Enzyme Explorer

Renin-Angiotensin System



Renin-Angiotensin Pathway
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Human recombinant Renin now available
More than 30% of the US population suffers from some degree of hypertension and over 20,000 deaths attributed to hypertension were recorded in 2002 in the US. Many of the drugs prescribed for hypertension have been designed to regulate blood pressure at various points in the Renin-Angiotensin System (RAS). The renin-angiotensin system is considered one of the key modulators of blood volume / pressure, cardiac and vascular function. The RAS pathway is common to many tissues. However, the most notable occurrence of this pathway is in the kidney. This protein is available
in the BioUltra Grade.

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  • The RAS pathway is a cascade beginning with the production of angiotensinogen in the liver.
  • Sympathetic stimulation of β1-adrenoceptors, renal artery hypotension, and decreased sodium in the distal tubules stimulate the release of renin by the kidney. Renin hydrolyzes angiotensinogen to yield the relatively inactive precursor angiotensin I.
  • Angiotensin I is cleaved by angiotensin converting enzyme (ACE) to yield active angiotensin II (ATII).
  • Angiotensin II then acts on AT1 receptors to stimulate systemic vasoconstriction and expression of plasminogen activator inhibitor (PAI).
  • Conversely Angiotensin II binding to AT2 receptors may cause vasodialation and apoptosis.
  • ATII acts on the adrenal cortex to stimulate aldosterone production, which in turn stimulates sodium resorption from the distal tubules.

 

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Plasma & Blood Protein Resource