| Basic Mechanism |
| Title |
Author / Journal |
Abstract |
| Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown. |
Moore C.B., et al.
Methods. Mol. Biol. 2010;629:141-58. |
abstract |
| The RNA silencing technology applied by lentiviral vectors in oncology. |
Sumimoto H., et al.
Methods Mol. Biol. 2010;614:187-99. |
abstract |
| Gene silencing by small regulatory RNAs in mammalian cells. |
Scherr M., et al.
Cell Cycle. 2007 Feb 15;6(4):444-9. Epub 2007 Feb 5. Review. |
abstract |
| The silent treatment: RNAi as a defense against virus infection in mammals. |
van Rij RP, Andino R.
Trends Biotechnol. 2006. Apr;24(4):186-93. Epub 2006. Feb 28. |
abstract |
| A Facile Lentiviral Vector System for Expression of Doxycycline-Inducible shRNAs: Knockdown of the Pre-miRNA Processing Enzyme Drosha. |
Aagaard L, et al.
Mol Ther. 2007. Feb 20. |
abstract |
| RNA interference has a role in regulating Drosophila telomeres. |
Casacuberta E, Pardue ML. Perrimon.
Genome Biol. 2006. 7(5):220. Epub 2006 May 31. Review. |
abstract |
| Is RNA interference involved in intrinsic antiviral immunity in mammals? |
Cullen BR.
Nat. Immunol. 2006. June; 7(6):563-7. Review. |
abstract |
| Gene silencing of virus replication by RNA interference. |
Miyano-Kurosaki N, Takaku H.
Handb Exp Pharmacol. 2006;(173):151-71. |
abstract |
| Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? |
Jaronczyk K, Carmichael JB, Hobman TC.
Biochem. J.. 2005 May 1;387(Pt 3):561-71. |
abstract |
| Viral delivery of recombinant short hairpin RNAs. |
Davidson BL, Harper SQ.
Methods Enzymol. 2005;392:145-73 |
abstract |
| Paradigms for conditional expression of RNA interference molecules for use against viral targets. |
Strayer DS, Feitelson M., Sun B., Matskevich AA.
Methods Enzymol. 2005;392:227-41 |
abstract |
| Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation. |
Hutvagner G.
FEBS Lett. 2005 Oct 31;579(26):5850-7 |
abstract |
| Uncovering RNAi mechanisms in plants: biochemistry enters the foray. |
Qi Y, Hannon GJ.
FEBS Lett. 2005 Oct 31;579(26):5899-903 |
abstract |
| Plant pathology and RNAi: a brief history. |
Lindbo JA, Dougherty WG.
Annu Rev Phytopathol. 2005;43:191-204 |
abstract |
| RNAi: the nuts and bolts of the RISC machine. |
Filipowicz W.
Cell. 2005 Jul 15;122(1):17-20 |
abstract |
| Molecular mechanisms of RNAi: implications for development and disease. |
Rao M, Sockanathan S.
Birth Defects Res C Embryo Today. 2005 Mar;75(1):28-42 |
abstract |
| RNAi-mediated pathways in the nucleus. |
Matzke MA, Birchler JA.
Nat Rev Genet. 2005 Jan;6(1):24-35 |
abstract |
| Dicing and slicing: the core machinery of the RNA interference pathway. |
Hammond SM.
FEBS Lett. 2005 Oct 31;579(26):5822-9 |
abstract |
| RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences. |
Robert VJ, Vastenhouw NL, Plasterk RH.
Cold Spring Harb Symp Quant Biol. 2004;69:397-402 |
abstract |
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| High-Throughput Screening |
| Title |
Author / Journal |
Abstract |
| A comparison of multiple shRNA expression methods for combinatorial RNAi. |
McIntyre G.J., et al.
Genet Vaccines Ther. 2011 Apr 17;9(1):9. [Epub ahead of print] |
abstract |
| A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments. |
Seyhan A.A., et al.
Mol. Biosyst. 2011 Apr 12. [Epub ahead of print] |
abstract |
| An RNAi screen identifies USP2 as a factor required for TNF-a induced NF-?B signaling. |
Metzig M., et al.
Int. J. Cancer. 2011 Apr 7. doi: 10.1002/ijc.26124. [Epub ahead of print] |
abstract |
| Second-Generation Sequencing Supply an Effective Way to Screen RNAi Targets in Large Scale for Potential Application in Pest Insect Control. |
Wang Y., et al.
PLoS One. 2011 Apr 11;6(4):e18644. |
abstract |
| RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity. |
Gilot D., et al.
PLoS One. 011 Mar 29;6(3):e18261. |
abstract |
| Large scale RNAi screen reveals that the Inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation. |
Wu N., et al.
J. Biol. Chem.. 2011 Apr 10. [Epub ahead of print] |
abstract |
| A genome-wide shRNA screen for new OxPhos related genes. |
Bayona-Bafaluy M.P., et al.
Mitochondrion. 2011 May;11(3):467-75. Epub 2011 Feb 1. |
abstract |
| Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation. |
Fan C., et al.
Leuk. Lymphoma. Mar;52(3):502-14. Epub 2011 Feb 1. |
abstract |
| RNAi-based functional pharmacogenomics. |
Tuzmen S., et al.
Methods Mol. Biol. 2011;700:271-90. |
abstract |
| Vigilance and validation: Keys to success in RNAi screening. |
Sigoillot F.D., et al.
ACS Chem. Biol. 2011 Jan 21;6(1):47-60. Epub 2010 Dec 28. Review. |
abstract |
| Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation. |
Bowles R., et al.
J. Immunol. Methods. 2010 Dec 15;363(1):21-8. Epub 2010 Sep 24. |
abstract |
| An effective method for controlling false discovery and false nondiscovery rates in genome-scale RNAi screens. J Biomol Screen. |
Zhang X.D.
Pub. 2010 Oct;15(9):1116-22. Epub 2010 Sep 20. |
abstract |
| High-throughput RNAi screening for N-glycosylation dependent loci in Caenorhabditis elegans. |
Struwe W.B., et al.
Methods Enzymol. 2010;480:477-93. Review. |
abstract |
| RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells. |
Arora S., et al.
Gynecol. Oncol. 2010 Sep;118(3):220-7. |
abstract |
| RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma. |
Arora S., et al.
Mol. Cancer. 2010 Aug 18;9:218. |
abstract |
| Discovery of novel cell proliferation-enhancing gene by random siRNA library based combinatorial screening. |
Xiong X., et al.
Comb. Chem. High Throughput Screen. 2010 Nov 1;13(9):798-806. |
abstract |
| Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. |
Duan Z., et al.
Cancer Lett. 2010 Jul 28;293(2):220-9. Epub 2010 Feb 9. |
abstract |
| Identification of inhibitors of HSF1 functional activity by high-content target-based screening. |
Au Q., et al.
