BioFiles Volume 5, Number 7 — Lipid Metabolism

Download BioFiles v5 n7 (PDF)

 

Table of Contents

 


Many natural compounds contain tailor-made lipid anchors or lipid-like functional groups intended to localize them on the cellular membrane. Natural products with lipid anchors are of interest for a number of cell migration processes of healthy and diseased cells like wound healing, blood vessel formation, immune system function, and tumor metastasis. Certain lipid components of the cell membrane itself, such as phosphatidylglycerol, cardiolipin, or glycosylphosphatidylinositol, can also serve directly as anchors. These phospholipids are listed in the section on natural abundance lipid metabolites.

Lipids in the cell walls and membranes of pathogenic microorganisms and their related pathways are of particular interest for the development of novel bioactive compounds, especially if they have no eukaryotic counterparts. Antibiotics like the phosphoglycolipids are the only known active site inhibitors of the peptidoglycan glycosyltransferases, which are involved in the biosynthesis of the bacterial cell wall. The lipoteichoic acids of the cell wall of Gram-positive bacteria, anchored by their diacylglycerol moiety, are recognized by the innate immune system, making them an interesting scaffold for new approaches to natural therapeutic products. In Gram-positive bacteria, lipid A is of interest for the development of immunostimulating compounds and vaccine adjuvants.

The biosynthesis of eicosanoids such as prostaglandins, thromboxanes, and leukotrienes begins with arachidonic acid and involves a series of enzymatic reactions including radical formation, reaction with oxygen and cyclization, and reduction. Polyacetylenic natural products contain a unique carbon-carbon triple bond and have a wide variety of biochemical and ecological functions. Initial departure points from primary metabolism include the three fatty acids crepenynic acid, stearolic acid, and tariric acid.

Description Product No.
Acetyl coenzyme A trilithium salt A2181-1MG
A2181-5MG
A2181-10MG
A2181-25MG
A2181-100MG
Acetyl coenzyme A sodium salt A2056-1MG
A2056-5MG
A2056-10MG
A2056-25MG
A2056-100MG
Coniferyl alcohol 223735-100MG
223735-1G
Farnesyl pyrophosphate ammonium salt F6892-1VL
F6892-5VL
Geranylgeranyl pyrophosphate ammonium salt G6025-1VL
G6025-5VL
Isopentenyl pyrophosphate trilithium salt 00297
Isopentenyl pyrophosphate triammonium salt solution I0503-1VL
I0503-5VL
Malonyl coenzyme A tetralithium salt 63410-10MG-F
63410-50MG-F
Malonyl coenzyme A lithium salt M4263-5MG
M4263-10MG
M4263-25MG
M4263-100MG
Lipoteichoic acid from Streptococcus pyogenes L3140-5MG
L3140-10MG
L3140-25MG
Lipoteichoic acid from Streptococcus faecalis L4015-5MG
L4015-25MG
Lipoteichoic acid from Staphylococcus aureus L2515-5MG
L2515-10MG
L2515-25MG
Lipoteichoic acid from Bacillus subtilis L3265-1MG
L3265-5MG
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant) L6895-1MG
L6895-5MG
Lipid A, monophosphoryl from Escherichia coli F583 (Rd mutant) L6638-1MG
L6638-5MG
Lipid A, diphosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant) L0774-1MG
L0774-5MG
Lipid A, diphosphoryl from Escherichia coli F583 (Rd mutant) L5399-1MG
L5399-5MG
L-NASPA P0247-1MG
P0247-5MG

back to BioFiles v5 n7
back to top