Hydrogel IPN Kits – COMING 2017

Localize Your Drug Delivery

Sigma-Aldrich® Materials Science offers two new ready-to-use hydrogel kits for the encapsulation and delivery of drugs, biomolecules, and cells. The hydrogels fuse the durability of synthetic polymers and the biorecognition of a natural protein to create a biocompatible delivery platform. The biodegradable matrix allows for temporally and spatially controlled delivery.
 

Applications

  • Drug Delivery of bioactives (small molecules, macromolecules, therapeutic cells) to treat or correct an underlying pathology. Such as:
    • Small molecules (anti-inflammatories and immunosuppressive agents1, anesthetics2,3
    • Macromolecules (growth factors2, fluorescently labeled molecules4
  • Cell encapsulation and delivery
    • Used to encapsulate stem cells to study, multipotency, differentiation, secretion, and cell-cell, cell-matrix interactions5
    • 3D cell entrapment to study matrix properties and impact on 3D cell culture6
    • Stem cell administration for wound healing7

Kits are scheduled to be available for purchase in 2017
 

Description Product No.
Photo-crosslinkable sIPN hydrogel kit   799610-1KT
Chemically crosslinkable sIPN hydrogel kit 799629-1KT

Storage: -20 °C
Ship on dry ice
 

Features

  • Hybrid biomaterials combine biological and synthetic components to tune desired biological, chemical, physical properties.
  • Biomatrix offers spatial, temporal, and functional control in presenting bioactives.
  • The biological, chemicophysical (i.e., degradation rate, porosity, etc) properties of the 3D matrix can be tuned depending on the formulation.
  • Photo or chemical crosslinking based upon need of application.

References

  1. Stevens, K.R.; Einerson, N.J.; Burmania, J.A.; Kao, W.J. In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks. J. Biomater. Sci., Polym. Ed. 2002,13, 1353-66.
  2. Fu Y.; Kao, W.J. Drug release kinetics and transport mechanisms from semi-interpenetrating networks of gelatin and poly(ethylene glycol) diacrylate. Pharm. Res. 2009, 26, 2115-24.
  3. Kleinbeck, K.R.; Bader, R.A.; Kao, W.J. Concurrent in vitro release of silver sulfadiazine and bupivacaine from semi-interpenetrating networks for wound management. J. Burn. Care. Res. 2009, 30, 98-104.
  4. Waldeck, H.; Kao, W.J. Effect of the addition of a labile gelatin component on the degradation and solute release kinetics of a stable PEG hydrogel. J. Biomater. Sci., Polym. Ed. 2012, 23, 1595-611.
  5. Cantu, D.A.; Hematti, P.; Kao, W.J. Cell encapsulating biomaterial regulates mesenchymal stromal/stem cell differentiation and macrophage immunophenotype. Stem Cells Transl. Med. 2012, 1, 740-9.
  6. Fu, Y.; Xu, K.; Zheng, X.; Giacomin, A.J.; Mix, A.W.; Kao, W.J. 3D cell entrapment in crosslinked thiolated gelatin-poly(ethylene glycol) diacrylate hydrogels. Biomaterials. 2012, 33, 48-58.
  7. Xu, K.; Cantu, D.A.; Fu, Y.; Kim, J.; Zheng, X.; Hematti, P.; et al. Thiol-ene Michael-type formation of gelatin/polyethylene-glycol biomatrices for 3-D mesenchymal stromal/stem cell presentation to cutaneous wounds. Acta Biomater. 2013, 9, 8802-14.