J. Biomol. Screen. 2009 Dec;14(10):1165-75. |
abstract |
| Illuminating the host - how RNAi screens shed light on host-pathogen interactions. |
Prudêncio M., et al.
Biotechnol J. 2009 Jun;4(6):826-37. Review. |
abstract |
| Integrative analysis of genome-wide RNA interference screens. |
Berndt J.D., et al.
Sci. Signal. 2009 May 12;2(70):pt4. |
abstract |
| Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. |
Ganesan A.K., et al.
PLoS Genet. 2008 Dec;4(12):e1000298. Epub 2008 Dec 5. |
abstract |
| Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion. |
Huang X., et al.
BMC Syst Biol. 2008 Jun 13;2:49. |
abstract |
| From sequence to function: using RNAi to elucidate mechanisms of human disease. |
Author, et al.
Cell Death Differ. 2008 May;15(5):809-19. Epub 2008 Jan 18. |
abstract |
| An efficient and fully automated high-throughput transfection method for genome-scale siRNA screens. |
Chung N., et al.
J. Biomol. Screen. 2008 Feb;13(2):142-8. Epub 2008 Jan 23. |
abstract |
| Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. |
Perrimon N, Friedman A, Mathey-Prevot B, Eggert US.
Drug Discov Today. 2007 Jan;12(1-2):28-33. Epub 2006 Oct 30 |
abstract |
| MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. |
Lage H.
Curr Drug Targets. 2006. Jul; 7(7):813-21. Review. |
abstract |
| High-throughput RNAi Screening in Cultured Cells: A User's Guide. |
Echeverri, C. and N. Perrimon.
Nature Reviews Genetics. 2006. 7, 373-384. |
abstract |
| From genome to phenome--RNAi library screening and hit characterization using signaling pathway analysis. |
Chatterjee-Kishore M.
Curr Opin Drug Discov Devel. 2006 Mar;9(2):231-9. |
abstract |
| High-throughput RNA interference in functional genomics |
Janitz M, Vanhecke D, Lehrach H.
Handb Exp Pharmacol. 2006;(173):97-104. |
abstract |
| Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation. |
Chatterjee-Kishore M, Miller CP.
Drug Discov Today. 2005 Nov 15;10(22):1559-65 |
abstract |
| Genome-wide application of RNAi to the discovery of potential drug targets. |
Ito M, Kawano K, Miyagishi M, Taira K.
FEBS Lett. 2005 Oct 31;579(26):5988-95 |
abstract |
| Genome-wide screening for gene function using RNAi in mammalian cells. |
Cullen LM, Arndt GM.
Immunol Cell Biol. 2005 Jun;83(3):217-23 |
abstract |
| RNAi and HTS: exploring cancer by systematic loss-of-function. |
Willingham AT, Deveraux QL, Hampton GM, Aza-Blanc P.
Oncogene. 2004 Nov 1;23(51):8392-400 |
abstract |
| Oncology studies using siRNA libraries: the dawn of RNAi-based genomics. |
Sachse C, Echeverri CJ.
Oncogene. 2004 Nov 1;23(51):8384-91 |
abstract |
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| IPTG Inducible shRNA |
| Title |
Author / Journal |
Abstract |
| FOXO3a Is A Major Target Of Inactivation By PI3K/AKT Signaling In Aggressive Neuroblastoma |
Santo, E.E., et al.
Cancer Res. 2013 Feb 1. [Epub ahead of print]
|
abstract |
Shifting the Paradigm: The Putative Mitochondrial Protein ABCB6 Resides in the Lysosomes of Cells and in the Plasma Membrane of Erythrocytes
|
Kiss, K., et al.
PLoS One. 2012; 7(5) |
abstract |
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| In Vivo Applications |
| Title |
Author / Journal |
Abstract |
| Knock-down of gene expression in hematopoietic cells. |
Scherr M., et al.
Methods Mol Biol. 2009;506:207-19. |
abstract |
| Reversible suppression of an essential gene in adult mice using transgenic RNA interference. |
McJunkin K., et al.
Proc. Natl. Acad. Sci. USA. 2011 Apr 11. [Epub ahead of print] |
abstract |
| Asymmetric cell divisions promote Notch-dependent epidermal differentiation. |
Williams, S.E., et al. Nature. 2011 Feb 17; 470 (7334): 353-358. |
abstract |
| Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. |
Beronja, S., et al. Nat Med. 2010 Jul; 16(7):821-827. |
abstract
video |
| Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis. |
Azmi, A.S., et al.
Mol Cancer Ther. 2008 Sep;7(9):2884-93. |
abstract |
| Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles. |
Bartlett, D.W., et al.
Biotechnol Bioeng. 2008
Mar 1;99(4):975-85. |
abstract |
| A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to Experimental Colitis. |
Boirivant, M., et al.
Gastroenterology. 2008 Aug 5. [Epub ahead of print] |
abstract |
| Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention. |
Chiu, C.C., et al.
Mol Cancer Ther. 2008 Sep;7(9):2788-97. |
abstract |
| Tumor necrosis factor alpha small interfering RNA decreases herpes simplex virus-induced inflammation in a mouse model. |
Choi, B., et al.
J Dermatol Sci. 2008 Nov;52(2):87-97. Epub 2008 Jun 27. |
abstract |
| Delivery vehicles for small interfering RNA in vivo. |
de Fougerolles, A.R.
Hum Gene Ther. 2008 Feb;19(2):125-32. |
abstract |
| Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in vitro and Rapidly Growing Tumors in vivo. |
Guo, A.M., et al.
J Pharmacol Exp Ther. 2008 Jun 30. [Epub ahead of print] |
abstract |
| Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. |
Hickerson, R.P., et al.
J Invest Dermatol. 2008 Mar;128(3):594-605. Epub 2007 Oct 11. |
abstract |
| A small interfering RNA targeting proteinase-activated receptor-2 is effective in suppression of tumor growth in a Panc1 xenograft model. |
Iwanki, K., et al.
Int J Cancer. 2008 Feb 1;122(3):658-63. |
abstract |
| Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF. |
Jiang, J., et al.
J Cell Physiol. 2008 Sep 2. [Epub ahead of print] |
abstract |
| Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer. |
Kawata, E., et al.
Mol Cancer Ther. 2008 Sep;7(9):2904-12. |
abstract |
| Silencing HIV-1 In Vivo. |
Kirchhoff, F.
Cell. 2008 Aug 22;134(4):566-8. |
abstract |
| Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. |
Kleinman, M.E., et al.
Nature. 452, 591-7 (2008). |
abstract |
| Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma. |
Jiang, L., et al.
Int J Cancer. Oct 2008; 123(8): 1779-86. |
abstract |
| Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. |
Luo, G.H., et al.
