Chemical Tagging

Stable Isotope Products for Chemical Labeling

Stable isotope coded chemical tags enable researchers to perform mass spectrometric- based proteomics studies in the absence of metabolic labeling. Labeling occurs by site-specific incorporation of stable isotope labeled tags at cysteine residues or the general labeling of amines and carboxyl groups in protein samples. These techniques are particularly useful for applications where metabolic labeling is impractical or undesirable such as clinical samples. Many methods for the chemical derivatization of proteins exist (1-3), offering researchers the ability to optimize stable isotope label incorporation based on target proteins. In addition to stable isotope labeled tags, the development of innovative matrixes and improvements in instrumentation greatly impact stable isotope usage in quantitative proteomics (4-5). ISOTEC has the high-quality isotopically enriched products needed for mass-spectrometry based quantitative proteomics. Consult with our R&D scientists to develop novel stable isotope labeled compounds for use in comparative proteomic applications.

References
1. Ong, S.E. and Mann, M. (2005) Mass spectrometry-based proteomincs turns quantitative. Nature Chemical Biology, 1, 252-262.
2. Julka, S. and Regnier, F. (2004) Quantification in Proteomics through Stable Isotope Coding: A Review. Journal of Proteome Research, 3, 350-363.
3. Julka, S. and Regnier, F. (2005) Recent Advancements in differential proteomics based on stable isotope coding. Briefings in Functional Genomics and Proteomics, 4(2), 158-177.
4. Matsuo, E., Toda, C., Watanobe, M., Ojima, N., Izumi, S., Tanaka, K., Tsunasawa, S., Nishimura, O. (2006) Selective detection of 2-nitrobenzenesulfenyl-labeled
peptides by matrix-assisted laser desorption/ionization-time of flight mass spectrometry using a novel matrix. Proteomics, 6, 2042-9.
5. Fenselau, C. (2007) A review of quantitative methods for proteomic studies. Journal of Chromatography B, 855, 14-20.

Stable Isotope Home Page

Product #

Description

Add to Cart

531227 Acetaldehyde-13C2 99 atom % 13C
176567 Acetaldehyde-d4 ≥99 atom % D, ≥98% (CP)
607452 Acetic anhydride-1,1′-13C2,d6 99 atom % 13C, 98 atom % D
487821 Acetic anhydride-13C4 99 atom % 13C
607428 Acetic anhydride-13C4,d6 97 atom % D, 99 atom % 13C
175641 Acetic anhydride-d6 99 atom % D
633259 N-Acetoxy-d3-succinimide 98 atom % D
607517 Acetyl chloride-1-13C,d3 99 atom % 13C, 98 atom % D
175668 Acetyl chloride-d3 99 atom % D
577820 Acrylamide-1-13C 99 atom % 13C
636568 Acrylamide-2,3,3-d3 98 atom % D, 98% (CP)
586617 Acrylamide-13C3 99 atom % 13C, 98% (CP)
798924 Acrylamide-13C3,2,3,3-d3 99 atom % 13C, 98 atom % D, 98% (CP)
485497 Aniline-13C6 99 atom % 13C
485691 Benzoic acid-(phenyl-13C6) 99 atom % 13C
366048 Benzoyl chloride-d5 99 atom % D
279323 Benzoyl chloride-α-13C 99 atom % 13C
283835 Bromoacetic acid-13C2 99 atom % 13C
488232 Bromobenzene-13C6 99 atom % 13C
485209 2-Bromoethanol-1,1,2,2-d4 98 atom % D
600024 2-Bromoethanol-13C2,1,1,2,2-d4 98 atom % D, 99 atom % 13C, 97% (CP)
614491 3-Bromo-1-propan-d6-ol 98 atom % D
604089 Chloroacetyl chloride-13C2 99 atom % 13C, 99% (CP)
491535 4-Chlorobenzaldehyde-2,3,5,6-d4 98 atom % D, 99% (CP)
488534 Chlorobenzene-13C6 99 atom % 13C
366560 1,4-Dibromobenzene-d4 98 atom % D
486558 Dimethyl-d6-amine 99 atom % D
485500 Dimethyl sulfate-13C2 99 atom % 13C
590096 Dimethyl sulfate-13C2,d6 99 atom % 13C, 98 atom % D
164526 Dimethyl sulfate-d6 99 atom % D
613614 Ethane-d5-thiol 98 atom % D
457833 Ethylene-d4 oxide ≥98 atom % D, ≥99% (CP), contains hydroquinone as stabilizer
489417 Formaldehyde-13C solution 20 wt. % in H2O, 99 atom % 13C
492620 Formaldehyde-d2 solution ~20 wt. % in D2O, 98 atom % D
596388 Formaldehyde-13C, d2 solution 20 wt. % in D2O, 98 atom % D, 99 atom % 13C
454524 Glycerol-1,1,2,3,3-d5 98 atom % D
607312 Guanidine-13C,15N3 hydrochloride 99 atom % 13C, 98 atom % 15N
592668 Iodoacetamide-15N 98 atom % 15N
595489 Iodoacetic acid-13C2 99 atom % 13C
277185 Iodomethane-13C 99 atom % 13C, 99% (CP), contains copper as stabilizer
294756 Iodomethane-13C,d3 99.5 atom % D, 99 atom % 13C, 99% (CP), contains copper as stabilizer
277630 Methylamine-13C hydrochloride 99 atom % 13C
607118 Methylamine-13C,15N 98 atom % 15N, 99 atom % 13C
608467 O-Methylisourea-13C,15N2 hydrochloride 98 atom % 15N, 99 atom % 13C
493171 O-Methylisourea-13C hydrochloride 99 atom % 13C
486086 Nicotinic acid-(ring-d4) ≥98 atom % D, ≥98% (CP)
640492 2-Nitrobenzenesulfenyl chloride-13C6 99 atom % 13C, 98% (CP)
490504 Phenol-13C6 99 atom % 13C
493244 Phenyl-d5 isocyanate 98 atom % D
603597 Phenyl-13C6 isocyanate 99 atom % 13C
615692 Propionic anhydride-d10 ≥98 atom % D, ≥99% (CP)
455695 Propylene oxide-d6 ≥98 atom % D, ≥99% (CP), contains hydroquinone as stabilizer
279293 Sodium acetate-1-13C 99 atom % 13C
282014 Sodium acetate-13C2 99 atom % 13C
279315 Sodium acetate-2-13C 99 atom % 13C
176079 Sodium acetate-d3 99 atom % D
632341 Suberic acid-2,2,7,7-d4 bis (3-sulfo-N-hydroxysuccinimide ester) disodium salt 98 atom % D, 97% (CP)
603902 Succinic anhydride-1,4-13C2 ≥99 atom % 13C, ≥99% (CP)
293741 Succinic anhydride-2,2,3,3-d4 98 atom % D
578517 Succinic anhydride-13C4 99 atom % 13C