imMEDIAte ADVANTAGE™

Scale-up and Support Service

Small Volume Custom Media: imMEDIAte ADVANTAGE™

The work you do today defines the products of tomorrow. SAFC global development and support services are underpinned by more than 40 years of cell culture media manufacturing expertise to help you deliver high quality performing products.

Feasibility ