Publish Sooner When You Partner with the MISSION® shRNA Team!
The MISSION® TRC1.5 human and mouse shRNA libraries are the proven performers for small-scale to high-throughput RNAi screening. Below you will find a selection of papers where researchers have published in peer-reviewed journals using the TRC1/1.5 library and have cited The Broad Institute or Sigma-Aldrich as their source of high quality reagents. Unlike other shRNA libraries, the clones cited in these publications are the same clones available from Sigma-Aldrich. If a specific clone is not found in our catalog, please inquire at MISSIONRNAi@sial.com for availability.
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How to Cite the TRC Library
In scientific publications, the human library should be referred to as MISSION® TRC-Hs 1.0 (Human) while the mouse library should be referred to as MISSION® TRC-Mm 1.0 (Mouse). If your TRC library was purchased after July 2011, the human library should be referred to as MISSION® TRC-Hs 1.5 (Human) while the mouse library should be referred to as MISSION® TRC-Mm 1.5 (Mouse). If you experimented with our TRC2 library, the human library should be referred to as MISSION® TRC-Hs 2.0 (Human) while the mouse library should be referred to as MISSION® TRC-Mm 2.0 (Mouse).Individual clones should be identified by their unique TRC number (e.g. MISSION® TRC shRNA TRCN0000030720).
| MISSION® shRNA Publications | ||
| Title | Author / Journal | Abstract |
Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma.  |
Lachke, S.A. et al. Science. 2011. 331: 1571-1576 |
abstract |
| Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species. | Sevlever, D. et al. Biochemistry. 2008. 47: 9678-9687 |
abstract |
| EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. | Zhang, Y, et al. Molecular Cancer Therapeutics. 2008.7:3176. |
abstract |
| The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. | Zhang, XY, et al. Mol Cell. 2008.29: 102-11. |
abstract |
| Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. | Zeng, X, et al. Development. 2008.135: 367-75. |
abstract |
| Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. | Yang, WS, et al. Genome Biol. 2008.9: R92. |
abstract |
| Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. | Yamashita, M, et al. J Exp Med. 2008.205: 1109-20. |
abstract |
| Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. | Wimmer-Kleikamp, SH, et al. Blood. 2008.112: 721-32. |
abstract |
| Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells. | Wierzbicki, A, et al. J Immunol. 2008.181: 6644-53. |
abstract |
| Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. | Wei, D, et al. Cancer Res. 2008.68: 4631-9. |
abstract |
| Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1. | Vasilcanu, R, et al. Oncogene. 2008.27: 1629-38. |
abstract |
| Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway. | Varghese, B, et al. Mol Cell Biol. 2008.28: 5275-87. |
abstract |
| Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. | Ueffing, N, et al. Blood. 2008.112: 690-8. |
abstract |
| Inhibition of" self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. | Tsai, R, et al. The Journal of Cell Biology. 2008.180:989. |
abstract |
| Phospholipase D1 is an effector of Rheb in the mTOR pathway. | Sun, Y, et al. Proc Natl Acad Sci U S A. 2008.105: 8286-91. |
abstract |
| The beta1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA+-induced motility of gastric cancer cells. | Snider, JL, et al. J Biol Chem. 2008.283: 13952-63. |
abstract |
| Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages. | Sierra, J, et al. Journal of Experimental Medicine. 2008.205:1673. |
abstract |
| Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. | Shimamura, T, et al. Cancer Res. 2008.68: 5827-38. |
abstract |
| Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2. | Sher, F, et al. Stem Cells. 2008.26:2875. |
abstract |
| The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. | Shema, E, et al. Genes & Development. 2008.22:2664. |