Transplant Proc. 2008 Sep;40(7):2365-9. |
abstract |
| Misinterpreting the therapeutic effects of siRNA caused by immune stimulation. |
Robbins, M., et al.
Hum Gene Ther. Aug 19. [Epub ahead of print] (2008). |
abstract |
| A dominant role of GTRAP3-18 in neuronal glutathione synthesis. |
Watabe, M., et al.
J Neurosci. 2008 Sep 17;28(38):9404-13. |
abstract |
| Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration. |
Yang, Z., et al.
N Engl J Med. Aug 27. [Epub ahead of print] (2008). |
abstract |
| Down-regulation of beta1-adrenoceptors gene expression by short interfering RNA impairs the memory retrieval in the basolateral amygdala of rats. |
Fu, A.L., et al.
Neurosci Lett. 2007 Nov 27;428(2-3):77-81. Epub 2007 Sep 26. |
abstract |
| In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery. |
Golzio, M., et al.
Gene Ther. 2007 May;14(9):752-9. Epub 2007 Mar 8. |
abstract |
| Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA. |
Inoue, T., et al.
J Gene Med. 2007 Nov;9(11):994-1001. |
abstract |
| Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I. |
Kim, S.I., et al.
Mol Ther. 2007 Jun;15(6):1145-52. Epub 2007 Apr 17. |
abstract |
| Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. |
Lasek, A.W., et al.
Genes Brain Behav. 2007. Mar 26. |
abstract |
| Therapeutic RNA interference of malignant melanoma by electrotransfer of small interfering RNA targeting Mitf. |
Nakai, N., et al.
Gene Ther. 2007 Feb;14(4):357-65. Epub 2006 Oct 5. |
abstract |
| Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. |
Pirollo, K.F., et al.
Cancer Res. 2007 Apr 1;67(7):2938-43. |
abstract |
| Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. |
Rozema, D.B., et al.
Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12982-7. Epub 2007 Jul 24. |
abstract |
| A high throughput in vivo model for testing delivery and antiviral effects of siRNAs in vertebrates. |
Schyth, B.D., et al.
Mol Ther. 2007 Jul;15(7):1366-72. Epub 2007 May 1. |
abstract |
| RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. |
Segura, T., et al.
J Surg Res. 2007 Aug;141(2):162-70. Epub 2007 Jun 11. |
abstract |
| Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. |
Shaw, A.T., et al.
Genes Dev. 2007. Mar 15;21(6):694-707. |
abstract |
| Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome. |
Watanabe, T., et al.
J Hepatol. 2007 Dec;47(6):744-50. Epub 2007 Jul 26. |
abstract |
| Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C. |
Yogota, T., et al.
Biochem Biophys Res Commun. 2007 Sep 21;361(2):294-300. Epub 2007 Jul 16. |
abstract |
| Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs. |
Aigner, A.
J Biotechnology. 2006. Jun 25; 124(1): 12-25. |
abstract |
| Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. |
Bartlett, D.W., et al.
Nucleic Acids Res. 2006 Jan 12;34(1):322-33. Print 2006. |
abstract |
| A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)(HXB2) Rev/Env or codon-optimized HIV-1(JR-FL) gp120 generates durable immune responses in mice. |
Buffa. V., et al.
J Gen Virol. 2006 Jun;87(Pt 6):1625-34. |
abstract |
| In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency. |
Carbonaro, D.A., et al.
Mol Ther. 2006 Apr 29; [Epub ahead of print] |
abstract |
| RNA interference in cancer. |
Gartel, A.L., et al.
Biomol Eng. 2006 Mar;23(1):17-34. Epub 2006 Feb 8. |
abstract |
| RNA interference: a potential therapeutic tool for silencing splice isoforms linked to human diseases. |
Gaur, R.K.
Biotechniques. 2006 Apr;Suppl:15-22. Review. |
abstract |
| Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. |
Guo, W., et al.
J Neurosci. 2006 Jan 4;26(1):126-37. |
abstract |
| RNA interference: its use as antiviral therapy. |
Haasnoot, J., et al.
Handb Exp Pharmacol. 2006;(173):117-50. |
abstract |
| RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. |
Howard, K.A., et al.
Mol Ther. 2006 Oct;14(4):476-84. Epub 2006 Jul 10. |
abstract |
| Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). |
Jha, P., et al.
J Immunol. 2006 Jun 15;176(12):7221-31. |
abstract |
| A single siRNA suppresses fatal encephalitis induced by two different flaviviruses. |
Kumar, P., et al.
PLoS Med. 2006 Apr;3(4):e96. Epub 2006 Feb 14. |
abstract |
| Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. |
McNamara, J.O., 2nd, et al.
Nat Biotechnol. 2006 Aug;24(8):1005-15. Epub 2006 Jun 25. |
abstract |
| RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. |
Modlinger, P., et al.
Hypertension. 2006 Feb;47(2):238-44. Epub 2006 Jan 3. |
abstract |
| Antiviral applications of RNAi. |
Morris K.V., and Rossi J.J.
Curr Opin Mol Ther. 2006 Apr; 8(2):115-21. Review. |
abstract |
| Antiviral applications of RNAi. |
Morris K.V., and Rossi J.J.
Handb Exp Pharmacol. 2006;(173):105-16 |
abstract |
| Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF). |
Murata, M., et al.
Curr Eye Res. 2006 Feb;31(2):171-80. |
abstract |
| An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. |
Palliser, D., et al.
Nature. 2006 Jan 5;439(7072):89-94. Epub 2005 Nov 23. |
abstract |
| RNA interference-mediated prevention and therapy for hepatocellular carcinoma. |
Romano, P.R., et al.
Oncogene. 2006. Jun 26; 25(27): 3857-65. Review. |
abstract |
| Therapeutic potential of RNAi in metabolic diseases. |
Rondinone, C.M.
Biotechniques. 2006 Apr; Suppl:31-6. Review. |
abstract |
| RNAi as a treatment for HIV-1 infection. |
Rossi, J.J.
Biotechniques. 2006 Apr; Suppl:25-9. Review. |
abstract |
| A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. |
Santel, A., et al.
Gene Ther. 2006 Aug;13(16):1222-34. Epub 2006 Apr 20. |
abstract |
| Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma. |
Toub, N., et al.
Pharm Res. 2006 May;23(5):892-900. Epub 2006 May 2. |
abstract |
| In Vivo Gene Transfer into Adult Stem Cells in Unconditioned Mice by in Situ Delivery of a Lentiviral Vector. |
Worsham, D.N., et al.
Mol Ther. 2006. 14: 514-24. |
abstract |
| RNAi-mediated gene silencing in non-human primates. |
Zimmermann, T.S., et al.
Nature. 2006 May 4;441(7089):111-4. Epub 2006 Mar 26. |
abstract |
| RNAi-induced gene silencing by local electroporation in targeting brain region. |
Akaneya, Y., et al.
