Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.




Chemical Probes from The SGC

In your research, it is essential to ensure that your target is the right target. Sigma® Life Science has partnered with the Structural Genomics Consortium (SGC) to provide highly characterized, novel chemical probes for researching clinically relevant protein targets. These probes, developed and characterized by the SGC, meet strict criteria for potency, selectivity, and cell-permeability in order to be used as essential tools in preclinical target validation. Originally focusing on proteins involved in epigenetic control, including well-studied targets such as the bromodomain-containing BET family of proteins and histone methyltransferase EZH2, the SGC has expanded to include chemical probes for other research areas, including kinases, serine proteases and other protein families.

Backed by full characterization data from the SGC and the consistency and high quality of our Bioactive Small Molecule portfolio, SGC chemical probes allow you to validate your target with confidence. Explore the full offering of SGC chemical probes below.

 Probes for Bromodomains

Product No. Product Name Protein Target
SML0974 (+/-) JQ1 BRD2, BRD3, BRD4, BRDT (BET)
SML1524* (+) JQ1* BRD2, BRD3, BRD4, BRDT (BET)
SML0992 Bromosporine pan-Bromodomain
SML0939 PFI-3 SMARCA, PB1
SML1133 SGC-CBP30 CREBBP, EP300
SML1134 I-CBP112 CREBBP, EP300
SML1184 OF-1 BRPF1, BRPF2, BRPF3
SML0352 PFI-1 BRD2, BRD3, BRD4, BRDT (BET)
SML0768 GSK2801 BAZ2A, BAZ2B
SML1276 BAZ2-ICR BAZ2A, BAZ2B
PZ0307 PFI-4 BRPF1B
SML1486 NI-57 BRPF1, BRPF2, BRPF3
SML1534 I-BRD9 BRD9
SML1557 LP99 BRD9, BRD7
SML1655 BI-9564 BRD9, BRD7
SML1803 NVS-CECR2-1 CECR2
SML1756* BAY-299* BRD1, TAF1
SML1862 TP-472 BRD9, BRD7

*Negative control available, see table below.

 

 Probes for Methyltransferases

Product No. Product Name Protein Target
U4885 UNC0638 G9a/GLP
SML1107 SGC0946 DOT1L
SML1037 UNC0642 G9a/GLP
SML0778 UNC1999 EZH2
SML0766 GSK343 EZH2
SML1242 SGC707 PRMT3
SML1279 LLY-507 SMYD2
SML1408* (R)-PFI-2* SETD7
SML1410 A-366 G9a/GLP
SML1555 MS023 Type I PRMTs
SML1565 A-196 SUV420H1/H2
SML1553 MS049 PRMT4,6
SML1603 BAY-598 SMYD2
SML1751 GSK591 PRMT5
SML1849 TP-064 PRMT4

*Negative control available, see table below.

 

 Probes for Other Epigenetic Targets

Product No. Product Name Protein Target
SML0652 IOX2 Prolyl-hydroxylase (PHD)
SML0662 UNC1215 L3MBTL3
SML0709 GSK-J1 H3K27m3 demethylase
SML0701 GSK-J4 H3K27m3 demethylase
SML1072 GSK-LSD1 LSD1
SML0067 IOX1 pan 2-OG
SML1209 OICR-9429 WDR5
SML1658 GSK484 PAD-4

 

 Probes for Additional Targets

Product No. Product Name Protein Target
SML1563* BAY-678* Neutrophil elastase
SML1757 GSK864 Mutant IDH1
SML1774* BAY-876* GLUT1

*Negative control available, see table below.

 

 Negative controls

Product No. Product Name Active Chemical Probe
PZ0312 (S)-PFI-2 (R)-PFI-2 (SML1408)
SML1525 (-) JQ1 (+) JQ1 (SML1524)
SML1564 BAY-677 BAY-678 (SML1563)
SML1780 BAY-588 BAY-876 (SML1774)
SML1783 BAY-299N BAY-299 (SML1756)

 

 About the SGC

The SGC is a not-for-profit organization that partners public and private entities with the goal of conducting open-access research with relevance to drug discovery, placing a primary focus on elucidating the 3D structures of human protein and human parasite protein targets. Approximately 200 scientists from the Universities of Oxford and Toronto and nine pharmaceutical companies work to achieve this goal, making the structures, reagents and methods available to the public to facilitate further research on protein targets.

 Additional Resources

 
Bioactive Small Molecules
Explore the full offering of the Bioactive Small Molecule portfolio, including LOPAC™ and Pfizer compounds, and find additional resources for your reference.
 
 
LOPAC®1280
Learn more about the LOPAC library of high quality, ready to screen compounds for target characterization and assay validation.
 
 
DISCOVER
Discover the right bioactive small molecules for your area of research.


 
Pharma-developed Compounds
Over 800 pharma-developed approved therapeutics and drug candidates are available from Sigma. Find your molecule of interest here.


 
Browse the eHandbook
Over 100 peer-reviewed entries in the Handbook of Receptor Classification and Signal Transduction covering topics such as Non-Peptide Receptors, Ion Channels, and more as well as links to hundreds of related small molecules.
 
New Small Molecules
New small molecules products are added to the portfolio weekly. Browse the newly launched molecules by area of research.