Chemical Synthesis

Rieke Organozinc Solutions

Organozinc reagents react with a variety of electrophiles and have been employed in numerous organic transformations such as cross-coupling reactions,1 conjugate additions,2 and electrophilic amination reactions.3 Much of their utility stems from their compatibility with a broad spectrum of functional groups. Interestingly, the choice of a preparative route to organozinc products does play an important role in their subsequent reactivity and stability. Sigma-Aldrich offers a comprehensive line of Rieke® Organozincs that are stable as solutions in tetrahydrofuran. The list below contains our latest additions to this line of useful reagents. If you do not see the reagent you need, “please bother us” at mredlich@sial.com.



Click here to view our organozincs Chemfile. Vol. 2 No. 5



Product Name Product # 
4-(Ethoxycarbonyl)phenylzinc bromide, 0.5M solution in tetrahydrofuran 520284
5-Ethoxycarbonyl-2-thienylzinc bromide,0.5M solution in tetrahydrofuran  533548
4-Iodobenzylzinc bromide, 0.5M solution in tetrahydrofuran 533289
3-Iodobenzylzinc bromide, 0.5M solution in tetrahydrofuran 533297
2-Iodobenzylzinc bromide 0.5M in tetrahydrofuran 635650
2-Acetoxyphenyl zinc iodide, 0.5M solution in tetrahydrofuran  630357
4-Acetoxyphenyl zinc iodide, 0.5M solution in tetrahydrofuran  630365
3-Acetoxyphenyl zinc iodide, 0.5M solution in tetrahydrofuran 630373
5-Acetoxypentyl zinc bromide, 0.5M solution in tetrahydrofuran 630381
4-Acetoxybutyl zinc bromide, 0.5M solution in tetrahydrofuran 630403
2-Biphenylzinc iodide, 0.5M solution in tetrahydrofuran 630411
5-Ethoxycarbonyl-2-furylzinc bromide, 0.5M solution in tetrahydrofuran 641812

References:
(1) (a)Akritopoulou-Zanze, l. et al. Bioorg. Med. Chem. Lett. 2004, 14, 2079. (b) Fillon, H. et al. Tetrahedron 2003, 59, 8199.
(2)  Gomes, P. et al. Synlett 2002, 1673.
(3)  Velarde-Ortiz, R. et al. Tetrahedron Lett. 1998, 39, 9157