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Late Stage Functionalization

Starters & EssentialsFunctionalizationPurification Analysis

Purification Analysis
 

Monitor reaction progress, then purify and characterize your optimized lead compounds.

Products

Reaction Monitoring- TLC Plates


Purification- Silica Gels


Characterization- NMR Tubes & Solvents

Select TLC Plates

Product No. Description
Z122882 Sigma-Aldrich® TLC Plates, PEI-cellulose, matrix
Z265489 Analtech TLC Uniplates™: C18-silica gel matrix
Z513032 Preparative TLC plates, Silica Gel
56524 Silica gel on TLC Al foils, with fluorescence indicator
254 nm

 

Select Silica Gel

Product No. Description
214477 Silica gel, high-purity grade (Davisil Grade 923), pore size 30 Å, 100-200 mesh
227196 Silica gel, high-purity grade (Merck Grade 9385), pore size 60 Å, 230-400 mesh particle size
60741 Silica Gel, high-purity grade, pore size 60 Å, 70-230 mesh, 63-200 μm, for column chromatography
60752 Silica Gel, high-purity grade (w/ Ca, ~0.1%), pore size 60 Å, 230-400 mesh particle size
717185 Silica Gel, technical grade, pore size 60 Å, 230-400 mesh particle size, 40-63 μm particle size

 

Select NMR Solvents

Product No. Description
151793 Acetone-d6
151807 Acetonitrile-d3
151815 Benzene-d6
151823 Chloroform-d
151882 Deuterium oxide
177865 Dichloromethane-d2
151874 Dimethyl sulfoxide-d6
151947 Methanol-d4

 

Literature & Resources

 

Offers on LPLC & TLC Products
Save when you spend with our up-to-date promotions for TLC and Flash Chromatography solutions.


 

Drug Discovery Workflow
Sigma-Aldrich's comprehensive offer in Drug Discovery, from Target ID & Validation, Lead Discovery & Optimization, through Pre-Clinical into commercial manufacture.

Chiral Columns and Chiral Separation Services are highlighted herein. Notably, Sigma-Aldrich provides Astec CHIROBIOTIC™ technology- top of the line macrocyclic glycoprotein stationary phase columns for chiral, and highly selective achiral, separations.

Products

Astec CHIROBIOTIC Chiral Columns

Astec CHIROBIOTIC T2 Solid Phase Columns
Astec® CHIROBIOTIC® T2 is based on bonding the amphoteric glycopeptide Teicoplanin to high-purity silica gel through multiple covalent linkages. Teicoplanin contains 23 chiral centers surrounding four pockets or cavities. It has complementary stereoselectivity to CHIROBIOTIC® V, R, and T. Neutral compounds can often be run in pure methanol, and selectivity for basic compounds is excellent.

 

Product No. Description
16018AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
16022AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
16019AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
16023AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
16020AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
16044AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 21.2 mm
16024AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
16124AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 10 μm particle size, L × I.D. 25 cm × 4.6 mm
16021AST Astec® CHIROBIOTIC® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 5 cm × 4.6 mm

Astec CHIROBIOTIC V Solid Phase Columns
Astec® CHIROBIOTIC® V is based on bonding vancomycin, which contains 18 chiral centers surrounding three pockets or cavities, to high-purity silica gel. CHIROBIOTIC® V has demonstrated broad selectivity in reversed phase, normal phase, and polar organic phase modes.




Product No. Description
11018AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 2.1 mm
11010AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 3 mm
11022AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
11019AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
11023AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
11034AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 10 mm
11020AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
11044AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 21.2 mm
11024AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 5 cm × 4.6 mm
11021AST Astec® CHIROBIOTIC® V Chiral HPLC Column, 5 μm particle size, L × I.D. 5 cm × 4.6 mm

Literature & Resources

 

CHIROBIOTIC Method Development Kit
Learn more about our most popular solid phases and column dimensions, complete with CHIROBIOTIC guidebook.

 

Chiral Method Development Guide
Develop a chromatographic method for even the hardest chiral separations with our CHIROBIOTIC columns and our Chiral Method Development Guide.

 

Drug Discovery Workflow

Sigma-Aldrich’s comprehensive offer in Drug Discovery, from Target ID & Validation, Lead Discovery & Optimization, through Pre-Clinical into commercial manufacture.

Late Stage Functionalization allows you to quickly diversify your Lead compound; rapid HPLC analysis is also possible with Ascentis Express HPLC chromatography columns. Run your analyses in a fraction of the time!

Products

Ascentis Express

Titan Columns

Literature & Resources
 

Fast HPLC Application Support
Let us help you achieve fast, well-defined peaks through Ascentis Express Support.

 
HPLC Accessories Brochure
Download our HPLC Accessories Brochure for everything you need to run and service your HPLC.

 
Drug Discovery Workflow
Sigma-Aldrich's comprehensive offer in Drug Discovery, from Target ID & Validation, Lead Discovery & Optimization, through Pre-Clinical into commercial manufacture.