Looking for current application references in the field of RNAi?
Look no further.
Listed below are many of the top research articles relevant to RNAi and Functional Genomics research. Articles include shRNA, lentiviral-based systems, delivery to various cell lines and transgenic animals, as well as reviews on siRNA. All references are linked to PubMed, where you can find complete abstract information and relevant journal information.
If you would like a particular reference added to the current bibliography, please email us at biotechsolutions@sial.com. If we are able, we will add it to the list.
| Basic Mechanism | ||
| Title | Author / Journal | Abstract |
| Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown. | Moore C.B., et al. Methods. Mol. Biol. 2010;629:141-58. |
abstract |
| The RNA silencing technology applied by lentiviral vectors in oncology. | Sumimoto H., et al. Methods Mol. Biol. 2010;614:187-99. |
abstract |
| Gene silencing by small regulatory RNAs in mammalian cells. | Scherr M., et al. Cell Cycle. 2007 Feb 15;6(4):444-9. Epub 2007 Feb 5. Review. |
abstract |
| The silent treatment: RNAi as a defense against virus infection in mammals. | van Rij RP, Andino R. Trends Biotechnol. 2006. Apr;24(4):186-93. Epub 2006. Feb 28. |
abstract |
| A Facile Lentiviral Vector System for Expression of Doxycycline-Inducible shRNAs: Knockdown of the Pre-miRNA Processing Enzyme Drosha. | Aagaard L, et al. Mol Ther. 2007. Feb 20. |
abstract |
| RNA interference has a role in regulating Drosophila telomeres. | Casacuberta E, Pardue ML. Perrimon. Genome Biol. 2006. 7(5):220. Epub 2006 May 31. Review. |
abstract |
| Is RNA interference involved in intrinsic antiviral immunity in mammals? | Cullen BR. Nat. Immunol. 2006. June; 7(6):563-7. Review. |
abstract |
| Gene silencing of virus replication by RNA interference. | Miyano-Kurosaki N, Takaku H. Handb Exp Pharmacol. 2006;(173):151-71. |
abstract |
| Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? | Jaronczyk K, Carmichael JB, Hobman TC. Biochem. J.. 2005 May 1;387(Pt 3):561-71. |
abstract |
| Viral delivery of recombinant short hairpin RNAs. | Davidson BL, Harper SQ. Methods Enzymol. 2005;392:145-73 |
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| Paradigms for conditional expression of RNA interference molecules for use against viral targets. | Strayer DS, Feitelson M., Sun B., Matskevich AA. Methods Enzymol. 2005;392:227-41 |
abstract |
| Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation. | Hutvagner G. FEBS Lett. 2005 Oct 31;579(26):5850-7 |
abstract |
| Uncovering RNAi mechanisms in plants: biochemistry enters the foray. | Qi Y, Hannon GJ. FEBS Lett. 2005 Oct 31;579(26):5899-903 |
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| Plant pathology and RNAi: a brief history. | Lindbo JA, Dougherty WG. Annu Rev Phytopathol. 2005;43:191-204 |
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| RNAi: the nuts and bolts of the RISC machine. | Filipowicz W. Cell. 2005 Jul 15;122(1):17-20 |
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| Molecular mechanisms of RNAi: implications for development and disease. | Rao M, Sockanathan S. Birth Defects Res C Embryo Today. 2005 Mar;75(1):28-42 |
abstract |
| RNAi-mediated pathways in the nucleus. | Matzke MA, Birchler JA. Nat Rev Genet. 2005 Jan;6(1):24-35 |
abstract |
| Dicing and slicing: the core machinery of the RNA interference pathway. | Hammond SM. FEBS Lett. 2005 Oct 31;579(26):5822-9 |
abstract |
| RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences. | Robert VJ, Vastenhouw NL, Plasterk RH. Cold Spring Harb Symp Quant Biol. 2004;69:397-402 |
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| High-Throughput Screening | ||
| Title | Author / Journal | Abstract |
| A comparison of multiple shRNA expression methods for combinatorial RNAi. | McIntyre G.J., et al. Genet Vaccines Ther. 2011 Apr 17;9(1):9. [Epub ahead of print] |
abstract |
| A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments. | Seyhan A.A., et al. Mol. Biosyst. 2011 Apr 12. [Epub ahead of print] |
abstract |
| An RNAi screen identifies USP2 as a factor required for TNF-a induced NF-?B signaling. | Metzig M., et al. Int. J. Cancer. 2011 Apr 7. doi: 10.1002/ijc.26124. [Epub ahead of print] |
abstract |
| Second-Generation Sequencing Supply an Effective Way to Screen RNAi Targets in Large Scale for Potential Application in Pest Insect Control. | Wang Y., et al. PLoS One. 2011 Apr 11;6(4):e18644. |
abstract |
| RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity. | Gilot D., et al. PLoS One. 011 Mar 29;6(3):e18261. |
abstract |
| Large scale RNAi screen reveals that the Inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation. | Wu N., et al. J. Biol. Chem.. 2011 Apr 10. [Epub ahead of print] |
abstract |
| A genome-wide shRNA screen for new OxPhos related genes. | Bayona-Bafaluy M.P., et al. Mitochondrion. 2011 May;11(3):467-75. Epub 2011 Feb 1. |
abstract |
| Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation. | Fan C., et al. Leuk. Lymphoma. Mar;52(3):502-14. Epub 2011 Feb 1. |
abstract |
| RNAi-based functional pharmacogenomics. | Tuzmen S., et al. Methods Mol. Biol. 2011;700:271-90. |
abstract |
| Vigilance and validation: Keys to success in RNAi screening. | Sigoillot F.D., et al. ACS Chem. Biol. 2011 Jan 21;6(1):47-60. Epub 2010 Dec 28. Review. |
abstract |
| Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation. | Bowles R., et al. J. Immunol. Methods. 2010 Dec 15;363(1):21-8. Epub 2010 Sep 24. |
abstract |
| An effective method for controlling false discovery and false nondiscovery rates in genome-scale RNAi screens. J Biomol Screen. | Zhang X.D. Pub. 2010 Oct;15(9):1116-22. Epub 2010 Sep 20. |
abstract |
| High-throughput RNAi screening for N-glycosylation dependent loci in Caenorhabditis elegans. | Struwe W.B., et al. Methods Enzymol. 2010;480:477-93. Review. |
abstract |
| RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells. | Arora S., et al. Gynecol. Oncol. 2010 Sep;118(3):220-7. |
abstract |
| RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma. | Arora S., et al. Mol. Cancer. 2010 Aug 18;9:218. |
abstract |
| Discovery of novel cell proliferation-enhancing gene by random siRNA library based combinatorial screening. | Xiong X., et al. Comb. Chem. High Throughput Screen. 2010 Nov 1;13(9):798-806. |
abstract |
| Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. | Duan Z., et al. Cancer Lett. 2010 Jul 28;293(2):220-9. Epub 2010 Feb 9. |
abstract |
