Cell Lysis & Protein Expression

Protease Inhibitor Cocktails

The  complete Sigma-Aldrich line of Protease Inhibitor Cocktails offers a diverse portfolio that accommodates your different sample needs.  Specialized cocktails are available for various sample forms:

  • Bacterial cells
  • Mammalian tissues and cells
  • Plant tissues and cells
  • Histdine-tagged (HIS-tagged) proteins.

Our portfolio also includes protease inhibitor cocktails that are tailored to specific applications:

  • We offer cocktails for customers who require animal component-free (ACF) protease inhibitor cocktails in their work.
  • We also now offer the only fully mass spectrometry-compatible protease inhibitor cocktail and phosphatase inhibitor cocktail on the market, MSSAFE.

Our Protease Inhibitor Cocktails have been optimized to maintain and preserve protein functionality following cell lysis, and are available in powder, solution, or tablet forms. Component information for our cocktails is available in the table below:

 Protease Inhibitor Cocktails

 
Product Number P2714 S8820 P1860 P8465 P8340 P8849 S8830 P8215 P9599 I3911 I3786 MSSAFE
  General
Use
General
Use
Tissue
Culture
Bacterial
Cells
Mammalian
Tissues
Histidine-
Tagged
Proteins
Histidine-
Tagged
Proteins
Fungal/
Yeast
Cells
Plant
Cells
General
Use
(Animal
Component
Free/ACF)
Mammalian
Cells and
Tissues
(Animal
Component
Free/ACF)
Mammalian
Cells and
Tissues
  Lyophilized
powder -
Water
Soluble
Tablet -
Water
Soluble
Solution
in
DMSO
Lyophilized
powder -
Vial of
DMSO
Solution
in DMSO
Solution
in DMSO
Tablet -
Water
Soluble
Solution
in DMSO
Solution
in DMSO
Lyophilized
powder
(water
soluble)
Solution
in DMSO
Lyophilized
powder
(water
soluble)
AEBSF Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes  
Aprotinin Yes Yes Yes   Yes        
Bestatin Yes Yes Yes Yes Yes Yes Yes   Yes
EDTA Yes Yes   Yes              
E-64 Yes Yes Yes Yes Yes Yes Yes Yes Yes  
Leupeptin Yes Yes Yes   Yes       Yes
Pepstatin A     Yes Yes Yes Yes Yes Yes Yes  
Phosphoramidon           Yes Yes        
1,10-Phenanthroline               Yes Yes      
Elastinal                      
Nafamostat mesylate                      
Antipain