abstract |
| Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms. | Shaikh, FM, et al. Exp Cell Res. 2008.314: 2941-50. |
abstract |
| Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. | Sen, N, et al. Nature Cell Biology. 2008.10:866. |
abstract |
| Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. | Roukens, MG, et al. Mol Cell Biol. 2008.28: 4394-406. |
abstract |
| A Sensitive Flow Cytometry-based Nucleotide Excision Repair Assay Unexpectedly Reveals That Mitogen-activated Protein Kinase Signaling Does Not Regulate the Removal of UV-induced DNA Damage in Human Cells. | Rouget, R, et al. J Biol Chem. 2008.283: 5533-41. |
abstract |
| BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. | Pfister, S, et al. J Clin Invest. 2008.118: 1739-49. |
abstract |
| Identification of Pbx1, a Potential Oncogene, as a Notch3 Target Gene in Ovarian Cancer. | Park, J, et al. Cancer Research. 2008.68:8852. |
abstract |
| TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. | Park, Y, et al. Biochem Biophys Res Commun. 2008.374: 294-8. |
abstract |
| SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. | Nogueira, E, et al. J Biol Chem. 2008.283: 16248-58. |
abstract |
| Genetic Complementation Screen Identifies a Mitogen-activated Protein Kinase Phosphatase, MKP3, as a Regulator of Dopamine Transporter Trafficking. | Mortensen, O, et al. Molecular Biology of the Cell. 2008.19:2818. |
abstract |
| Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. | Martin-Granados, C, et al. Int J Biochem Cell Biol. 2008.40: 2315-32. |
abstract |
| Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation. | Magenta, A, et al. Mol Cell Biol. 2008.28: 873-82. |
abstract |
| Human Cytomegalovirus Protein pp71 Displaces the Chromatin Associated Factor ATRX from Nuclear Domain 10 at Early Stages of Infection. | Lukashchuk, V, et al. Journal of Virology. 2008.epublication ahead of print:. |
abstract |
| Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. | Loo, YM, et al. J Virol. 2008.82: 335-45. |
abstract |
| HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma. | Liau, SS, et al. Clin Cancer Res. 2008.14: 1470-7. |
abstract |
| SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. | Lepagnol-Bestel, AM, et al. Mol Psychiatry. 2008.13: 385-97. |
abstract |
| An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion. | Lamar, JM, et al. Cancer Res. 2008.68: 7371-9. |
abstract |
| VIP and VIP gene silencing modulation of differentiation marker N-cadherin and cell shape of corneal endothelium in human corneas ex vivo. | Koh, SW, et al. Invest Ophthalmol Vis Sci. 2008.49: 3491-8. |
abstract |
| Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. | Kim, JH, et al. J Biol Chem. 2008.283: 708-15. |
abstract |
| DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. | Kappes, F, et al. Mol Cell Biol. 2008.28: 3245-57. |
abstract |
| Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells. | Jong, A, et al. Cellular Microbiology. 2008.epublication ahead of print:. |
abstract |
| Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress. | Jiang, C, et al. Cancer Research. 2008.68:6708. |
abstract |
| Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. | Jiang, CC, et al. Cancer Res. 2008.68: 6708-17. |
abstract |
| Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. | Ji, Z, et al. J Biol Chem. 2008.283: 21920-5. |
abstract |
| Epigenetic silencing of O6-methylguanine-DNA methyltransferase gene in NiS-transformed cells. | Ji, W, et al. Carcinogenesis. 2008.epublication ahead of print:. |
abstract |
| Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. | Janoueix-Lerosey, I, et al. Nature. 2008.455: 967-70. |
abstract |
| STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. | Ishikawa, H, et al. Nature. 2008.455: 674-8. |
abstract |
| Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. | Hoskins, E, et al. Oncogene. 2008.epublication ahead of print:. |
abstract |