| Identification of inhibitors of HSF1 functional activity by high-content target-based screening. | Au Q., et al. J. Biomol. Screen. 2009 Dec;14(10):1165-75. |
abstract |
| Illuminating the host - how RNAi screens shed light on host-pathogen interactions. | Prudêncio M., et al. Biotechnol J. 2009 Jun;4(6):826-37. Review. |
abstract |
| Integrative analysis of genome-wide RNA interference screens. | Berndt J.D., et al. Sci. Signal. 2009 May 12;2(70):pt4. |
abstract |
| Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. | Ganesan A.K., et al. PLoS Genet. 2008 Dec;4(12):e1000298. Epub 2008 Dec 5. |
abstract |
| Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion. | Huang X., et al. BMC Syst Biol. 2008 Jun 13;2:49. |
abstract |
| From sequence to function: using RNAi to elucidate mechanisms of human disease. | Author, et al. Cell Death Differ. 2008 May;15(5):809-19. Epub 2008 Jan 18. |
abstract |
| An efficient and fully automated high-throughput transfection method for genome-scale siRNA screens. | Chung N., et al. J. Biomol. Screen. 2008 Feb;13(2):142-8. Epub 2008 Jan 23. |
abstract |
| Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. | Perrimon N, Friedman A, Mathey-Prevot B, Eggert US. Drug Discov Today. 2007 Jan;12(1-2):28-33. Epub 2006 Oct 30 |
abstract |
| MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. | Lage H. Curr Drug Targets. 2006. Jul; 7(7):813-21. Review. |
abstract |
| High-throughput RNAi Screening in Cultured Cells: A User's Guide. | Echeverri, C. and N. Perrimon. Nature Reviews Genetics. 2006. 7, 373-384. |
abstract |
| From genome to phenome--RNAi library screening and hit characterization using signaling pathway analysis. | Chatterjee-Kishore M. Curr Opin Drug Discov Devel. 2006 Mar;9(2):231-9. |
abstract |
| High-throughput RNA interference in functional genomics | Janitz M, Vanhecke D, Lehrach H. Handb Exp Pharmacol. 2006;(173):97-104. |
abstract |
| Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation. | Chatterjee-Kishore M, Miller CP. Drug Discov Today. 2005 Nov 15;10(22):1559-65 |
abstract |
| Genome-wide application of RNAi to the discovery of potential drug targets. | Ito M, Kawano K, Miyagishi M, Taira K. FEBS Lett. 2005 Oct 31;579(26):5988-95 |
abstract |
| Genome-wide screening for gene function using RNAi in mammalian cells. | Cullen LM, Arndt GM. Immunol Cell Biol. 2005 Jun;83(3):217-23 |
abstract |
| RNAi and HTS: exploring cancer by systematic loss-of-function. | Willingham AT, Deveraux QL, Hampton GM, Aza-Blanc P. Oncogene. 2004 Nov 1;23(51):8392-400 |
abstract |
| Oncology studies using siRNA libraries: the dawn of RNAi-based genomics. | Sachse C, Echeverri CJ. Oncogene. 2004 Nov 1;23(51):8384-91 |
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| IPTG Inducible shRNA | ||
| Title | Author / Journal | Abstract |
| FOXO3a Is A Major Target Of Inactivation By PI3K/AKT Signaling In Aggressive Neuroblastoma | Santo, E.E., et al. Cancer Res. 2013 Feb 1. [Epub ahead of print] |
abstract |
| Shifting the Paradigm: The Putative Mitochondrial Protein ABCB6 Resides in the Lysosomes of Cells and in the Plasma Membrane of Erythrocytes |
Kiss, K., et al. PLoS One. 2012; 7(5) |
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| In Vivo Applications | ||
| Title | Author / Journal | Abstract |
| Knock-down of gene expression in hematopoietic cells. | Scherr M., et al. Methods Mol Biol. 2009;506:207-19. |
abstract |
| Reversible suppression of an essential gene in adult mice using transgenic RNA interference. | McJunkin K., et al. Proc. Natl. Acad. Sci. USA. 2011 Apr 11. [Epub ahead of print] |
abstract |
| Asymmetric cell divisions promote Notch-dependent epidermal differentiation. | Williams, S.E., et al. Nature. 2011 Feb 17; 470 (7334): 353-358. | abstract |
| Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. | Beronja, S., et al. Nat Med. 2010 Jul; 16(7):821-827. | abstract video |
| Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis. | Azmi, A.S., et al. Mol Cancer Ther. 2008 Sep;7(9):2884-93. |
abstract |
| Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles. | Bartlett, D.W., et al. Biotechnol Bioeng. 2008 Mar 1;99(4):975-85. |
abstract |
| A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to Experimental Colitis. | Boirivant, M., et al. Gastroenterology. 2008 Aug 5. [Epub ahead of print] |
abstract |
| Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention. | Chiu, C.C., et al. Mol Cancer Ther. 2008 Sep;7(9):2788-97. |
abstract |
| Tumor necrosis factor alpha small interfering RNA decreases herpes simplex virus-induced inflammation in a mouse model. | Choi, B., et al. J Dermatol Sci. 2008 Nov;52(2):87-97. Epub 2008 Jun 27. |
abstract |
| Delivery vehicles for small interfering RNA in vivo. | de Fougerolles, A.R. Hum Gene Ther. 2008 Feb;19(2):125-32. |
abstract |
| Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in vitro and Rapidly Growing Tumors in vivo. | Guo, A.M., et al. J Pharmacol Exp Ther. 2008 Jun 30. [Epub ahead of print] |
abstract |
| Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. | Hickerson, R.P., et al. J Invest Dermatol. 2008 Mar;128(3):594-605. Epub 2007 Oct 11. |
abstract |
| A small interfering RNA targeting proteinase-activated receptor-2 is effective in suppression of tumor growth in a Panc1 xenograft model. | Iwanki, K., et al. Int J Cancer. 2008 Feb 1;122(3):658-63. |
abstract |
| Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF. | Jiang, J., et al. J Cell Physiol. 2008 Sep 2. [Epub ahead of print] |
abstract |
| Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer. | Kawata, E., et al. Mol Cancer Ther. 2008 Sep;7(9):2904-12. |
abstract |
| Silencing HIV-1 In Vivo. | Kirchhoff, F. Cell. 2008 Aug 22;134(4):566-8. |
abstract |
| Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. | Kleinman, M.E., et al. Nature. 452, 591-7 (2008). |
abstract |
| Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma. | Jiang, L., et al. Int J Cancer. Oct 2008; 123(8): 1779-86. |
abstract |
| Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy. | Luo, G.H., et al. Transplant Proc. 2008 Sep;40(7):2365-9. |
abstract |
| Misinterpreting the therapeutic effects of siRNA caused by immune stimulation. | Robbins, M., et al. Hum Gene Ther. Aug 19. [Epub ahead of print] (2008). |
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| A dominant role of GTRAP3-18 in neuronal glutathione synthesis. | Watabe, M., et al. J Neurosci. 2008 Sep 17;28(38):9404-13. |
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| Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration. | Yang, Z., et al. N Engl J Med. Aug 27. [Epub ahead of print] (2008). |
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| Down-regulation of beta1-adrenoceptors gene expression by short interfering RNA impairs the memory retrieval in the basolateral amygdala of rats. | Fu, A.L., et al. Neurosci Lett. 2007 Nov 27;428(2-3):77-81. Epub 2007 Sep 26. |
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| In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery. | Golzio, M., et al. Gene Ther. 2007 May;14(9):752-9. Epub 2007 Mar 8. |
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| Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA. | Inoue, T., et al. J Gene Med. 2007 Nov;9(11):994-1001. |
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| Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I. | Kim, S.I., et al. Mol Ther. 2007 Jun;15(6):1145-52. Epub 2007 Apr 17. |
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| Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. | Lasek, A.W., et al. Genes Brain Behav. 2007. Mar 26. |
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| Therapeutic RNA interference of malignant melanoma by electrotransfer of small interfering RNA targeting Mitf. | Nakai, N., et al. Gene Ther. 2007 Feb;14(4):357-65. Epub 2006 Oct 5. |
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| Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. | Pirollo, K.F., et al. Cancer Res. 2007 Apr 1;67(7):2938-43. |
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| Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. | Rozema, D.B., et al. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12982-7. Epub 2007 Jul 24. |
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| A high throughput in vivo model for testing delivery and antiviral effects of siRNAs in vertebrates. | Schyth, B.D., et al. Mol Ther. 2007 Jul;15(7):1366-72. Epub 2007 May 1. |
abstract |
| RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. | Segura, T., et al. J Surg Res. 2007 Aug;141(2):162-70. Epub 2007 Jun 11. |
abstract |
| Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. | Shaw, A.T., et al. Genes Dev. 2007. Mar 15;21(6):694-707. |
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| Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome. | Watanabe, T., et al. J Hepatol. 2007 Dec;47(6):744-50. Epub 2007 Jul 26. |
abstract |
| Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C. | Yogota, T., et al. Biochem Biophys Res Commun. 2007 Sep 21;361(2):294-300. Epub 2007 Jul 16. |
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| Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs. | Aigner, A. J Biotechnology. 2006. Jun 25; 124(1): 12-25. |
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| Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. | Bartlett, D.W., et al. Nucleic Acids Res. 2006 Jan 12;34(1):322-33. Print 2006. |
abstract |
| A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)(HXB2) Rev/Env or codon-optimized HIV-1(JR-FL) gp120 generates durable immune responses in mice. | Buffa. V., et al. J Gen Virol. 2006 Jun;87(Pt 6):1625-34. |
abstract |
| In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency. | Carbonaro, D.A., et al. Mol Ther. 2006 Apr 29; [Epub ahead of print] |
abstract |
| RNA interference in cancer. | Gartel, A.L., et al. Biomol Eng. 2006 Mar;23(1):17-34. Epub 2006 Feb 8. |
abstract |
| RNA interference: a potential therapeutic tool for silencing splice isoforms linked to human diseases. | Gaur, R.K. Biotechniques. 2006 Apr;Suppl:15-22. Review. |
abstract |
| Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. | Guo, W., et al. J Neurosci. 2006 Jan 4;26(1):126-37. |
abstract |
| RNA interference: its use as antiviral therapy. | Haasnoot, J., et al. Handb Exp Pharmacol. 2006;(173):117-50. |
abstract |
| RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. | Howard, K.A., et al. Mol Ther. 2006 Oct;14(4):476-84. Epub 2006 Jul 10. |
abstract |
| Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). | Jha, P., et al. J Immunol. 2006 Jun 15;176(12):7221-31. |
abstract |
| A single siRNA suppresses fatal encephalitis induced by two different flaviviruses. | Kumar, P., et al. PLoS Med. 2006 Apr;3(4):e96. Epub 2006 Feb 14. |
abstract |
| Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. | McNamara, J.O., 2nd, et al. Nat Biotechnol. 2006 Aug;24(8):1005-15. Epub 2006 Jun 25. |
abstract |
| RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. | Modlinger, P., et al. Hypertension. 2006 Feb;47(2):238-44. Epub 2006 Jan 3. |
abstract |
| Antiviral applications of RNAi. | Morris K.V., and Rossi J.J. Curr Opin Mol Ther. 2006 Apr; 8(2):115-21. Review. |
abstract |
| Antiviral applications of RNAi. | Morris K.V., and Rossi J.J. Handb Exp Pharmacol. 2006;(173):105-16 |
abstract |
| Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF). | Murata, M., et al. Curr Eye Res. 2006 Feb;31(2):171-80. |
abstract |
| An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. | Palliser, D., et al. Nature. 2006 Jan 5;439(7072):89-94. Epub 2005 Nov 23. |
abstract |
| RNA interference-mediated prevention and therapy for hepatocellular carcinoma. | Romano, P.R., et al. Oncogene. 2006. Jun 26; 25(27): 3857-65. Review. |
abstract |
| Therapeutic potential of RNAi in metabolic diseases. | Rondinone, C.M. Biotechniques. 2006 Apr; Suppl:31-6. Review. |
abstract |
| RNAi as a treatment for HIV-1 infection. | Rossi, J.J. Biotechniques. 2006 Apr; Suppl:25-9. Review. |
abstract |
| A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. | Santel, A., et al. Gene Ther. 2006 Aug;13(16):1222-34. Epub 2006 Apr 20. |
abstract |
| Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma. | Toub, N., et al. Pharm Res. 2006 May;23(5):892-900. Epub 2006 May 2. |
abstract |
| In Vivo Gene Transfer into Adult Stem Cells in Unconditioned Mice by in Situ Delivery of a Lentiviral Vector. | Worsham, D.N., et al. Mol Ther. 2006. 14: 514-24. |
abstract |
| RNAi-mediated gene silencing in non-human primates. | Zimmermann, T.S., et al. Nature. 2006 May 4;441(7089):111-4. Epub 2006 Mar 26. |
abstract |
| RNAi-induced gene silencing by local electroporation in targeting brain region. | Akaneya, Y., et al. J Neurophysiol. 2005 Jan;93(1):594-602. |
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| RNAi as an antiviral therapy. | Bagasra, O. Expert Opin Biol Ther. 2005 Nov;5(11):1463-74. Review. |
abstract |
