Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Positron Emission Tomography

PET Applications

ISOTEC™ offers target materials for the production of radionuclides 18F, 11C, and 15O. In addition to the target materials, we also offer all reagents used in the production of 18FDG. PET research studies have various applications that include Cardiology, Oncology, Neurology, Pharmacology, and Neuropsychology and Cognitive Neuroscience.


Cardiology

 

PET is the most common form of diagnostic testing for use in cardiology, for example myocardial viability and coronary heart disease. The radionuclide 13N, produced from Water-16O (329886) is used in myocardial perfusion. PET scans help to differentiate viable myocardium from infracted tissue in patients that are suspected to have hibernating or stunned myocardium.

Oncology  

The onset of PET imaging has generated various interests with investigative studies in oncology using 18F-FDG. ISOTEC™ supplies the Water-18O (329878), Kryptofix® (291110), and the Mannose triflate (M1568) necessary to produce the 18F-FDG. Today, PET has distinctive uses in clinical areas such as cancers, lymphoma, melanoma, strokes, and tumors.

Neurology

 

PET is also used to distinguish recurrent brain tumors from radiation fibrosis or necrosis, which is essential to neurological studies. Oxygen-15O, produced from 15N2(99%)/Oxygen (RG) Gas Mix 39:1 (600911), measures the flow of blood to the upper or main portion of the brain. The isotope 11C, produced from 14N2 (608661), is used as a radiotracer in PET scans to study normal/abnormal brain functions. It is one of the methods in localizing areas of the brain affected by epileptic seizures.

Pharmacology  

In pre-clinical trials, PET has shown that it can provide researchers with the ability to produce radiolabeled drugs.

Neuropsychology and Cognitive Neuroscience Pharmacology

PET is used in clinical applications to study psychiatric disorders. There are now studies linking direct visualization of blunted regional brain responses to serotonin release with major depression. PET is also used to evaluate neurological activity in amnesiac patients.