| Targeting AKT Signaling Sensitizes Cancer to Cellular Immunotherapy. | Hahnel, P, et al. Cancer Research. 2008.68:3899. |
abstract |
| A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion. | Gu, J, et al. FEBS Journal. 2008.275: 3145-56. |
abstract |
| Deferiprone targets aconitase: implication for Friedreich's ataxia treatment. | Goncalves, S, et al. BMC Neurol. 2008.8:20. |
abstract |
| Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau. | Gendron, TF, et al. Neurosci Lett. 2008.443: 67-71. |
abstract |
| Induction of autophagy during extracellular matrix detachment promotes cell survival. | Fung, C, et al. Mol Biol Cell. 2008.19: 797-806. |
abstract |
| Malignant pleural mesothelioma-targeted CREBBP/EP300 inhibitory protein 1 promoter system for gene therapy and virotherapy. | Fukazawa, T, et al. Cancer Res. 2008.68: 7120-9. |
abstract |
| Matrix metalloproteinase-10 is a critical effector of protein kinase C iota-Par6 alpha-mediated lung cancer. | Frederick, L, et al. Oncogene. 2008.epublication ahead of print:. |
abstract |
| Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells. | Fattah, FJ, et al. Proc Natl Acad Sci U S A. 2008.105: 8703-8. |
abstract |
| Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. | Escriva, M, et al. Mol Cell Biol. 2008.28: 1528-40. |
abstract |
| Interferon regulatory factors are transcriptional regulators of adipogenesis. | Eguchi, J, et al. Cell Metab. 2008.7: 86-94. |
abstract |
| Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. | Duan, Z, et al. Mol Cancer Ther. 2008.7: 2377-85. |
abstract |
| Functional characterization of the atopy-associated gene PHF11. | Clarke, E, et al. J Allergy Clin Immunol. 2008.121: 1148-54 e3. |
abstract |
| Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. | Cheng, G, et al. Journal of Biological Chemistry. 2008.283:14665. |
abstract |
| Widespread microRNA repression by Myc contributes to tumorigenesis. | Chang, TC, et al. Nat Genet. 2008.40: 43-50. |
abstract |
| Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle Stem Cells. | Carlson, ME, et al. Nature. 2008.454: 528-32. |
abstract |
| The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors. | Caramel, J, et al. Oncogene. 2008.27: 2035-44. |
abstract |
| RhoA-dependent regulation of cell migration by the tumor suppressor hSNF5/INI1. | Caramel, J, et al. Cancer Res. 2008.68: 6154-61. |
abstract |
| E1a gene expression blocks the ERK1/2 signaling pathway by promoting nuclear localization and MKP up-regulation: implication in v-H-Ras-induced senescence. | Callejas-Valera, JL, et al. J Biol Chem. 2008.283: 13450-8. |
abstract |
| p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis. | Borrelli, S, et al. Cell Death & Differentiation. 2008.epublication ahead of print:. |
abstract |
| Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer. | Bernard-Pierrot, I, et al. Cancer Res. 2008.68: 7165-75. |
abstract |
| Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth. | Bao, S, et al. Cancer Research. 2008.68:6043. |
abstract |
| HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity. | Azran-Shaish, I, et al. J Mol Med. 2008.86: 799-814. |
abstract |
| Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains. | Al-Hakim, AK, et al. Biochem J. 2008. |
abstract |
| Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth. | Ahmed, A, et al. JNCI Journal of the National Cancer Institute. 2008.epublication ahead of print:. |
abstract |
| Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. | Yang, L, et al. J Biol Chem. 2007.282: 10981-7. |
abstract |
| Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells. | Villa-Moruzzi, E, Biochem J. 2007.408: 7-18. | abstract |
| Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. | Vander Haar, E, et al. Nat Cell Biol. 2007.9: 316-23. |
abstract |
| The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. | Scholl, C, et al. J Clin Invest. 2007.117: 1037-48. |
abstract |
| Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. | Schmidt, RL, et al. Cancer Res. 2007.67: 11798-810. |
abstract |
| Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease. | Sanchez-Sanchez, F, et al. J Biol Chem. 2007.282: 27810-24. |
abstract |
| The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. | Rizzi, M, et al. J Leukoc Biol. 2007.81: 1599-608. |
abstract |
| c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. | Ravitz, MJ, et al. Cancer Res. 2007.67: 11209-17. |
abstract |
| Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. | Qian, YW, et al. J Lipid Res. 2007.48: 1488-98. |
abstract |
| Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression. | Pottier, N, et al. Hum Mol Genet. 2007.16: 2261-71. |
abstract |
| BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. | Patel, JH, et al. J Biol Chem. 2007.282: 5-13. |
abstract |
| Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse Development. | Pallerla, SR, et al. Dev Dyn. 2007.236: 556-63. |
abstract |
| Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. | Neilson, LM, et al. Mol Endocrinol. 2007.21: 2218-32. |
abstract |
| HOXB13 promotes ovarian cancer progression. | Miao, J, et al. Proc Natl Acad Sci U S A. 2007.104: 17093-8. |
abstract |
| Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells. | Liau, SS, et al. Br J Cancer. 2007.96: 993-1000. |
abstract |
| TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland. | Lee, NO, et al. Biochem Biophys Res Commun. 2007.362: 193-9. |
abstract |
| Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. | Lee, H, et al. Mol Cell Biol. 2007.27: 2103-19. |
abstract |
| Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA. | Kim, JS, et al. Mol Cell Biol. 2007.27: 662-77. |
abstract |
| GATA-6 mediates human bladder smooth muscle differentiation: involvement of a novel enhancer element in regulating alpha-smooth muscle actin gene expression. | Kanematsu, A, et al. Am J Physiol Cell Physiol. 2007.293: C1093-102. |
abstract |
| A screen of shRNAs targeting tumor suppressor genes to identify factors involved in A549 paclitaxel sensitivity. | Ji, D, et al. Oncol Rep. 2007.18: 1499-505. |
abstract |
| Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis. | Hirai, Y, et al. J Cell Sci. 2007.120: 2032-43. |
abstract |
| cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis. | Guicciardi, ME, et al. Am J Physiol Gastrointest Liver Physiol. 2007.292: G1337-46. |
abstract |
| Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? | Grimm, D, et al. J Clin Invest. 2007.117: 3633-41. |
abstract |
| Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. | Gatot, JS, et al. J Biol Chem. 2007.282: 31131-46. |
abstract |
| Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. | Frohling, S, et al. Cancer Cell. 2007.12: 501-13. |
abstract |
| Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor. | Fang, HL, et al. J Pharmacol Exp Ther. 2007.323: 586-98. |
abstract |
| Heat shock factor 1 is a powerful multifaceted modifier of Carcinogenesis. | Dai, C, et al. Cell. 2007.130: 1005-18. |
abstract |
| EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. | Cortina, C, et al. Nat Genet. 2007.39: 1376-83. |
abstract |
| Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer. | Chiappetta, G, et al. Endocr Relat Cancer. 2007.14: 405-20. |
abstract |
| Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage. | Cheng, A, et al. J Neurosci. 2007.27: 3722-33. |
abstract |
| Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification. | Carrithers, MD, et al. J Immunol. 2007.178: 7822-32. |
abstract |
| Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells. | Bush, CR, et al. J Biol Chem. 2007.282: 23387-401. |
abstract |
| Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. | Binne, UK, et al. Nat Cell Biol. 2007.9: 225-32. |
abstract |
| Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. | Bar, EE, et al. Stem Cells. 2007.25: 2524-33. |
abstract |
| Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. | Yousefi, S, et al. Nat Cell Biol. 2006.8: 1124-32. |
abstract |
| Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. | Takeda, S, et al. Genes Dev. 2006.20: 2397-409. |
abstract |
| Acetylation of the p53 DNA-binding domain regulates apoptosis induction. | Sykes, SM, et al. Mol Cell. 2006.24: 841-51. |
abstract |
| Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling. | Smoak, K, et al. Mol Cell Biol. 2006.26: 9126-35. |
abstract |
| Genome-scale loss-of-function screening with a lentiviral RNAi library. | Root, DE, et al. Nat Methods. 2006.3: 715-9. |
abstract |
| Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma. | Liau, SS, et al. J Gastrointest Surg. 2006.10: 1254-62; discussion 63. |
abstract |
| HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma. | Liau, SS, et al. Cancer Res. 2006.66: 11613-22. |
abstract |
| Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. | Fu, Z, et al. Mol Cell Biol. 2006.26: 8639-54. |
abstract |
| PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0. | Everett, RD, et al. J Virol. 2006.80: 7995-8005. |
abstract |
| Axl receptor activation mediates laminar shear stress anti-apoptotic effects in human endothelial cells. | D'Arcangelo, D, et al. Cardiovasc Res. 2006.71: 754-63. |
abstract |
| Genome-wide application of RNAi to the discovery of potential drug targets. | Ito, M, et al. FEBS Lett. 2005.579: 5988-95. |
abstract |
| Stable suppression of gene expression in murine embryonic stem cells by RNAi directed from DNA vector-based short hairpin RNA. | Tang, FC, et al. Stem Cells. 2004.22: 93-9. |
abstract |
| Lentivirus-delivered stable gene silencing by RNAi in primary cells. | Stewart, SA, et al. RNA. 2003.9: 493-501. |
abstract |
| Induction of an interferon response by RNAi vectors in mammalian cells. | Bridge, AJ, et al. Nat Genet. 2003.34: 263-4. |
abstract |
| Promoter choice affects the potency of HIV-1 specific RNA interference. | Boden, D, et al. Nucleic Acids Res. 2003.31: 5033-8. |
abstract |
| back to top | ||
| Broad Publications | ||
| Title | Author / Journal | Abstract |
| Forward RNAi screens in primary human hematopoietic stem/progenitor cells. | Ali, N et al. Blood 2009. epublication ahead of print |
abstract |
| Identification of RPS14 as a 5q-syndrome gene by RNA interference screen | Ebert, BL et al. Nature 2008. 451: 335-9 |
abstract |
| Interferon regulatory factors are transciptional regulators of adipogenesis | Eguchi, J et al. Cell Metab 2008. 7: 86-94 |
abstract |
| CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity | Firestein, R et al. Nature 2008. 455: 547-51 |
abstract |
| Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles | Frohling, SC et al. Cancer Cell 2007. 12: 501-13 |
abstract |
| Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3 | Jones, DC et al. Science 2006. 312:1223-7 |
abstract |
| Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL | Oberdoerffer, S et al. Science 2008. 321: 686-91 |
abstract |
| A mitochondrial protein compendium elucidates complex I disease biology | Pagliarini, DJ et al. Cell 2008. 134: 112-23 |
abstract |
| The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis | Scholl CD et al. JCI 2007. 117:1037-48 |
abstract |
| Inhibition of casein kinase 1-epsilon induces cancer-cellselective, PERIOD2-dependent growth arrest | Yang WS, et al. Genome Biol 2008. 9: R92. |
abstract |
| Integrative genomic approaches identify IKBKE as a breast cancer oncogene. | Boehm, J. S. et al. Cell 2007. 129: 1065-1079. |
abstract |
| Wild-type NRas and KRas perform distinct functions during transformation. | Fotiadou, P. P., Takahashi, C., Rajabi, H. N., Ewen, M. E. Mol. Cell. Biol. 2007. 27: 6742-6755. |
abstract |
| Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. | Kim, M. et al. Cell 2006. 125: 1269-1281. |
abstract |
| A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. | Moffat, J. et al. Cell 2006. 124: 1283-1298. |
abstract |
| PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. | Sancak, Y. et al. Mol. Cell 2007. 25: 903-915. |
abstract |
Contact Us
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