| Use of RNA interference to prevent lethal murine west nile virus infection. | Bai, F., et al. J Infect Dis. 2005 Apr 1;191(7):1148-54. Epub 2005 Feb 23. |
abstract |
| Inhibition of respiratory viruses by nasally administered siRNA. | Bitko, V., et al. Nat Med. 2005 Jan;11(1):50-5. Epub 2004 Dec 26. |
abstract |
| State-of-the-art modified RNAi compounds for therapeutics. | Carstea, E.D., et al. IDrugs. 2005 Aug;8(8):642-7. |
abstract |
| Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo. | Chein, P.Y., et al. Cancer Gene Ther. 2005 Mar;12(3):321-8. |
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| Silencing viruses by RNA interference. | Colboere-Garapin, F., et al. Microbes Infect. 2005 Apr;7(4):767-75. |
abstract |
| Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. | Filleur, S., et al. Cancer Res. 2005 Jun 15;65(12):5144-52. |
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| Delivering RNA interference to the mammalian brain. | Fountaine, T.M., et al. Curr Gene Ther. 2005 Aug;5(4):399-410. |
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| RNA interference & inhibition of viruses. | Gadkari, D.A. Indian J Med Res. 2005 Mar;121(3):147-50. |
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| A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. | Guan, H., et al. Clin Cancer Res. 2005 Apr 1;11(7):2662-9. |
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| Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney. | Hassan, A., et al. Physiol Genomics. 2005 May 11;21(3):382-8. Epub 2005 Mar 22. |
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| RNA interference for treating haematological malignancies. | Hexner, E.O., and Gewirtz, A.M. Expert Opin Biol Ther. 2005 Dec;5(12):1585-92. Review. |
abstract |
| Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. | Hu-Lieskovan, S., et al. Cancer Research. 2005, 65, 8984-92. |
abstract |
| Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin. | Ito, M., et al. J Gene Med. 2005 Aug;7(8):1044-52. |
abstract |
| Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency. | Kim, T.W., et al. Cancer Res. 2005 Jan 1;65(1):309-16. |
abstract |
| Potential applications of RNA interference technology in the treatment of cancer. | Lage, H. Future Oncol. 2005 Feb;1(1):103-13. Review. |
abstract |
| Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo. | Leng, Q., et al. Cancer Gene Ther. 2005 Aug;12(8):682-90. |
abstract |
| Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. | Li, B.J., et al. Nature Medicine. 2005,9, 944-951. |
abstract |
| Silencing of CXCR4 blocks breast cancer metastasis. | Liang, Z., et al. Cancer Res. 2005 Feb 1;65(3):967-71. |
abstract |
| Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. | Lingor, P., et al. Brain. 2005 Mar;128(Pt 3):550-8. Epub 2005 Jan 19. |
abstract |
| Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury. | Lomas-Neira, J., et al. Cytokine. 2005 Aug 7;31(3):169-79. |
abstract |
| In vivo application of RNA interference: from functional genomics to therapeutics. | Lu, P.Y., et al. Adv Genet. 2005;54:117-42. |
abstract |
| An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. | Luo, M.C., et al. Mol Pain. 2005 Sep 28;1:29. |
abstract |
| In vitro and in vivo suppression of GJB2 expression by RNA interference. | Maeda, Y., et al. Hum Mol Genet. 2005 Jun 15;14(12):1641-50. Epub 2005 Apr 27. |
abstract |
| Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice. | Merl, S., et al. Circulation. 2005 Apr 5;111(13):1583-92. Epub 2005 Mar 28. |
abstract |
| Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors. | Moore, M., et al. J Gene Med. 2005 Jul;7(7):918-25. |
abstract |
| Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. | Morrissey, D.V., et al. Nat Biotechnol. 2005 Aug;23(8):1002-7. Epub 2005 Jul 24. |
abstract |
| Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. | Nogawa, M., et al. J Clin Invest. 2005 Apr;115(4):978-85. Epub 2005 Mar 10. |
abstract |
| Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer. | Ocker, M., et al. Gut. 2005 Sep;54(9):1298-308. |
abstract |
| Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. | Pal, A., et al. Int J Oncol. 2005 Apr;26(4):1087-91. |
abstract |
| Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. | Pillé, J.Y., et al. Mol Ther. 2005 Feb;11(2):267-74. |
abstract |
| Progress toward the therapy of hepatitis with RNAi. | Rendall, G. Hepatology. 2005 Jun;41(6):1220-2. |
abstract |
| Gene silencing in rat-liver and limb grafts by rapid injection of small interference RNA. | Sato, Y., et al. Transplantation. 2005 Jan 27;79(2):240-3. |
abstract |
| Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. | Schiffelers, R.M., et al. Arthritis Rheum. 2005 Apr;52(4):1314-8. |
abstract |
| Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. | Sharma, A., et al. Cancer Res. 2005 Mar 15;65(6):2412-21. |
abstract |
| Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. | Song, E., et al. Nat Biotechnol. 2005 Jun;23(6):709-17. Epub 2005 May 22. |
abstract |
| RNA interference-based gene silencing in mice: the development of a novel therapeutical strategy. | Spänkuch, B., et al. Curr Pharm Des. 2005;11(26):3405-19. |
abstract |
| Exploring RNA interference as a therapeutic strategy for renal disease. | Takabatake, Y., et al. Gene Ther. 2005 Jun;12(12):965-73. |
abstract |
| Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. | Takeshita, F., et al. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12177-82. Epub 2005 Aug 9. |
abstract |
| Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat. | Tan, P.H., et al. Gene Therapy. 2005, 12, 59-66. |
abstract |
| siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain. | Thakker, D.R., et al. Mol Psychiatry. 2005 Aug;10(8):782-9, 714. |
abstract |
| Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. | Uprichard, S., et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):773-8. |
abstract |
| RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. | Urban-Klein, B., et al. Gene Ther. 2005 Mar;12(5):461-6. |
abstract |
| Biology calls the targets: combining RNAi and disease biology. | van Es H.H., and Arts, G.J. Drug Discov Today. 2005 Oct 15;10(20):1385-91. Review. |
abstract |
| Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA. | Wang, Y.L., et al. Neurosci Res. 2005 Nov;53(3):241-9. Epub 2005 Aug 10. |
abstract |
| In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. | Wesche-Soldato, D.E., et al. Blood. 2005 Oct 1;106(7):2295-301. Epub 2005 Jun 7. |
abstract |
| EphB4 expression and biological significance in prostate cancer. | Xia, G., et al. Cancer Res. 2005 Jun 1;65(11):4623-32. |