J Neurophysiol. 2005 Jan;93(1):594-602. |
abstract |
| RNAi as an antiviral therapy. |
Bagasra, O.
Expert Opin Biol Ther. 2005 Nov;5(11):1463-74. Review. |
abstract |
| Use of RNA interference to prevent lethal murine west nile virus infection. |
Bai, F., et al.
J Infect Dis. 2005 Apr 1;191(7):1148-54. Epub 2005 Feb 23. |
abstract |
| Inhibition of respiratory viruses by nasally administered siRNA. |
Bitko, V., et al.
Nat Med. 2005 Jan;11(1):50-5. Epub 2004 Dec 26. |
abstract |
| State-of-the-art modified RNAi compounds for therapeutics. |
Carstea, E.D., et al.
IDrugs. 2005 Aug;8(8):642-7. |
abstract |
| Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo. |
Chein, P.Y., et al.
Cancer Gene Ther. 2005 Mar;12(3):321-8. |
abstract |
| Silencing viruses by RNA interference. |
Colboere-Garapin, F., et al.
Microbes Infect. 2005 Apr;7(4):767-75. |
abstract |
| Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. |
Filleur, S., et al.
Cancer Res. 2005 Jun 15;65(12):5144-52. |
abstract |
| Delivering RNA interference to the mammalian brain. |
Fountaine, T.M., et al.
Curr Gene Ther. 2005 Aug;5(4):399-410. |
abstract |
| RNA interference & inhibition of viruses. |
Gadkari, D.A.
Indian J Med Res. 2005 Mar;121(3):147-50. |
abstract |
| A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. |
Guan, H., et al.
Clin Cancer Res. 2005 Apr 1;11(7):2662-9. |
abstract |
| Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney. |
Hassan, A., et al.
Physiol Genomics. 2005 May 11;21(3):382-8. Epub 2005 Mar 22. |
abstract |
| RNA interference for treating haematological malignancies. |
Hexner, E.O., and Gewirtz, A.M.
Expert Opin Biol Ther. 2005 Dec;5(12):1585-92. Review. |
abstract |
| Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. |
Hu-Lieskovan, S., et al.
Cancer Research. 2005, 65, 8984-92. |
abstract |
| Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin. |
Ito, M., et al.
J Gene Med. 2005 Aug;7(8):1044-52. |
abstract |
| Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency. |
Kim, T.W., et al.
Cancer Res. 2005 Jan 1;65(1):309-16. |
abstract |
| Potential applications of RNA interference technology in the treatment of cancer. |
Lage, H.
Future Oncol. 2005 Feb;1(1):103-13. Review. |
abstract |
| Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo. |
Leng, Q., et al.
Cancer Gene Ther. 2005 Aug;12(8):682-90. |
abstract |
| Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. |
Li, B.J., et al.
Nature Medicine. 2005,9, 944-951. |
abstract |
| Silencing of CXCR4 blocks breast cancer metastasis. |
Liang, Z., et al.
Cancer Res. 2005 Feb 1;65(3):967-71. |
abstract |
| Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. |
Lingor, P., et al.
Brain. 2005 Mar;128(Pt 3):550-8. Epub 2005 Jan 19. |
abstract |
| Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury. |
Lomas-Neira, J., et al.
Cytokine. 2005 Aug 7;31(3):169-79. |
abstract |
| In vivo application of RNA interference: from functional genomics to therapeutics. |
Lu, P.Y., et al.
Adv Genet. 2005;54:117-42. |
abstract |
| An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. |
Luo, M.C., et al.
Mol Pain. 2005 Sep 28;1:29. |
abstract |
| In vitro and in vivo suppression of GJB2 expression by RNA interference. |
Maeda, Y., et al.
Hum Mol Genet. 2005 Jun 15;14(12):1641-50. Epub 2005 Apr 27. |
abstract |
| Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice. |
Merl, S., et al.
Circulation. 2005 Apr 5;111(13):1583-92. Epub 2005 Mar 28. |
abstract |
| Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors. |
Moore, M., et al.
J Gene Med. 2005 Jul;7(7):918-25. |
abstract |
| Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. |
Morrissey, D.V., et al.
Nat Biotechnol. 2005 Aug;23(8):1002-7. Epub 2005 Jul 24. |
abstract |
| Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. |
Nogawa, M., et al.
J Clin Invest. 2005 Apr;115(4):978-85. Epub 2005 Mar 10. |
abstract |
| Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer. |
Ocker, M., et al.
Gut. 2005 Sep;54(9):1298-308. |
abstract |
| Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. |
Pal, A., et al.
Int J Oncol. 2005 Apr;26(4):1087-91. |
abstract |
| Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. |
Pillé, J.Y., et al.
Mol Ther. 2005 Feb;11(2):267-74. |
abstract |
| Progress toward the therapy of hepatitis with RNAi. |
Rendall, G.
Hepatology. 2005 Jun;41(6):1220-2. |
abstract |
| Gene silencing in rat-liver and limb grafts by rapid injection of small interference RNA. |
Sato, Y., et al.
Transplantation. 2005 Jan 27;79(2):240-3. |
abstract |
| Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. |
Schiffelers, R.M., et al.
Arthritis Rheum. 2005 Apr;52(4):1314-8. |
abstract |
| Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. |
Sharma, A., et al.
Cancer Res. 2005 Mar 15;65(6):2412-21. |
abstract |
| Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. |
Song, E., et al.
Nat Biotechnol. 2005 Jun;23(6):709-17. Epub 2005 May 22. |
abstract |
| RNA interference-based gene silencing in mice: the development of a novel therapeutical strategy. |
Spänkuch, B., et al.
Curr Pharm Des. 2005;11(26):3405-19. |
abstract |
| Exploring RNA interference as a therapeutic strategy for renal disease. |
Takabatake, Y., et al.
Gene Ther. 2005 Jun;12(12):965-73. |
abstract |
| Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. |
Takeshita, F., et al.
Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12177-82. Epub 2005 Aug 9. |
abstract |
| Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat. |
Tan, P.H., et al.
Gene Therapy. 2005, 12, 59-66. |
abstract |
| siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain. |
Thakker, D.R., et al.
Mol Psychiatry. 2005 Aug;10(8):782-9, 714. |
abstract |
| Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. |
Uprichard, S., et al.
Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):773-8. |
abstract |
| RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. |
Urban-Klein, B., et al.
Gene Ther. 2005 Mar;12(5):461-6. |
abstract |
| Biology calls the targets: combining RNAi and disease biology. |
van Es H.H., and Arts, G.J.
Drug Discov Today. 2005 Oct 15;10(20):1385-91. Review. |
abstract |
| Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA. |
Wang, Y.L., et al.
Neurosci Res. 2005 Nov;53(3):241-9. Epub 2005 Aug 10. |
abstract |
| In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. |
Wesche-Soldato, D.E., et al.
