Cytokine and Growth Factor groups

The following table provides an overview of key cytokine and growth factor groups by receptor family as well as by classical family names and demonstrates the present characteristics and functionality at the family level.
Receptor Family Receptor Characteristics Members Common Activity Cytokine Characteristics
Hematopoietin – type 1 Cytosolic box 1 / 2 IL-6R
G-CSFR
gp130
IL-12R
T/B cell activation 4 α-helical bundles
  WSXWS extracellular sequence LIFR
IL-2Rβ
IL-2Rγ
IL-4R
IL-3Rα
IL-9R
GM-CSFR
IL-5R
Hematoiesis 4 α-helical bundles
Interferon – type 2 Cytosolic box 1 / 2,
Extracellular
Fibronectin domain
IFN-α/βR
IFN-R-α/β
IL-10R
Anti-viral
(not IL-10)
4 α-helical bundles
Tumor Necrosis Factor Cytosolic death domain
Four Cys-rich extracellular regions
P55 TNFR
P75 TNRR (no death domain)
LTβR
NGFR
CD40
CD30
CD27
4-1BB
OX40
TRAMP (DR3)
TRAILR (DR4)
Proinflammatory Jelly roll motif
Interleukin-1 / Toll-like Cytosolic Toll / IL-1R (TIR) domain
Ig domains (IL-1R)
Leucine-rich repeats (extracellular TLR subgroup)
IL-1RI
IL-1RII(no TIR)
IL-1RacP
IL018R α/β-chains
T1/ST2
IL-1RAPL
SIGIRR TLR1-TLR10
Proinflammatory β-trefoil
Tyrosine Kinase Cytosolic tyrosine
kinase domain
M-CSFR
EGFR
TGF
IGFs
FGF's
Growth Factors β-sheet
Chemokine 7 trans-membrane regions IL-8
MCP's
RANTES
Eotaxin
Chemotaxis Triple-stranded antiparallel β-sheet Greek key motif
(from The Cytokine Facts Book, 2nd Ed.Fitzgerald et al, Academic Press, 2001)