abstract |
| Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. | Aharinejad, S., et al. Cancer Res. 2004 Aug 1;64(15):5378-84. |
abstract |
| RNA interference as a potential tool in the treatment of leukaemia. | Borkhardt, A., and Heidenreich, O. Expert Opin Biol Ther. 2004 Dec;4(12):1921-9. |
abstract |
| Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. | Chae, S.S., et al. J Clin Invest. 2004 Oct;114(8):1082-9. |
abstract |
| Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. | Contreras, J.L., et al. Surgery. 2004 Aug;136(2):390-400. |
abstract |
| siRNA relieves chronic neuropathic pain. | Dorn, G., et al. Nucleic Acids Res. 2004 Mar 16;32(5):e49. |
abstract |
| EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma. | Duxbury, M.S., et al. Oncogene. 2004 Feb 19;23(7):1448-56. |
abstract |
| Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer. | Duxbury, M.S., et al. Ann Surg. 2004 Oct;240(4):667-74; discussion 675-6. |
abstract |
| Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. | Flynn, M.A., et al. J Inflamm (Lond). 2004 Oct 1;1(1):4. |
abstract |
| Inhibition of influenza virus production in virus-infected mice by RNA interference. | Ge, Q., et al. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8676-81. Epub 2004 Jun 1. |
abstract |
| Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery. | Golzio, M., et al. Gene Therapy. 2004, 12, 246-251. |
abstract |
| A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. | Hagstrom, J.E., et al. Molecular Therapy. 2004, 10, 386-398. |
abstract |
| Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. | Hamar, P., et al. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14883-8. Epub 2004 Oct 4. |
abstract |
| Lack of interferon response in animals to naked siRNAs. | Heidel, J., et al. Nature Biotechnology. 2004, 22, 1579-1582 |
abstract |
| Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. | Kim, B., et al. Am J Pathol. 2004 Dec;165(6):2177-85. |
abstract |
| Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. | Kong, X.C., et al. EMBO Report. 2004, 5, 183-188. |
abstract |
| In vivo activity of nuclease-resistant siRNAs. | Layzer, J.M., et al. RNA. 2004, 10, 766-771. |
abstract |
| Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice. | Massaro, D., et al. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2004, 287, L1066-L1070. |
abstract |
| Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. | Minakuchi, Y., et al. Nucleic Acids Res. 2004 Jul 22;32(13):e109. |
abstract |
| RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. | Nakamura, H., et al. Mol Vis. 2004 Oct 4;10:703-11. |
abstract |
| Challenges for RNAi in vivo. | Paroo, Z., and Corey, D.R. Trends Biotechnol. 2004 Aug;22(8):390-4. |
abstract |
| RNAi knock-down mice: an emerging technology for post-genomic functional genetics. | Prawitt, D., et al. Cytogenet Genome Res. 2004;105(2-4):412-21. |
abstract |
| Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. | Schiffelers, R.M., et al. Nucleic Acids Res. 2004 Nov 1;32(19):e149. |
abstract |
| Systemic delivery of synthetic siRNAs. | Sioud, M., and Sørensen, D.R. Methods Mol Biol. 2004;252:515-22. |
abstract |
| Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. | Soutschek, J., et al. Nature. 2004 Nov 11;432(7014):173-8. |
abstract |
| Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1. | Spänkuch, B., et al. J Natl Cancer Inst. 2004 Jun 2;96(11):862-72. |
abstract |
| A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. | Takei, Y., et al. Cancer Res. 2004 May 15;64(10):3365-70. |
abstract |
| RNAi, a new therapeutic strategy against viral infection. | Tan, F.L., and Yin, J.Q. Cell Res. 2004 Dec;14(6):460-6. |
abstract |
| Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. | Thakker, D.R., et al. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17270-5. Epub 2004 Nov 29. |
abstract |
| Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization. | Tolentino, M.J., et al. Retina. 2004, 24, 132-138. |
abstract |
| Protection against lethal influenza virus challenge by RNA interference in vivo. | Tompkins, S.M., et al. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8682-6. Epub 2004 Jun 1. |
abstract |
| Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer. | Yano, J., et al. Clin Cancer Res. 2004 Nov 15;10(22):7721-6. |
abstract |
| Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. | Zhang, X., et al. J Biol Chem. 2004 Mar 12;279(11):10677-84. Epub 2003 Dec 18. |
abstract |
| RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity. | Duxbury, M.S., et al. Biochem Biophys Res Commun. 2003 Nov 21;311(3):786-92. |
abstract |
| SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. | Filleur, S., et al. Cancer Research. 2003, 63, 3919-3922. |
abstract |
| Small interfering RNA inhibits hepatitis B virus replication in mice. | Giladi, H., et al. Mol Ther. 2003 Nov;8(5):769-76. |
abstract |
| Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. | Klein, C., et al. Gastroenterology. 2003 Jul;125(1):9-18. |
abstract |
| Inhibition of Hepatitis B virus in mice by RNA interference. | McCaffrey, A.P., et al. Nature Biotechnology. 2003, 21, 639-644. |
abstract |
| Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. | Reich, S.J., et al. Mol Vis. 2003 May 30;9:210-6. |
abstract |
| RNA interference targeting Fas protects mice from fulminant hepatitis. | Song, E., et al. Nat Med. 2003 Mar;9(3):347-51. Epub 2003 Feb 10. |
abstract |
| Gene silencing by systemic delivery of synthetic siRNAs in adult mice. | Sørensen, D.R., et al. J Mol Biol. 2003 Apr 4;327(4):761-6. |
abstract |
| Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. | Verma, U.N., et al. Clin Cancer Res. 2003 Apr;9(4):1291-300. |
abstract |
| Caspase 8 small interfering RNA prevents acute liver failure in mice. | Zender, L., et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7797-802. Epub 2003 Jun 16. |
abstract |
| Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis. | Baker-Herman, T.L., et al. J Neurosci. 2002 Jul 15;22(14):6239-46. |
abstract |
| Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo. | Bertrand, J.R., et al. Biochem Biophys Res Commun. 2002 Aug 30;296(4):1000-4. |
abstract |
| Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. | Lewis, D.L., et al. Nat Genet. 2002 Sep;32(1):107-8. Epub 2002 Jul 29. |
abstract |
| Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. | Lewis, D.L., et al. Nature Genetics. 2002, 21, 639-644. |
abstract |
| Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. | Makimura, H., et al. BMC Neurosci. 2002 Nov 7;3:18. |
abstract |
| RNA interference in adult mice. | McCaffrey, A.P., et al. Nature. 2002 Jul 4;418(6893):38-9. |
abstract |
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| In Vivo Disease Treatment | ||
| Title | Author / Journal | Abstract |
| Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. | Possemato R., et al. Nature.. 2011. Aug;476:346-350. |
abstract |
| Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference. | Sang W., et al. Immunol Lett.. 2011. May;136(2):194-202. Epub 2011 Jan 26. |
abstract |
| Therapeutic regulation of gene expression in the inner ear using RNA interference. | Maeda Y., et al. Adv. Otorhinolaryngol.. 2009;66:13-36. Epub 2009 Jun 2. Review. |
abstract |
| Silencing the breast cancer resistance protein expression and function in caco-2 cells using lentiviral vector-based short hairpin RNA. | Zhang W., et al. Drug Metab. Dispos.. 2009 Apr;37(4):737-44. Epub 2009 Jan 8. |
abstract |
| Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication. | Gao Y., et al. J. Virol.. 2008 Mar;82(6):2938-51. Epub 2008 Jan 16. |
abstract |
| RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors. | Schaser T., et al. Gene Ther.. 2011. Apr 7. [Epub ahead of print] |
abstract |
| Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes-CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy-in SCID-hu Mouse-Derived T Cells. | Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. Mol Ther. 2007. Apr 3. |
abstract |
| Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy. | Capowski EE, Schneider BL, Ebert AD, Seehus CR, Szulc J, Zufferey R, Aebischer P, Svendsen CN. J Neurosci Methods. 2007. Mar 3. |
abstract |
| Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors. | Greenberg KP, et al. Invest Ophthalmol Vis Sci. 2007. Apr;48(4):1844-52. |
abstract |
| Target validation using RNA interference in solid tumors. | Aharinejad S, et al. Methods Mol Biol. 2007;361:227-38. Review. |
abstract |
| Gene delivery to airway epithelial cells in vivo: a direct comparison of apical and basolateral transduction strategies using pseudotyped lentivirus vectors. | Kremer KL, et al. J Gene Med. 2007. Mar 22. |
abstract |
| RNAi therapy for neurodegenerative diseases. | Boudreau RL, Davidson BL Curr Top Dev Biol. 2006. 75: 73-92. Review. |
abstract |
| Interference RNA technology in the treatment of CNV. | Tolentino M Ophthalmol Clin North Am. 2006. Sep; 19(3): 393-9, vi-vii. Review. |
abstract |
| RNA interference: a potential revolution in disease therapy. | Waseem T. J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review. |
abstract |
| Correction of Cardiac Abnormalities in Fabry Mice by Direct Intraventricular Injection of a Recombinant Lentiviral Vector that Engineers Expression of alpha-Galactosidase A. | Yoshimitsu M, Higuchi K, Dawood F, Rasaiah VI, Ayach B, Chen M, Liu P, Medin JA. Circ J. 2006. Nov; 70(11): 1503-8. |
abstract |
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| MISSION® siRNA Publications | ||
| Title | Author / Journal | Abstract |
| RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity | Gilot, D. et al. PLoS ONE 2011, 6(3). |
e18261 |
| Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts | Meng, W. et al. Cell 2008 Nov. 28, 135(5), 948-59. |
abstract |
| BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation | Matsubara, T. et al. J. Biol. Chem. 2008 Oct., 283(43), 29119-25. Epub 2008 Aug, 14. |
abstract |
| Genome-Scale RNAi Screen for Host Factors Required for HIV Replication | Zhou, H. et al. Cell Host Microbe 2008 Oct 29. [Epub ahead of print]. |
abstract |
| Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. | Bartz. S.R., et al., Mol Cell Biol. 2006. 26: 9377-86. |
abstract |
| Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. | Chajès, V., et al., Cancer Res. 2006.66: 5287-94. |
abstract |
| A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. | Espeseth, A.S., et al., Mol Cell Neurosci. 2006.33: 227-35. |
abstract |
| Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. | Kim, E.J., et al., J Biol Chem. 2006.281:33250-7. |
abstract |
| Cleavage of the siRNA passenger strand during RISC assembly in human cells. | Leuschner, P.J., et al., EMBO Rep. 2006.7: 314-20. |
abstract |
| A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. | Miserey-Lenkei, S., et al., EMBO J. 2006.25: 278-89. |
abstract |
| BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. | Moreau, K., et al., J Biol Chem. 2006.281: 3172-81. |
abstract |
| Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA. | Poncet, D, et al., J Cell Biol. 2006.174: 985-96. |
abstract |
| RalB mobilizes the exocyst to drive migration. | Rossé, C., et al., Mol Cell Biol. 2006.26: 727-34. |
abstract |
| The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. | Wang, F., et al., Mol Cell Biol. 2006. 26: 4028-40. |
abstract |
| Induction of centrosome amplification during arsenite-induced mitotic arrest in CGL-2 cells. | Yih, L.H., et al., Cancer Res. 2006.66: 2098-106. |
abstract |
| A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages | Colucci-Guyon, E., et al., Curr Biol. 2005.15: 2007-12. |
abstract |
| A vital role of tubulin-tyrosine-ligase for neuronal organization. | Erck, C., et al., Proc Natl Acad Sci U S A. 2005. 102:7853-8. |
abstract |
| Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization. | Etienne-Manneville, S., et al., J Cell Biol. 2005.170: 895-901. |
abstract |
| Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma. | Guida, T., et al., J Clin Endocrinol Metab. 2005.90 (8):4703-9. |
abstract |
| Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. | Johnson. J., et al., RNA. 2005.11: 1737-44. |
abstract |
| Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively. | Porta, C., et al., Oncogene 2005.24: 605-15. |
abstract |
| RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. | Putral, L.N., et al., Mol Pharmacol. 2005.68:1311-9. |
abstract |
| Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. | Shiraishi, T., et al., Cancer Res. 2005.65: 6364-70. |
abstract |
| Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. | Stapelberg, M., et al., J Biol Chem. 2005.280: 25369-76. |
abstract |
| Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA. | Terasaki, T., et al., J Neurochem. 2005. 93: 63-71. |
abstract |
| Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif. | Darnell, G.A., et al., Mol Cell Biol. 2003.23: 6520-32. |
abstract |
