d sodium salt hydrate 98 atom % D
596418 2-Keto-3-(methyl-d3)-butyric acid-1,2,3,4-13C4 sodium salt 98 atom % D
99 atom % 13C
637858 2-Keto-3-(methyl-d3)-butyric acid-1,2,3,4-13C4, 3-d sodium salt 98 atom % D
99 atom % 13C
594903 2-Keto-3-(methyl-d3)-butyric acid-4-13C sodium salt 98 atom % D
99 atom % 13C
691887 2-Keto-3-(methyl-d3)-butyric acid-4-13C,3-d sodium salt 97 atom % D
99 atom % 13C
571334 2-Keto-3-(methyl-13C)-butyric-4-13C acid sodium salt 99 atom % 13C
589063 2-Keto-(3-methyl-13C)-butyric-4-13C,3-d acid sodium salt 98 atom % D
99 atom % 13C
663980 2-Keto-3-methylbutyric acid-13C5 sodium salt 99 atom % 13C
607568 2-Keto-3-methylbutyric acid-13C5,3-d sodium salt 98 atom % D
99 atom % 13C
487716 2-Keto-4-methylpentanoic-1-13C acid sodium salt 99 atom % 13C
616621 2-Keto-4-methyl-d3-pentanoic acid sodium salt 98 atom % D
797235 2-oxo-4,4,4-trifluorobutyric acid sodium salt