Translational Research Solutions

Pre-Clinical Development

Process Chemistry

Enabling the transition from bench to plant with cutting-edge chemical technology and reliable sourcing services. New technologies  that enable greener, safer processes are also emphasized.

Scalable Separations

Sigma-Aldrich provides scalable separation services, including chiral resolutions and crystallization development. 

Chiral Separations

Simulated Moving Bed (SMB) Chromatography

Crystallization Development

ADME/Tox

Sigma-Aldrich’s ADME/Tox offering includes an arsenal of genetically modified cell lines that simplify in vitro membrane transporter research. These are complemented by testing services and a plethora of consumables for metabolism and toxicity assays to quickly identify non-viable candidates.

ADME/Tox

Pre-Formulation & Drug Delivery

Targeted drug delivery can be achieved through conjugation to antibodies or nanomaterials. Component synthesis and conjugation services also available for your API and HPAPI.