Solvent Center

Aldrich® Sure/Seal™

The New Aldrich® Sure/Seal System

As the leader in air-sensitive chemistry, Sigma-Aldrich carries by far the largest breadth of anhydrous solvents and air-sensitive reagents to service the research market. In the late 1970’s, the Aldrich Sure/ Seal bottle was developed to protect our growing line of air-sensitive reagents from oxygen and moisture. The Aldrich Sure/Seal not only maintains product integrity, but also facilitates the use of these products. While the crimp cap ensures an air-tight seal, the liner provides greater resealing qualities to further improves the Aldrich Sure/Seal system.


New Crimp Cap Design

  • Increased puncture area by 4x to accommodate multiple punctures
  • Crimp cap helps maintain product quality by providing an air-tight system

New Aldrich
Sure/Seal style

Past style

New Plug Style

  • Maximimizes surface area contact with the bottle to prevent moisture and oxygen entry
  • More than 50% thicker than competing brands
 

New Elastomer Composition

  • Provides outstanding resealing properties
  • Secondary resin layer ensures resistance to chemicals
  • Outperforms competing seals with respect to moisture uptake 
   
 

Aldrich Sure/Seal Testing Results
To illustrate the effectiveness of our new Sure/Seal system, we evaluated it against another supplier (Competitor A) to see how each performed when tested for Oxygen Transmission (OTR), Moisture uptake and Liner Integrity after repetitive puncturing.


Unpunctured

4 Punctures

 

New Aldrich Sure/Seal Brochure
New Sure/Seal Brochure

Oxygen Transmission Rate Testing
A measurement of the amount of O2 allowed to permeate into the bottle over a period of time. This test demonstrates the cap and liners ability to maintain an air-tight seal.



Oxygen Transmission Rate Comparison

Overcaps were torqued to 40 lbs per square and liners were punctured four times with an 18g needle.

OTR testing demonstrates the New Sigma-Aldrich Sure/Seal system is better suited to sustain product quality than that of “Competitor A”.

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Moisture Analysis
 
Testing Results (KF)

Karl Fischer utilizes a coulometric titration method to measure the rate of moisture uptake. To determine the effectiveness of the liner’s seals and closure designs, a five-week study was conducted using a dried 18g needle, triplicate sample sets from 100 mL bottles received four new punctures per liner each week (5 weeks total) throughout the test schedule for a total of 20 punctures per liner. At the end of each interval, the overcaps were secured by torquing the cap using a force of 40 in-lbs.

Test Results (KF)











 

Other Test Solvents

Solvents Tested Average Weekly Moisture Gain (5 weeks)
Aldrich Sure/Seal Competitor A
Chloroform ~ 1.1 ppm ~ ~11.6 ppm
Dichloromethane ~ 2.2 ppm ~ 14.5 ppm
1,4-Dioxane ~ 4.2 ppm ~ 36.4 ppm
n-Hexane * <1 ppm change <1 ppm change
Pyridine ~ 5.4ppm ~45.3 ppm
Toluene ~ 1.7 ppm ~ 7.3ppm

 

 

* Virtually no change within testing variance. The initial water content was subtracted from successive testing values to normalize the concentration of water over time.

Comprehensive testing confirms the new Sure/Seal outperforms other products on the market by maintaining low water absorption even after multiple punctures.

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Linear Integrity
When using air-sensitive solvents and reagents, liners should not only seal to maintain product quality, but also consistently maintain form after repeated punctures. 

Toluene Testing – 5weeks (20 punctures)

Competitor A

New Aldrich Sure/Seal



n-Hexane Testing
New Sample
0 Punctures
Week 2
8 Punctures
Week 4
16 Punctures
Week 6
24 Punctures
Competitor A
New Aldrich Sure/Seal

Above photos illustrate the affects of repetitive punctures (4 per week) using a dried 18g needle

 

The new liner configuration from Sigma-Aldrich was not prone to upwardly swelling nor did it show evidence of bowing. It was apparent that Competitor A’s liner demonstrated dramatic liner damage during the repetitive puncture testing in both the Toluene and n-Hexane (however significant water gain was not observed in n-Hexane) samples.

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New Aldrich Sure/Seal Chemicals NOW Available from United States locations.
As we continue to package through out the year, you will begin to notice more and more anhydrous and air-sensitive reageants coming to you with the new design. Continue to check this page for the latest updates.