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| Specific Applications | ||
| Title | Author / Journal | Abstract |
| Mpz gene suppression by shRNA increases Schwann cell apoptosis in vitro. | Lei L., et al. Neurol Sci.. 2010 Oct;31(5):603-8. Epub 2010 Jun 15. |
abstract |
| A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animals. | Zhang J., et al. RNA. 2007 Aug;13(8):1375-83. Epub 2007 Jul 6. |
abstract |
| Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. | Chen Y., et al. Hepatology. 2007 Jul;46(1):200-8. Erratum in: Hepatology. 2007 Oct;46(4):1314. |
abstract |
| STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo. | Huang C., et al. Int. J. Oncol. 2011 Jun;38(6):1637-44. doi: 10.3892/ijo.2011.1000. Epub 2011 Apr 8. |
abstract |
| Lentiviral-mediated Smad4 RNAi promotes SMMC-7721 cell migration by regulation of MMP-2, VEGF and MAPK signaling. | Huang X., et al. Mol. Med. Report. 2010 Mar-Apr;3(2):295-9. doi: 10.3892/mmr_00000254 |
abstract |
| RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation. | Walsh N., et al. Cancer Lett. 2011 Apr 4. [Epub ahead of print] |
abstract |
| Down-Regulation of TNF-Alpha by Small Interfering RNA Inhibits Particle-Induced Inflammation In Vitro. | Qin C.Q., et al. Artif. Organs. 2011 Apr 19. doi: 10.1111/j.1525-1594.2010.01175.x. [Epub ahead of print] |
abstract |
| Nicotine Induces Pro-inflammatory Response in Aortic Vascular Smooth Muscle Cells Through a NF?B/Osteopontin Amplification Loop-Dependent Pathway. | Wang Y., et al. Inflammation. 2011 Apr 15. [Epub ahead of print] |
abstract |
| beta Cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery. | McCabe C, O'Brien T. Biochem. Biophys. Res. Commun.. 2007 May 25;357(1):75-80. Epub 2007 Mar 28. |
abstract |
| Trophoblast-specific gene manipulation using lentivirus-based vectors. | Georgiades P, et al. Biotechniques. 2007. Mar;42(3):317-8, 320, 322-5. |
abstract |
| Suppression of PPAR{gamma} Attenuates Insulin-Stimulated Glucose Uptake by Affecting Both GLUT1 and GLUT4 in 3T3-L1 Adipocytes. | Liao W, et al. Am J Physiol Endocrinol Metab. . 2007. Mar 27 |
abstract |
| CKS1B, over expressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and independent mechanisms. | Zhan F, et al. Blood. 2007. Feb 15. |
abstract |
| VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo | Siner JM, et al. FASEB J. 2007. Jan 30. |
abstract |
| Regulating MHC expression for cellular therapeutics. | Figueiredo C, et al. Transfusion. 2007. Jan; 47(1):18-27. |
abstract |
| Identification of cell-type-specific promoters within the brain using lentiviral vectors. | Chhatwal JP, et al. Gene Ther. 2007. Jan 18. |
abstract |
| Lentiviral and Murine Retroviral Transduction of T Cells for Expression of Human CD40 Ligand. | Simon, C. Barry, J. Seppen, N. Ramesh, J.L. Foster, K. Seyama, H.D. Ochs, J.V. Garcia, W.R.A. Osborne Human Gene Therapy. 2000. Jan; 11; (2): 323-332. |
abstract |
| Lentiviral manipulation of gene expression in human adult and embryonic stem cells. | Clements MO, Godfrey A, Crossley J, Wilson SJ, Takeuchi Y, Boshoff C. Tissue Eng. 2006. Jul; 12; (7): 1741-51. |
abstract |
| RNA interference pinpoints regulators of cell size and the cell cycle. | Cully MJ, Leevers SJ Genome Biol. 2006. 7(5): 219. Epub 2006 May 30. Review |
abstract |
| Building mammalian signalling pathways with RNAi screens. | Moffat J, Sabatini DM. Nat Rev Mol. Cell. Biol.. 2006 Mar;7(3):177-87. Review. |
abstract |
| Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. | Hamaguchi I, et al. J. Virology. (2000) Vol.74 pp.10778-10784. |
abstract |
| Application of lentivirus-mediated RNAi in studying gene function in mammalian tooth development. | Song Y, et al. Dev. Dyn.. 2006 Apr 20;235(5):1347-1357 |
abstract |
| Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro. | Yang ZG., Chen Z., Ni Q., Xu N., Shao JB., Yao HP. World J Gastroenterol. 2005 Jan 28;11(4):498-502 |
abstract |
| Inhibition of hepatitis B virus gene expression by single and dual small interfering RNA treatment. | Wu KL, Zhang X., Zhang J., Yang Y., Mu YX, Liu M., Lu L., Li, Y., Zhu Y., Wu J. Virus Res. 2005 Sep;112(1-2):100-7 |
abstract |
| Application of RNA interference to study stem cell function: current status and future perspectives. | Zou GM, Yoder MC. Biol Cell. 2005 Mar;97(3):211-9 |
abstract |
| Exploiting the RNA interference pathway to counter hepatitis B virus replication. | Arbuthnot P., Carmona S., Ely A. Liver Int. 2005 Feb;25(1):9-15 |
abstract |
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| Assay Design | ||
| Title | Author / Journal | Abstract |
| Mammalian RNAi: a practical guide. | Sandy P, Ventura A, Jacks T. Biotechniques. 2005 Aug;39(2):215-24 |
abstract |
| RNAi: the nuts and bolts of the RISC machine. | Filipowicz W. Cell. 2005 Jul 15;122(1):17-20 |
abstract |
| The best control for the specificity of RNAi. | Sarov M, Stewart AF. Trends Biotechnol. 2005 Sep;23(9):446-8 |
abstract |
| Detection of foreign RNA: implications for RNAi. | de Veer MJ, Sledz CA, Williams BR. Immunol Cell Biol. 2005 Jun;83(3):224-8 |
abstract |
| Defining and assaying RNAi in mammalian cells. | Huppi K, Martin SE, Caplen NJ. Mol. Cell. 2005 Jan 7;17(1):1-10 |
abstract |
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| Reviews | ||
| Title | Author / Journal | Abstract |
| Role of RNA interference in plant improvement. | Jagtap U.B., et al. Naturwissenschaften. 2011 Apr 19. [Epub ahead of print] |
abstract |
| RNAi-based therapeutic strategies for metabolic disease. | Czech M.P., et al. Nat. Rev. Endocrinol. 2011 Apr 19. [Epub ahead of print] |
abstract |
| Current prospects for RNA interference-based therapies. | Davidson B.L., et al. Nat Rev Genet. 2011 May;12(5):329-40. |
abstract |
| Getting RNAi therapies to the brain. | Flintoft L. Nat. Rev. Genet. 2011 May;12(5):296. |
abstract |
| Strategies for silencing human disease using RNA interference. | Kim DH, et al. Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review. |
abstract |
| RNA interference technologies and their use in Cancer Res.earch. | Gaither A, Iourgenko V. Curr Opin Oncol. 2007. Jan; 19(1): 50-4. Review. |
abstract |
| Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi. | Snove O Jr, Rossi JJ. Genome Biol. 2006; 7(8): 231. Review. |
abstract |
| RNA interference in mice. | Kuhn R, Streif S, Wurst W. Handb Exp Pharmacol. 2007; 178: 149-76. Review. |
abstract |
| RNA interference: natural, experimental, and clinical roles in cancer biology. | Mroz EA, Rocco JW. Head Neck. 2006; Dec; 28(12): 1132-41. Review. |
