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BioFiles Volume 5, Number 6 — Cancer

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Table of Contents

 


Selected Cell Lines for Cancer Research

Cancer is a complex phenomenon. A specific type of cancer can vary in terms of markers and disease affected pathways from patient to patient or even from cell to cell within a specific tumor.1-3 Established cell lines provide a valuable tool in limiting the variables, allowing the study of specific pathways and causes. Today cell lines are used in the study of carcinogenesis,4 chemoprevention,5 cell signaling and drug sensitivity.6

Sigma® has partnered with the European Collection of Cell Cultures (ECACC) to offer a variety of cancer-derived cell lines. All cell lines have been authenticated and are mycoplasma tested. Sigma offers these and other cell lines to ensure you have the right tools to facilitate the complex task of cancer research. For a more extensive listing of cell lines, visit sigmaaldrich.com/ecacc. Check the site often as we are continually increasing our offering.



References

  1. Park, S.Y. et al. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J. Clin. Invest., 120, 636–644 (2010).
  2. Heppner, G.H. et al. Mammary tumor heterogeneity. Symp. Fundam. Cancer Res., 36, 209–221 (1983).
  3. Heppner, G.H. et al. Tumor heterogeneity: biological implications and therapeutic consequences. Cancer Metastasis Rev., 2, 5–23 (1983).
  4. Pilli, T. et al. Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer. Thyroid, 19, 1333–42 (2009).
  5. Cuendet, M. et al. Quinone reductase induction as a biomarker for cancer chemoprevention. J. Nat. Prod., 69, 460–463 (2006).
  6. Sharma, S.V. et al. Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat. Rev. Cancer, 10, 241–53 (2010).

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