Stable Isotope Labeled Alpha Ketoacids for Biomolecular NMR
The use of labeled α-Ketoacids has been invaluable for enabling the solution NMR studies of progressively larger proteins and supra-molecular systems. These products allow for enhanced sensitivity and resolution by incorporating selective 13C and/or deueterium labels into the methyl groups of the highly abundant residues of Leucine, Valine and Isoleucine. While initial applications have centered on solution NMR, there remains potential to exploit these labeling patterns to explore more challenging proteins and protein-complexes by solid-state NMR.
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