Blood. 2005 Oct 1;106(7):2295-301. Epub 2005 Jun 7. |
abstract |
| EphB4 expression and biological significance in prostate cancer. |
Xia, G., et al.
Cancer Res. 2005 Jun 1;65(11):4623-32. |
abstract |
| Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. |
Aharinejad, S., et al.
Cancer Res. 2004 Aug 1;64(15):5378-84. |
abstract |
| RNA interference as a potential tool in the treatment of leukaemia. |
Borkhardt, A., and Heidenreich, O.
Expert Opin Biol Ther. 2004 Dec;4(12):1921-9. |
abstract |
| Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. |
Chae, S.S., et al.
J Clin Invest. 2004 Oct;114(8):1082-9. |
abstract |
| Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. |
Contreras, J.L., et al.
Surgery. 2004 Aug;136(2):390-400. |
abstract |
| siRNA relieves chronic neuropathic pain. |
Dorn, G., et al.
Nucleic Acids Res. 2004 Mar 16;32(5):e49. |
abstract |
| EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma. |
Duxbury, M.S., et al.
Oncogene. 2004 Feb 19;23(7):1448-56. |
abstract |
| Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer. |
Duxbury, M.S., et al.
Ann Surg. 2004 Oct;240(4):667-74; discussion 675-6. |
abstract |
| Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. |
Flynn, M.A., et al.
J Inflamm (Lond). 2004 Oct 1;1(1):4. |
abstract |
| Inhibition of influenza virus production in virus-infected mice by RNA interference. |
Ge, Q., et al.
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8676-81. Epub 2004 Jun 1. |
abstract |
| Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery. |
Golzio, M., et al.
Gene Therapy. 2004, 12, 246-251. |
abstract |
| A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. |
Hagstrom, J.E., et al.
Molecular Therapy. 2004, 10, 386-398. |
abstract |
| Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. |
Hamar, P., et al.
Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14883-8. Epub 2004 Oct 4. |
abstract |
| Lack of interferon response in animals to naked siRNAs. |
Heidel, J., et al.
Nature Biotechnology. 2004, 22, 1579-1582 |
abstract |
| Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. |
Kim, B., et al.
Am J Pathol. 2004 Dec;165(6):2177-85. |
abstract |
| Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. |
Kong, X.C., et al.
EMBO Report. 2004, 5, 183-188. |
abstract |
| In vivo activity of nuclease-resistant siRNAs. |
Layzer, J.M., et al.
RNA. 2004, 10, 766-771. |
abstract |
| Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice. |
Massaro, D., et al.
Am. J. Physiol. Lung. Cell. Mol. Physiol. 2004, 287, L1066-L1070. |
abstract |
| Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. |
Minakuchi, Y., et al.
Nucleic Acids Res. 2004 Jul 22;32(13):e109. |
abstract |
| RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. |
Nakamura, H., et al.
Mol Vis. 2004 Oct 4;10:703-11. |
abstract |
| Challenges for RNAi in vivo. |
Paroo, Z., and Corey, D.R.
Trends Biotechnol. 2004 Aug;22(8):390-4. |
abstract |
| RNAi knock-down mice: an emerging technology for post-genomic functional genetics. |
Prawitt, D., et al.
Cytogenet Genome Res. 2004;105(2-4):412-21. |
abstract |
| Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. |
Schiffelers, R.M., et al.
Nucleic Acids Res. 2004 Nov 1;32(19):e149. |
abstract |
| Systemic delivery of synthetic siRNAs. |
Sioud, M., and Sørensen, D.R.
Methods Mol Biol. 2004;252:515-22. |
abstract |
| Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. |
Soutschek, J., et al.
Nature. 2004 Nov 11;432(7014):173-8. |
abstract |
| Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1. |
Spänkuch, B., et al.
J Natl Cancer Inst. 2004 Jun 2;96(11):862-72. |
abstract |
| A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. |
Takei, Y., et al.
Cancer Res. 2004 May 15;64(10):3365-70. |
abstract |
| RNAi, a new therapeutic strategy against viral infection. |
Tan, F.L., and Yin, J.Q.
Cell Res. 2004 Dec;14(6):460-6. |
abstract |
| Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. |
Thakker, D.R., et al.
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17270-5. Epub 2004 Nov 29. |
abstract |
| Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization. |
Tolentino, M.J., et al.
Retina. 2004, 24, 132-138. |
abstract |
| Protection against lethal influenza virus challenge by RNA interference in vivo. |
Tompkins, S.M., et al.
Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8682-6. Epub 2004 Jun 1. |
abstract |
| Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer. |
Yano, J., et al.
Clin Cancer Res. 2004 Nov 15;10(22):7721-6. |
abstract |
| Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. |
Zhang, X., et al.
J Biol Chem. 2004 Mar 12;279(11):10677-84. Epub 2003 Dec 18. |
abstract |
| RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. |
Duxbury, M.S., et al.
Biochem Biophys Res Commun. 2003 Nov 21;311(3):786-92. |
abstract |
| SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. |
Filleur, S., et al.
Cancer Research. 2003, 63, 3919-3922. |
abstract |
| Small interfering RNA inhibits hepatitis B virus replication in mice. |
Giladi, H., et al.
Mol Ther. 2003 Nov;8(5):769-76. |
abstract |
| Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. |
Klein, C., et al.
Gastroenterology. 2003 Jul;125(1):9-18. |
abstract |
| Inhibition of Hepatitis B virus in mice by RNA interference. |
McCaffrey, A.P., et al.
Nature Biotechnology. 2003, 21, 639-644. |
abstract |
| Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. |
Reich, S.J., et al.
Mol Vis. 2003 May 30;9:210-6. |
abstract |
| RNA interference targeting Fas protects mice from fulminant hepatitis. |
Song, E., et al.
Nat Med. 2003 Mar;9(3):347-51. Epub 2003 Feb 10. |
abstract |
| Gene silencing by systemic delivery of synthetic siRNAs in adult mice. |
Sørensen, D.R., et al.
J Mol Biol. 2003 Apr 4;327(4):761-6. |
abstract |
| Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. |
Verma, U.N., et al.
Clin Cancer Res. 2003 Apr;9(4):1291-300. |
abstract |
| Caspase 8 small interfering RNA prevents acute liver failure in mice. |
Zender, L., et al.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7797-802. Epub 2003 Jun 16. |
abstract |
| Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis. |
Baker-Herman, T.L., et al.
J Neurosci. 2002 Jul 15;22(14):6239-46. |
abstract |
| Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo. |
Bertrand, J.R., et al.
Biochem Biophys Res Commun. 2002 Aug 30;296(4):1000-4. |
abstract |
| Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. |
Lewis, D.L., et al.
Nat Genet. 2002 Sep;32(1):107-8. Epub 2002 Jul 29. |
abstract |
| Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. |
Lewis, D.L., et al.
Nature Genetics. 2002, 21, 639-644. |
abstract |
| Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. |
Makimura, H., et al.