abstract |
| Gene Silencing by Small Regulatory RNAs in Mammalian Cells. | Scherr M, Eder M. Cell Cycle. 2007; Feb 5; 6(4). |
abstract |
| RNA Interference: A New Approach to In Vivo Study of Gene Function. | Anthony RV, Cantlon JD. J Anim Sci. 2006. Oct; 13; [Epub ahead of print]. |
abstract |
| RNAi therapy for neurodegenerative diseases. | Boudreau RL, Davidson BL Curr Top Dev Biol. 2006. 75: 73-92. Review. |
abstract |
| RNA interference: a potential revolution in disease therapy. | Waseem T. J Coll Physicians Surg Pak. 2006. Jul; 16(7): 491-2. Review. |
abstract |
| RNA interference and potential applications | Zhou D, He QS, Wang C, Zhang J, Wong-Staal F. Curr Top Med Chem. 2006; 6(9): 901-11. Review |
abstract |
| The RNA interference revolution | Lenz G. Braz J Med Biol Res. 2005 Dec; 38(12): 1749-57. Epub 2005 Nov 9. Review |
abstract |
| Biology calls the targets: combining RNAi and disease biology. | van Es HH, Arts GJ. Drug Discov Today. 2005 Oct 15;10(20):1385-91 |
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| RNA interference in neuroscience: progress and challenges. | Miller VM, Paulson HL, Gonzalez-Alegre P. Cell Mol Neurobiol. 2005 Dec;25(8):1195-207. Review. |
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| RNA interference & inhibition of viruses. | Gadkari DA. Indian J Med Res. 2005 Mar;121(3):147-50 |
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| RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. | Fitzgerald K. Curr Opin Drug Discov Devel. 2005 Sep;8(5):557-66 |
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| A Place for RNAi. | Anderson P. Dev Cell. 2005 Sep;9(3):311-2 |
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| Mammalian RNAi: a practical guide. | Sandy P, Ventura A, Jacks T. Biotechniques. 2005 Aug;39(2):215-24 |
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| Current efforts in the analysis of RNAi and RNAi target genes. | Bengert P, Dandekar T. Brief Bioinform. 2005 Mar;6(1):72-85 |
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| The ins and outs of RNAi in mammalian cells. | Banan M, Puri N. Curr Pharm Biotechnol. 2004 Oct;5(5):441-50 |
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| Approaches for chemically synthesized siRNA and vector-mediated RNAi. | Amarzguioui M, Rossi JJ KD. FEBS Lett. 2005 Oct 31;579(26):5974-81 |
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| High Titer | ||
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| On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate. | Seth P., et al. Neoplasia. Jan;13(1):60-71. |
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| Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. | Pavri R., et al. Cell. 2010 Oct 1;143(1):122-33. |
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| Creating Higher Titer Lentivirus with Caffeine. | Ellis B., et al. Hum. Gene Ther. 2011 Jan;22(1):93-100. Epub 2010 Dec 12. |
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| Screening | ||
| Title | Author / Journal | Abstract |
 Disease-Association Analysis of an Inflammation-Related Feedback Loop. |
Murakami, M., et al. Cell Reports. 2013 Mar 28;3(3):946–959. |
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| Functional identification of optimized RNAi triggers using a massively parallel sensor assay. | Fellmann C., et al. Mol. Cell.. 2011 Mar 18;41(6):733-46. Epub 2011 Feb 25. |
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| Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection. | Pan Q., et al. FEBS Lett. 2011 Apr 6;585(7):1025-30. Epub 2011 Mar 2. |
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| General RNAi | ||
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| Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. | Lister A., et al. Mol. Cancer. 2011 Apr 13;10(1):37. [Epub ahead of print] |
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| RNAi in Neurons | ||
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| Opposing Roles of PlexinA and PlexinB in Axonal Branch and Varicosity Formation. | Neufeld S.Q., et al. Mol Brain. 2011 Apr 13;4(1):15. [Epub ahead of print] |
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| RNAi in Yeast and Overview of RNAi Machinery | ||
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| Reconstitution of human RNA interference in budding yeast. | Sulk K., et al. Nucleic Acids Res. 2011 Apr 1;39(7):e43. Epub 2011 Jan 19. |
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| In Vivo siRNA | ||
| Title | Author / Journal | Abstract |
| Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. | Alvarez-Erviti L., et al. Nat. Biotechnol. 2011 Apr;29(4):341-5. Epub 2011 Mar 20. |
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| shRNA Transduction of Human Primary T Cells | ||
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| RNA Interference Screen in Primary Human T Cells Reveals FLT3 as a Modulator of IL-10 Levels |
Astier A.L., et al. The Journal of Immunology. 2010 Jan;184(2):685-93. Epub 2009 Dec 16. |
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| APOBEC3G-Depleted Resting CD4+ T Cells Remain Refractory to HIV1 Infection |
Santoni de Sio F.R., et al. PLoS ONE. 2009 Aug;4(8):e6571. |
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| Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors |
An D.S., et al. Molecular Therapy. 2006 Oct;14(4):494–504. Epub 2006 Jul 17. |
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| Pooled shRNA Screening and Deconvolution | ||
| Title | Author / Journal | Abstract |
| RNAi screens in mice identify physiological regulators of oncogenic growth |
Beronja S., et al. Nature. 2013 Aug 14. doi: 10.1038/nature12464. [Epub ahead of print] |
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| Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK |
Lin Y.Y., et al. Nature. 2012 Feb;482(7384):251–5. |
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| A primer on using pooled shRNA libraries for functional genomic screens |
Hu G., et al. Acta Biochim Biophys Sin. 2012 Feb;44(2):103–12. |
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| Functional genomics reveal that the serine synthesis pathway is essential in breast cancer |
Possemato R., et al. Nature. 2011 Aug;476(7360):346-50. |
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| Forward RNAi screens in human stem cells. | Karlsson, C., et al. Methods Mol. Biol. 2010; 650: 29-43. |
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