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Fluorous Chemistry

Proteomics and Metabolomics

The seminal publication in this field was published by Peters et al from the Genomics Institute of the Novartis Research Foundation in 2005 and describes the use of fluorous bioreagents in proteomics. Within that publication, they described fluorous reagents for Cys tagging, fluorous thiols for phosphoproteome analysis, and fluorous NHS esters for amine tagging. Since that publication, the line of bioreagents has been extended to include products for carbonyl tagging and click chemistry.

Recommended Literature
Brittain, S. M.; Ficarro, S. B.; Brock, A.; Peters, E. C. Enrichment and Analysis of Peptide Subsets using Fluorous Affinity Tags and Mass Spectrometry. Nat. Biotechnol. 2005, 23, 463.

Fluorous maleimide


FTI Products: BR013173 (19425), BR107173 (40889)

Fluorous maleimide Structure Image

Fluorous maleimide is used for the tagging and enrichment of cysteinyl peptides.

Fluorous iodoacetamide


FTI Products: BR013174 (51526), BR107174 (55266)

Fluorous iodoacetamide Structure Image

Fluorous iodoacetamide is used for the tagging and enrichment of cysteinyl peptides.

Fluorous NHS ester


FTI Products: BR013175 (41687), BR107175 (73028)

Fluorous NHS ester Image

Fluorous NHS ester is used for the tagging of free amines such as peptide N-termini and lysines.

Fluorous azide


FTI Products: BR017190 (97087)

Fluorous NHS ester Image

Fluorous azide is used to conduct click chemistry in the tagging of alkyne modified biomolecules.

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