Enzyme Explorer

Matrix Metalloproteinases

MMP 1, 3, 8, 10, 12, 13, 18, 19, 20, 22, 27 & 28


MMP Alternative Name EC Number Substrates
MMP-1 Collagenase (Type I, interstitial)
3.4.24.7
Collagens (I, II, III, VII, VIII, and X); gelatin; aggrecan; L-selectin; IL-1beta; proteoglycans; entactin; ovostatin; MMP-2; MMP-9
MMP-3 Stromelysin-1, Proteoglycanase
3.4.24.17
Collagens (III, IV, V, and IX); gelatin; aggrecan; perlecan; decorin; laminin; elastin; caesin; osteonectin; ovostatin; entactin; plasminogen; MBP; IL-1beta; MMP-2/TIMP-2; MMP-7; MMP-8; MMP-9; MMP-13
MMP-8 Neutrophil collagenase
3.4.24.34
Collagens (I, II, III, V, VII, VIII, and X); gelatin; aggrecan; fibronectin
MMP-10 Stromelysin-2
3.4.24.22
Collagens (III-V); gelatin; casein; aggrecan; elastin; MMP-1; MMP-8
MMP-12 Macrophage metalloelastase
3.4.24.65
Collagen IV; gelatin; elastin; casein; fibronectin; vitronectin; laminin; entactin; MBP; fibrinogen; fibrin; plasminogen
MMP-13 Collagenase-3
*
Collagens (I, II, III, IV, IX, X, and XIV); gelatin; plasminogen;aggrecan; perlecan; fibronectin; osteonectin; MMP-9
MMP-18 Xenopus Collagenase-4
*
Type I collagen
MMP-19 RASI
*
Type I collagen
MMP-20 Enamelysin
3.4.24
Amelogenin; aggrecan, and cartilage oligomeric matrix protein (COMP)
MMP-22 Chicken MMP (C-MMP)
*
Unknown
MMP-27  
*
Unknown
MMP-28 Epilysin
*
Unknown

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MMP 2


MMP Alternative Name EC Number Substrates
MMP-2 Gelatinase A 72 kDa Gelatinase Type IV Collagenase
3.4.24.24
 

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MMP 7 & 26


MMP Alternative Name EC Number Substrates
MMP-7 Matrilysin; PUMP
3.4.24.23
Collagens (IV and X); gelatin; aggrecan; decorin; fibronectin; laminin; entactin; elastin; casein; transferrin; plasminogen; MBP; Beta4-intergrin; MMP-1; MMP-2; MMP-9; MMP-9/TIMP-1
MMP-26 Matrilysin-2; Endometase
*
Collagen IV, fibronectin, fibrinogen, gelatin, alpha (1)-proteinase inhibitor

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MMP 9


MMP Alternative Name EC Number Substrates
MMP-9 Gelatinase B
3.4.24.35
Collagens (IV, V, VII, X, and XIV); gelatin; entactin; aggrecan; elastin; fibronectin; osteonectin; plasminogen; MBP; IL-1beta

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MMP 11


MMP Alternative Name EC Number Substrates
MMP-11 Stromelysin-3
3.4.24
Unknown (casein)

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MMP 14, 15, 16, 24


MMP Alternative Name EC Number Substrates
MMP-14 MT1-MMP
3.4.24
Collagens (I-III); gelatin; casein; fibronectin; laminin; vitronectin; entactin; proteoglycans; MMP-2; MMP-13
MMP-15 MT2-MMP
3.4.24
Fibronectin; entactin; laminin; aggrecan; perlecan; MMP-2
MMP-16 MT3-MMP
3.4.24
Collagen III; gelatin; casein; fibronectin; MMP-2
MMP-24 MT5-MMP
*
Fibronectin, but not collagen type I nor laminin

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MMP 17 & 25


MMP Alternative Name EC Number Substrates
MMP-17 MT4-MMP
3.4.24
Unknown
MMP-25 MT6-MMP; leukolysin
*
Pro-gelatinase A

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MMP 21 & 23


MMP Alternative Name EC Number Substrates
MMP-21 Xenopus MMP (X-MMP)
*
Unknown
MMP-23 Cysteine Array Matrix Metalloproteinase (CA-MMP)
*
Unknown

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* EC Number not assigned.