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Fluorous Chemistry

Separation Media


The separation of fluorous compounds from non-fluorous compounds using fluorous silica gel is the central theme of fluorous techniques. Fluorous solid phase extraction (F-SPE) is used for quick separations of reaction mixtures involving FluoroFlash® tags, scavengers, and reagents. The separation of fluorous compounds by F-SPE is a reliable and generic procedure that more greatly resembles filtration than chromatography. The facile separation depends primarily on the presence or absence of a light fluorous tag, not polarity or other molecular features that control traditional chromatography.


Fluorous Solid Phase Extraction Dye Demonstration Image
Fluorous Solid Phase Extraction Dye Demonstration

A visual representation of the FluoroFlash® solid phase extraction technique illustrates the easy separation of a fluorous-tagged product from the non-fluorous compounds through the use of colored dyes.

A mixture of a non-fluorous dye and a fluorous dye is loaded onto the F-SPE cartridge.

Non-fluorous dye is washed off with a fluorophobic solvent wash, 80:20 MeOH:water (middle test tube).

Fluorous dye is washed off with a fluorophilic solvent wash, MeOH (right test tube).

For detailed F-SPE Application Notes, please visit our Learning Center.


Fluorous Solid Phase Extractions are marked by:

  • High selectivity
  • Simple binary separation
  • Large loading capacity
  • No fluorous solvents used
  • Recyclable up to 10 times
  • Automation compatible

 


Description Size Product #
FluoroFlash® SPE cartridges, 2 g, 8 cc tube Pack of 20 14196
FluoroFlash® SPE cartridges, 5 g, 10 cc tube Pack of 10 00866
FluoroFlash® SPE cartridges, 10 g, 60 cc tube Pack of 5 08967
FluoroFlash® SPE cartridges, 20 g, 60 cc tube Pack of 2 08966
FluoroFlash® SPE cartridges, 20 g, 60 cc tube Pack of 5 06961
FluoroFlash® Silica Gel, 40 micron particle size 100 g 08965
FluoroFlash® TLC Plates with F254 indicator Pack of 10 16888