Product # Product Name Unit Size Add to Cart
494445 Acetonitrile, biotech. grade, ≥99.93% 494445-2L
401765 Benzene anhydrous, 99.8% 401765-100mL
401765-1L
401765-6x1L
305197 Benzyl alcohol, anhydrous, 99.8% 305197-100mL
305197-6x1L
305197-2L
281549 1-Butanol, anhydrous, 99.8% 281549-100mL
281549-1L
471712 tert-butanol, anhydrous, ≥99.5% 471712-100mL
186171 Butyllithium solution 1.6 M in hexanes 186171-50mL
186171-100mL
186171-800mL
186171-1L
230707 Butyllithium solution 2.5 M in hexanes 230707-50mL
230707-100mL
230707-800mL
180173 Carbon disulfide, ACS reagent, ≥99.9% 180173-500mL
154709 Carbon disulfide, spectrophotometric, ≥99% 154709-1L
154709-2L
284513 Chlorobenzene anhydrous, 99.8% 284513-100mL
284513-1L
284513-2L
288306 Chloroform, anhydrous, ≥99%, contains 0.5-1.0% ethanol as stabilizer 288306-2L
294772 Decahydronaphthalene, mixture of cis + trans, anhydrous, ≥99% 294772-100mL
457116 Decane anhydrous, ≥99% 457116-100mL
457116-1L
457116-2L
240664 1,2-Dichlorobenzene, anhydrous, 99% 240664-2L
284505 1,2-Dichloroethane anhydrous, 99.8% 284505-100mL
284505-12x100mL
284505-1L
284505-6x1L
284505-2L
296082 Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7% 296082-100mL
296082-1L
309966 Diethyl ether, for HPLC, ≥99.9%, inhibitor-free 309966-100mL
309958 Diethyl ether, spectrophotometric grade, ≥99.9%, inhibitor-free 309958-1L
271012 N,N-Dimethylacetamide anhydrous, 99.8% 271012-100mL
271012-12x100mL
271012-1L
271012-2L
227056 N,N-Dimethylformamide anhydrous, 99.8% 227056-100mL
227056-12x100mL
227056-1L
227056-6x1L
227056-2L
227056-4x2L
494488 N,N-Dimethylformamide, biotech. grade, ≥99.9% 494488-1L
494488-2L
276855 Dimethyl sulfoxide, anhydrous, ≥99.9% 276855-100mL
276855-1L
276855-6x1L
494429 Dimethyl sulfoxide, biotech. grade, 99.8% 494429-2L
297879 Dodecane anhydrous, ≥99% 297879-100mL
297879-1L
297879-2L
459836 Ethanol 200 proof, anhydrous, ≥99.5% 459836-100mL
459836-12x100mL
459836-1L
459836-6x1L
459836-2L
459836-4x2L
277649 Ethanol reagent, anhydrous, denatured 277649-100mL
277649-12x100mL
277649-1L
277649-6x1L
277649-2L
277649-4x2L
324558 Ethylene glycol, anhydrous, 99.8% 324558-100mL
324558-1L
324558-6x1L
324558-2L
246654 Heptane anhydrous, 99% 246654-100mL
246654-1L
296317 Hexadecane anhydrous, ≥99% 296317-100mL
296317-1L
296317-2L
296090 Hexane anhydrous, 95% 296090-100mL
296090-1L
296090-6x1L
296090-2L
227064 Hexane, mixture of isomers anhydrous, ≥99% 227064-1L
227064-2L
471402 1-Hexanol, anhydrous, ≥99% 471402-1L
322415 Methanol anhydrous, 99.8% 322415-100mL
322415-12x100mL
322415-1L
322415-6x1L
322415-2L
322415-4x2L
494437 Methanol, biotech. grade, 99.93% 494437-2L
284467 2-Methoxyethanol, anhydrous, 99.8% 284467-1L
277258 2-Methylbutane, anhydrous, ≥99% 277258-1L
309435 3-Methyl-1-butanol anhydrous, ≥99% 309435-100mL
309435-1L
296821 Nonane anhydrous, ≥99% 296821-100mL
296821-1L
296821-2L
296988 Octane anhydrous, ≥99% 296988-100mL
296988-1L
296988-2L
296988-4x2L
279544 1-Propanol anhydrous, 99.7% 279544-100mL
279544-1L
279544-2L
278475 2-Propanol anhydrous, 99.5% 278475-100mL
278475-12x100mL
278475-1L
278475-6x1L
278475-2L
371696 Tetrachloroethylene, anhydrous, ≥99% 371696-100mL
371696-1L
522651 1,2,3,4-Tetrahydronaphthalene, anhydrous, 99% 522651-1L
296104 1,2,4-Trichlorobenzene, anhydrous, ≥99% 296104-100mL
296104-1L
304050 Triethyl orthoformate, anhydrous, 98% 304050-100mL
304050-1L
305472 Trimethyl orthoformate, anhydrous, 99.8% 305472-1L
305472-2L
360066 2,2,4-Trimethylpentane, anhydrous, 99.8% 360066-1L
244511 Toluene anhydrous, 99.8% 244511-100mL
244511-12x100mL
244511-1L
24451-6x1L
244511-2L
244511-4x2L
296325 m-Xylene, anhydrous, ≥99% 296325-4x2L
294780 o-Xylene, anhydrous, 97% 294780-2L



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