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siRNA

MISSION® In Vivo Quality siRNA Requirements


  • HPLC (≥90% pure):
    • This ensures ≥90% full-length product.

  • Removal of residual salts:
    • Depending on the scale, ethanol precipitation or ultra-filtration methods are performed.

  • Sterile filtration:
    • This minimizes bacteria, molds, and other contaminants.

  • Endotoxin tested:
    • Endotoxin testing (LAL) detects LPS, a constituent molecule found in the outer membrane of gram negative bacteria.
    • LPS must be below an acceptable threshold or the host will die from toxic shock as initiated by an immune cascade.

MISSION® iScale Oligos™ siRNA Requirements

MISSION® iScale Oligos™ siRNA is also available in standard desalt purification or HPLC purification so that researchers may order larger quantities of siRNA for other areas of research besides in vivo work.

Back to the MISSION® In Vivo Quality and iScale siRNA Webpage

Ready to order? Go to the MISSION® In Vivo Quality and iScale Oligos™ siRNA Inquiry and Order Request Form.


Contact Us
For questions about the library, pricing and quotes or other concerns, please email us at: MISSIONRNAi@sial.com.

MISSION is a registered trademark of Sigma-Aldrich Co. LLC Label License.

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