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Enzyme Explorer

Plasma Protein Composition


Prealbumin, thyroxine-binding
Retinol-binding protein
Albumin
Galactoglycoprotein
α-Globulins
β-Globulins
Low-molecular weight proteins
Complement components
Other complement factors
Coagulation proteins
Immunoglobulins

Plasma & Blood Protein Resource


Protein Symbol Molecular Weight Amount in Normal Serum (plasma) (mg/100ml) Carbohydrate Content (%)
Prealbumin, thyroxine-binding TBPA 54,980 10-40 0
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Retinol-binding protein RBP 21,000 3-6 0
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Albumin Alb 66,500 3,500 - 5,000 0
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Galactoglycoprotein GGP 81,000 76
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α-Globulins        
   α1-Acid glycoprotein α1S 40,000 55-140 42
   α1-Antitrypsin α1AT 54,000 200-400 13
   α1-Fetoprotein α1F 66,300 ~1µg 3
   9.5 S α1-Glycoprotein (serum amyloid P protein) α1M, SAP ~250,000 3-8 13
   GC Globulin Gc 52,000 20-55 4
   Ceruloplasmin Cp 132,000 15-60 7
   3.8 S Histidine-rich α2-glycoprotein HRG 58,500 5-15 11
   α2-Macroglobulin α2M 725,000 150-420 9.4
   4 S α2, β1-Glycoprotein 60,000 Trace 28
   α1B-Glycoprotein α1B 68,000 15-30 13
   α1T-Glycoprotein α1T 85,000 5-12 15
   α1-Antichymotrypsin α1X 68,000 30-60 26
   α1-Microglobulin α1m 26,000 4-9 20
   Zn-α2-Glycoprotein Znα2 41,000 2-15 18
   α2HS-Glycoprotein α2HS 49,000 40-85 14
   Pregnancy-associated α2-glycoprotein α2PAG 360,000 Trace  
   3.1 S Leucine-rich α2-glycoprotein LRG 49,600 2-3 23
   8 S α3-Glycoprotein 8Sα3 220,000 3-5  
   Serum cholinesterase CE 348,000 0.5-1.5  
   Thyroxine-binding globulin TBG 54,000 1-2 20
   Inter-α-trypsin inhibitor IαI ~160,000 20-70 8
   Transcortin TC 55,700 ~7  
   Haptoglobin Hp     16.4
      Type 1-1 86,000 100-220  
      Type 2-1 ~200,000 160-300  
      Type 2-2 ~400,000 120-260  
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β-Globulins        
   Hemopexin Hpx 60,000 50-115 22
   Transferrin Tf 79,500 200-320 5.9
   β2-Microglobulin β2m 11,730 Trace 0
   β2-Glycoprotein I β2I ~48,000 15-30 19
   β2-Glycoprotein II GGG 63,000 12-30 10
      (C3 proactivator) C3PA
   β2-Glycoprotein III β2III 35,000 5-15 10
   C-Reactive Protein CRP 105,000 <1 0
   Fibronectin Fn 440,000 25-40  
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Low-molecular weight proteins        
   Lysozyme   14,000 0.5-1.5  
   Basic protein B1 B1 11,000  
   Basic protein B2 B2 8,800 <1 0
   0.6 S γ2-Globulin 5,100 <1 0
   2 S γ2-Globulin 14,000 0.1 0
   Post γ-globulin 13,260 0
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Complement components C      
   C1q Component C1q 400,000 10-25 9
   C1r Component C1r 166,000 9.4
   C1s Component C1s 83,000 1-2 7.1
   C2 Component C2 102,000 2-3  
   C3 Component C3 185,000 55-120 2
   C4 Component C4 200,000 20-50 7
   C5 Component C5 185,000 4-15 1.6
   C6 Component C6 105,000 7 3.8
   C7 Component C7 92,500 6 6.4
   C8 Component C8 163,000 8  
   C9 Component C9 71,000 23  
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Other complement factors        
   C1 Esterase inhibitor C1-INA 104,000 15-35  
   Factor B B 90,000 6
   Factor D D 24,000  
   Factor H H 155,000 9.3
   C4 Binding Protein C4bp 540,000  
   Properdin P 220,000 2-3 10
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Coagulation proteins        
   Antithrombin III ATIII 58,000 (20-40) 15
   Prothrombin FII 72,000 (5-10) 12
   Antihemophilic factor (Factor VIII) AHF, FVIII (100,000)n (1-2)  
   Plasminogen Pmg 92,000 (6-25) 1.5
   Fibrin-stabilizing factor (Factor XIII) FXIII 320,000 (1-4) 4.9
   Fibrinogen F1 340,000 200-450 4
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Immunoglobulins Ig      
   Immunoglobulin G IgG 150,000 800-1800 3
   Immunoglobulin A IgA (160,000)n 90-450 8
   Immunoglobulin M IgM 950,000 60-250 10
   Immunoglobulin D IgD 175,000 <15 9
   Immunoglobulin E IgE 190,000 <0.06 9
   κ Bence Jones protein κBJP 23,000 Trace 0
   γ Bence Jones protein γBJP 23,000 Trace 0

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A special thanks to Frank Putnam for allowing us to replicate information referenced from "The Plasma Proteins", Volume IV, 2nd Edition, 1984, Frank W. Putnam.