BMC Neurosci. 2002 Nov 7;3:18. |
abstract |
| RNA interference in adult mice. |
McCaffrey, A.P., et al.
Nature. 2002 Jul 4;418(6893):38-9. |
abstract |
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| In Vivo Disease Treatment |
| Title |
Author / Journal |
Abstract |
| Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. |
Possemato R., et al.
Nature.. 2011. Aug;476:346-350. |
abstract |
| Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference. |
Sang W., et al.
Immunol Lett.. 2011. May;136(2):194-202. Epub 2011 Jan 26. |
abstract |
| Therapeutic regulation of gene expression in the inner ear using RNA interference. |
Maeda Y., et al.
Adv. Otorhinolaryngol.. 2009;66:13-36. Epub 2009 Jun 2. Review. |
abstract |
| Silencing the breast cancer resistance protein expression and function in caco-2 cells using lentiviral vector-based short hairpin RNA. |
Zhang W., et al.
Drug Metab. Dispos.. 2009 Apr;37(4):737-44. Epub 2009 Jan 8. |
abstract |
| Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication. |
Gao Y., et al.
J. Virol.. 2008 Mar;82(6):2938-51. Epub 2008 Jan 16. |
abstract |
| RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors. |
Schaser T., et al.
Gene Ther.. 2011. Apr 7. [Epub ahead of print] |
abstract |
| Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells. |
Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R.
Mol Ther. 2007. Apr 3. |
abstract |
| Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. |
Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN.
J Neurosci Methods. 2007. Mar 3. |
abstract |
| Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors. |
Greenberg KP, et al.
Invest Ophthalmol Vis Sci. 2007. Apr;48(4):1844-52. |
abstract |
| Target validation using RNA interference in solid tumors. |
Aharinejad S, et al.
Methods Mol Biol. 2007;361:227-38. Review. |
abstract |
| Gene delivery to airway epithelial cells in vivo: a direct comparison of apical and basolateral transduction strategies using pseudotyped lentivirus vectors. |
Kremer KL, et al.
J Gene Med. 2007. Mar 22. |
abstract |
| RNAi therapy for neurodegenerative diseases. |
Boudreau RL, Davidson BL
Curr Top Dev Biol. 2006. 75: 73-92. Review. |
abstract |
| Interference RNA technology in the treatment of CNV. |
Tolentino M
Ophthalmol Clin North Am. 2006. Sep; 19(3): 393-9, vi-vii. Review. |
abstract |
| RNA interference: a potential revolution in disease therapy. |
Waseem T.
J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review. |
abstract |
| Correction of Cardiac Abnormalities in Fabry Mice by Direct Intraventricular Injection of a Recombinant Lentiviral Vector that Engineers Expression of alpha-Galactosidase A. |
Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA.
Circ J. 2006. Nov; 70(11): 1503-8. |
abstract |
| back to top |
| MISSION® siRNA Publications |
| Title |
Author / Journal |
Abstract |
| RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity |
Gilot, D. et al.
PLoS ONE 2011, 6(3). |
e18261 |
| Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts |
Meng, W. et al.
Cell 2008 Nov. 28, 135(5), 948-59. |
abstract |
| BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation |
Matsubara, T. et al.
J. Biol. Chem. 2008 Oct., 283(43), 29119-25. Epub 2008 Aug, 14. |
abstract |
| Genome-Scale RNAi Screen for Host Factors Required for HIV Replication |
Zhou, H. et al.
Cell Host Microbe 2008 Oct 29. [Epub ahead of print]. |
abstract |
| Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. |
Bartz. S.R., et al.,
Mol Cell Biol. 2006. 26: 9377-86. |
abstract |
| Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. |
Chajès, V., et al.,
Cancer Res. 2006.66: 5287-94. |
abstract |
| A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. |
Espeseth, A.S., et al.,
Mol Cell Neurosci. 2006.33: 227-35. |
abstract |
| Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. |
Kim, E.J., et al.,
J Biol Chem. 2006.281:33250-7. |
abstract |
| Cleavage of the siRNA passenger strand during RISC assembly in human cells. |
Leuschner, P.J., et al.,
EMBO Rep. 2006.7: 314-20. |
abstract |
| A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. |
Miserey-Lenkei, S., et al.,
EMBO J. 2006.25: 278-89. |
abstract |
| BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. |
Moreau, K., et al.,
J Biol Chem. 2006.281: 3172-81. |
abstract |
| Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA. |
Poncet, D, et al.,
J Cell Biol. 2006.174: 985-96. |
abstract |
| RalB mobilizes the exocyst to drive migration. |
Rossé, C., et al.,
Mol Cell Biol. 2006.26: 727-34. |
abstract |
| The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. |
Wang, F., et al.,
Mol Cell Biol. 2006. 26: 4028-40. |
abstract |
| Induction of centrosome amplification during arsenite-induced mitotic arrest in CGL-2 cells. |
Yih, L.H., et al.,
Cancer Res. 2006.66: 2098-106. |
abstract |
| A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages |
Colucci-Guyon, E., et al.,
Curr Biol. 2005.15: 2007-12. |
abstract |
| A vital role of tubulin-tyrosine-ligase for neuronal organization. |
Erck, C., et al.,
Proc Natl Acad Sci U S A. 2005. 102:7853-8. |
abstract |
| Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization. |
Etienne-Manneville, S., et al.,
J Cell Biol. 2005.170: 895-901. |
abstract |
| Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma. |
Guida, T., et al.,
J Clin Endocrinol Metab. 2005.90 (8):4703-9. |
abstract |
| Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. |
Johnson. J., et al.,
RNA. 2005.11: 1737-44. |
abstract |
| Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively. |
Porta, C., et al.,
Oncogene 2005.24: 605-15. |
abstract |
| RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. |
Putral, L.N., et al.,
Mol Pharmacol. 2005.68:1311-9. |
abstract |
| Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. |
Shiraishi, T., et al.,
Cancer Res. 2005.65: 6364-70. |
abstract |
| Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. |
Stapelberg, M., et al.,
J Biol Chem. 2005.280: 25369-76. |
abstract |
| Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA. |
Terasaki, T., et al.,
J Neurochem. 2005. 93: 63-71. |
abstract |
| Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif. |
Darnell, G.A., et al.,
Mol Cell Biol. 2003.23: 6520-32. |
abstract |
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| Specific Applications |
| Title |
Author / Journal |
Abstract |
| Mpz gene suppression by shRNA increases Schwann cell apoptosis in vitro. |
Lei L., et al.
Neurol Sci.. 2010 Oct;31(5):603-8. Epub 2010 Jun 15. |
abstract |
| A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. |
Zhang J., et al.
RNA. 2007 Aug;13(8):1375-83. Epub 2007 Jul 6. |
abstract |
| Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. |
Chen Y., et al.
