Figure 2.
In vitro binding of VDR protein to the HLA-DRB1*15 VDRE.
Electrophoretic mobility shift assay showing binding of recombinant VDR and retinoic acid receptor beta (RXR) to radiolabelled oligoduplex probe corresponding to the VDRE in the proximal HLA-DRB1 promoter region for the HLA-DRB*15 haplotype. Two specific complexes are indicated, denoted I and II, together with a supershifted complex shown by an * symbol in the presence of antibody to VDR. doi:10.1371/journal.pgen.1000369.g002