Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

HyStem™ Cell Culture

What is Hyaluronan?

Brief Summary
Hyaluronic acid (HA) is the simplest glycosaminoglycan (a class of negatively charged polysaccharides) and a major constituent of the extracellular matrix (ECM)1. Hyaluronan is a scaffold secreted by cells that surrounds them in vivo2. HA is a linear, non-sulfated polysaccharide that provides compression strength, lubrication and hydration within the ECM2. It also regulates cell adhesion and motility3,4 and mediates cell proliferation and differentiation5 making it not only a structural component of tissues, but also an active, signaling molecule.