Hepatology. 2007 Jul;46(1):200-8. Erratum in: Hepatology. 2007 Oct;46(4):1314. |
abstract |
| STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo. |
Huang C., et al.
Int. J. Oncol. 2011 Jun;38(6):1637-44. doi: 10.3892/ijo.2011.1000. Epub 2011 Apr 8. |
abstract |
| Lentiviral-mediated Smad4 RNAi promotes SMMC-7721 cell migration by regulation of MMP-2, VEGF and MAPK signaling. |
Huang X., et al.
Mol. Med. Report. 2010 Mar-Apr;3(2):295-9. doi: 10.3892/mmr_00000254 |
abstract |
| RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation. |
Walsh N., et al.
Cancer Lett. 2011 Apr 4. [Epub ahead of print] |
abstract |
| Down-Regulation of TNF-Alpha by Small Interfering RNA Inhibits Particle-Induced Inflammation In Vitro. |
Qin C.Q., et al.
Artif. Organs. 2011 Apr 19. doi: 10.1111/j.1525-1594.2010.01175.x. [Epub ahead of print] |
abstract |
| Nicotine Induces Pro-inflammatory Response in Aortic Vascular Smooth Muscle Cells Through a NF?B/Osteopontin Amplification Loop-Dependent Pathway. |
Wang Y., et al.
Inflammation. 2011 Apr 15. [Epub ahead of print] |
abstract |
| beta Cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery. |
McCabe C, O'Brien T.
Biochem. Biophys. Res. Commun.. 2007 May 25;357(1):75-80. Epub 2007 Mar 28. |
abstract |
| Trophoblast-specific gene manipulation using lentivirus-based vectors. |
Georgiades P, et al.
Biotechniques. 2007. Mar;42(3):317-8, 320, 322-5. |
abstract |
| Suppression of PPAR{gamma} Attenuates Insulin-Stimulated Glucose Uptake by Affecting Both GLUT1 and GLUT4 in 3T3-L1 Adipocytes. |
Liao W, et al.
Am J Physiol Endocrinol Metab. . 2007. Mar 27 |
abstract |
| CKS1B, over expressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and independent mechanisms. |
Zhan F, et al.
Blood. 2007. Feb 15. |
abstract |
| VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo |
Siner JM, et al.
FASEB J. 2007. Jan 30. |
abstract |
| Regulating MHC expression for cellular therapeutics. |
Figueiredo C, et al.
Transfusion. 2007. Jan; 47(1):18-27. |
abstract |
| Identification of cell-type-specific promoters within the brain using lentiviral vectors. |
Chhatwal JP, et al.
Gene Ther. 2007. Jan 18. |
abstract |
| Lentiviral and Murine Retroviral Transduction of T Cells for Expression of Human CD40 Ligand. |
Simon, C. Barry, J. Seppen, N. Ramesh, J.L. Foster, K. Seyama, H.D. Ochs, J.V. Garcia, W.R.A. Osborne
Human Gene Therapy. 2000. Jan; 11; (2): 323-332. |
abstract |
| Lentiviral manipulation of gene expression in human adult and embryonic stem cells. |
Clements MO, Godfrey A, Crossley J, Wilson SJ, Takeuchi Y, Boshoff C.
Tissue Eng. 2006. Jul; 12; (7): 1741-51. |
abstract |
| RNA interference pinpoints regulators of cell size and the cell cycle. |
Cully MJ, Leevers SJ
Genome Biol. 2006. 7(5): 219. Epub 2006 May 30. Review |
abstract |
| Building mammalian signalling pathways with RNAi screens. |
Moffat J, Sabatini DM.
Nat Rev Mol. Cell. Biol.. 2006 Mar;7(3):177-87. Review. |
abstract |
| Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. |
Hamaguchi I, et al.
J. Virology. (2000) Vol.74 pp.10778-10784. |
abstract |
| Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. |
Song Y, et al.
Dev. Dyn.. 2006 Apr 20;235(5):1347-1357 |
abstract |
| Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro. |
Yang ZG., Chen Z., Ni Q., Xu N., Shao JB., Yao HP.
World J Gastroenterol. 2005 Jan 28;11(4):498-502 |
abstract |
| Inhibition of hepatitis B virus gene expression by single and dual small interfering RNA treatment. |
Wu KL, Zhang X., Zhang J., Yang Y., Mu YX, Liu M., Lu L., Li, Y., Zhu Y., Wu J.
Virus Res. 2005 Sep;112(1-2):100-7 |
abstract |
| Application of RNA interference to study stem cell function: current status and future perspectives. |
Zou GM, Yoder MC.
Biol Cell. 2005 Mar;97(3):211-9 |
abstract |
| Exploiting the RNA interference pathway to counter hepatitis B virus replication. |
Arbuthnot P., Carmona S., Ely A.
Liver Int. 2005 Feb;25(1):9-15 |
abstract |
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| Assay Design |
| Title |
Author / Journal |
Abstract |
| Mammalian RNAi: a practical guide. |
Sandy P, Ventura A, Jacks T.
Biotechniques. 2005 Aug;39(2):215-24 |
abstract |
| RNAi: the nuts and bolts of the RISC machine. |
Filipowicz W.
Cell. 2005 Jul 15;122(1):17-20 |
abstract |
| The best control for the specificity of RNAi. |
Sarov M, Stewart AF.
Trends Biotechnol. 2005 Sep;23(9):446-8 |
abstract |
| Detection of foreign RNA: implications for RNAi. |
de Veer MJ, Sledz CA, Williams BR.
Immunol Cell Biol. 2005 Jun;83(3):224-8 |
abstract |
| Defining and assaying RNAi in mammalian cells. |
Huppi K, Martin SE, Caplen NJ.
Mol. Cell. 2005 Jan 7;17(1):1-10 |
abstract |
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| Reviews |
| Title |
Author / Journal |
Abstract |
| Role of RNA interference in plant improvement. |
Jagtap U.B., et al.
Naturwissenschaften. 2011 Apr 19. [Epub ahead of print] |
abstract |
| RNAi-based therapeutic strategies for metabolic disease. |
Czech M.P., et al.
Nat. Rev. Endocrinol. 2011 Apr 19. [Epub ahead of print] |
abstract |
| Current prospects for RNA interference-based therapies. |
Davidson B.L., et al.
Nat Rev Genet. 2011 May;12(5):329-40. |
abstract |
| Getting RNAi therapies to the brain. |
Flintoft L.
Nat. Rev. Genet. 2011 May;12(5):296. |
abstract |
| Strategies for silencing human disease using RNA interference. |
Kim DH, et al.
Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review. |
abstract |
| RNA interference technologies and their use in Cancer Res.earch. |
Gaither A, Iourgenko V.
Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review. |
abstract |
| Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi. |
Snove O Jr, Rossi JJ.
