Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Plant Profiler

Cramp bark (Viburnum opulus)


Cramp bark (Viburnum opulus) Image
Synonyms / Common Names / Related Terms
American guelder-rose, Caprifoliaceae (family), common guelder-rose, cranberry tree, European cranberry bush, guelder rose, pembina, proanthocyanidins, snowball tree, Viburnum opulus, Viburnum opulus L., Viburnum prunifolium L. , viopudial.






Mechanism of Action

Pharmacology:

  • Constituents: Cramp bark contains proanthocyanidins and viopudial.2,1 The squeezed berries of cramp bark contain polysaccharides, including galacturonic acid, galactose, arabinose, mannose, and rhamnose.6 Urosolic acid has been extracted from the flowers.7
  • Antimicrobial activity: Viburnum opulus has exhibited disinfectant activity.5
  • Antioxidant activity: In an animal study, Viburnum opulus increased the activity of superoxide dismutase, catalase, and gluthatione peroxidase.2 In an in vitro study, Viburnum opulus extract also showed antioxidant activity.3
  • Antispasmodic activity: In vitro, viopudial isolated from Viburnum opulus has shown antispasmodic effects on smooth muscle.1
  • Astringent activity: In an in vitro study, Viburnum opulus extract showed astringent activity.4
  • Gastroduodenoprotective activity: In a study of stressed rats, Viburnum opulus PA prevented gastroduodenal mucosal damage.2
  • Hypotensive effects: In vitro, viopudial isolated from Viburnum opulus has shown hypotensive effects.1
  • Immunostimulating effects: Some polysaccharides from Viburnum opulus berries enhanced phagocytosis, in particular, the phagocytic index and the secretion of lysosomal enzymes with peritoneal macrophages.6

Pharmacodynamics/Kinetics:

  • Insufficient available evidence.

References

  1. Nicholson, J. A., Darby, T. D., and Jarboe, C. H. Viopudial, a hypotensive and smooth muscle antispasmodic from Viburnum opulus. Proc Soc Exp Biol Med  1972;140(2):457-461. 5037580
  2. Zayachkivska, O. S., Gzhegotsky, M. R., Terletska, O. I., Lutsyk, D. A., Yaschenko, A. M., and Dzhura, O. R. Influence of Viburnum Opulus proanthocyanidins on stress-induced gastrointestinal mucosal damage. J Physiol Pharmacol 2006;57 Suppl 5:155-167. 17218766
  3. Ryzhikov, M. A. and Ryzhikova, V. O. [Application of chemiluminescent methods for analysis of the antioxidant activity of herbal extracts]. Vopr Pitan  2006;75(2):22-26. 16729755
  4. Smirnova, A. S. and Iadrova, V. M. [Comparative study of the astringent effect of liquid extracts from Viburnum opulus L]. Farmatsiia  1968;17(4):42-45. 5759831
  5. Smetankina, P. P. [DISINFECTANT PROPERTIES OF VIBURNUM OPULUS.]. Vestn Dermatol Venerol  1963;37:75. 14068300
  6. Ovodova, R. G., Golovchenko, V. V., Popov, S. V., Shashkov, A. S., and Ovodov, IuS. [The isolation, preliminary study of structure and physiological activity of water-soluble polysaccharides from squeezed berries of Snowball tree Viburnum opulus]. Bioorg Khim  2000;26(1):61-67. 10806553
  7. Plouvier, V. [PRESENCE OF URSOLIC ACID IN THE BLOSSOMS OF VIBURNUM OPULUS L. VAR. STERILE DC (CAPRIFOLIACEAE)]. Ann Pharm Fr  1964;22:313-314. 14197758




Licensed by Natural Standard Copyright © 2010 by Natural Standard Corporation. All Rights Reserved.

back to Plant Profiler
back to top