Genome Biol. 2006; 7(8): 231. Review. |
abstract |
| RNA interference in mice. |
Kuhn R, Streif S, Wurst W.
Handb Exp Pharmacol. 2007; 178: 149-76. Review. |
abstract |
| RNA interference: natural, experimental, and clinical roles in cancer biology. |
Mroz EA, Rocco JW.
Head Neck. 2006; Dec; 28(12): 1132-41. Review. |
abstract |
| Gene Silencing by Small Regulatory RNAs in Mammalian Cells. |
Scherr M, Eder M.
Cell Cycle. 2007; Feb 5; 6(4). |
abstract |
| RNA Interference: A New Approach to In Vivo Study of Gene Function. |
Anthony RV, Cantlon JD.
J Anim Sci. 2006. Oct; 13; [Epub ahead of print]. |
abstract |
| RNAi therapy for neurodegenerative diseases. |
Boudreau RL, Davidson BL
Curr Top Dev Biol. 2006. 75: 73-92. Review. |
abstract |
| RNA interference: a potential revolution in disease therapy. |
Waseem T.
J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review. |
abstract |
| RNA interference and potential applications |
Zhou D, He QS, Wang C, Zhang J, Wong-Staal F.
Curr Top Med Chem. 2006; 6(9): 901-11. Review |
abstract |
| The RNA interference revolution |
Lenz G.
Braz J Med Biol Res. 2005 Dec; 38(12): 1749-57. Epub 2005 Nov 9. Review |
abstract |
| Biology calls the targets: combining RNAi and disease biology. |
van Es HH, Arts GJ.
Drug Discov Today. 2005 Oct 15;10(20):1385-91 |
abstract |
| RNA interference in neuroscience: progress and challenges. |
Miller VM, Paulson HL, Gonzalez-Alegre P.
Cell Mol Neurobiol. 2005 Dec;25(8):1195-207. Review. |
abstract |
| RNA interference & inhibition of viruses. |
Gadkari DA.
Indian J Med Res. 2005 Mar;121(3):147-50 |
abstract |
| RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. |
Fitzgerald K.
Curr Opin Drug Discov Devel. 2005 Sep;8(5):557-66 |
abstract |
| A Place for RNAi. |
Anderson P.
Dev Cell. 2005 Sep;9(3):311-2 |
abstract |
| Mammalian RNAi: a practical guide. |
Sandy P, Ventura A, Jacks T.
Biotechniques. 2005 Aug;39(2):215-24 |
abstract |
| Current efforts in the analysis of RNAi and RNAi target genes. |
Bengert P, Dandekar T.
Brief Bioinform. 2005 Mar;6(1):72-85 |
abstract |
| The ins and outs of RNAi in mammalian cells. |
Banan M, Puri N.
Curr Pharm Biotechnol. 2004 Oct;5(5):441-50 |
abstract |
| Approaches for chemically synthesized siRNA and vector-mediated RNAi. |
Amarzguioui M, Rossi JJ KD.
FEBS Lett. 2005 Oct 31;579(26):5974-81 |
abstract |
| back to top |
| High Titer |
| Title |
Author / Journal |
Abstract |
| On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate. |
Seth P., et al.
Neoplasia. Jan;13(1):60-71. |
abstract |
| Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. |
Pavri R., et al.
Cell. 2010 Oct 1;143(1):122-33. |
abstract |
| Creating Higher Titer Lentivirus with Caffeine. |
Ellis B., et al.
Hum. Gene Ther. 2011 Jan;22(1):93-100. Epub 2010 Dec 12. |
abstract |
| back to top |
| Screening |
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Author / Journal |
Abstract |
 Disease-Association Analysis of an Inflammation-Related Feedback Loop.
|
Murakami, M., et al.
Cell Reports. 2013 Mar 28;3(3):946–959.
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abstract |
| Functional identification of optimized RNAi triggers using a massively parallel sensor assay. |
Fellmann C., et al.
Mol. Cell.. 2011 Mar 18;41(6):733-46. Epub 2011 Feb 25. |
abstract |
| Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection. |
Pan Q., et al.
FEBS Lett. 2011 Apr 6;585(7):1025-30. Epub 2011 Mar 2. |
abstract |
| back to top |
| General RNAi |
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Author / Journal |
Abstract |
| Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. |
Lister A., et al.
Mol. Cancer. 2011 Apr 13;10(1):37. [Epub ahead of print] |
abstract |
| back to top |
| RNAi in Neurons |
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Author / Journal |
Abstract |
| Opposing Roles of PlexinA and PlexinB in Axonal Branch and Varicosity Formation. |
Neufeld S.Q., et al.
Mol Brain. 2011 Apr 13;4(1):15. [Epub ahead of print] |
abstract |
| back to top |
| RNAi in Yeast and Overview of RNAi Machinery |
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Author / Journal |
Abstract |
| Reconstitution of human RNA interference in budding yeast. |
Sulk K., et al.
Nucleic Acids Res. 2011 Apr 1;39(7):e43. Epub 2011 Jan 19. |
abstract |
| back to top |
| In Vivo siRNA |
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Author / Journal |
Abstract |
| Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. |
Alvarez-Erviti L., et al.
Nat. Biotechnol. 2011 Apr;29(4):341-5. Epub 2011 Mar 20. |
abstract |
| shRNA Transduction of Human Primary T Cells |
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Author / Journal |
Abstract |
RNA Interference Screen in Primary Human T Cells Reveals FLT3 as a Modulator of IL-10 Levels
|
Astier A.L., et al.
The Journal of Immunology. 2010 Jan;184(2):685-93. Epub 2009 Dec 16. |
abstract |
APOBEC3G-Depleted Resting CD4+ T Cells Remain Refractory to HIV1 Infection
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Santoni de Sio F.R., et al.
PLoS ONE. 2009 Aug;4(8):e6571.
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abstract |
Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors
|
An D.S., et al.
Molecular Therapy. 2006 Oct;14(4):494–504. Epub 2006 Jul 17.
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abstract |
| Pooled shRNA Screening and Deconvolution |
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Author / Journal |
Abstract |
RNAi screens in mice identify physiological regulators of oncogenic growth
|
Beronja S., et al.
Nature. 2013 Aug 14. doi: 10.1038/nature12464. [Epub ahead of print] |
abstract |
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK
|
Lin Y.Y., et al.
Nature. 2012 Feb;482(7384):251–5.
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abstract |
A primer on using pooled shRNA libraries for functional genomic screens
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Hu G., et al.
Acta Biochim Biophys Sin. 2012 Feb;44(2):103–12.
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abstract |
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
|
Possemato R., et al.
Nature. 2011 Aug;476(7360):346-50.
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abstract |
| Forward RNAi screens in human stem cells. |
Karlsson, C., et al.
Methods Mol. Biol. 2010; 650: 29-43. |
abstract |
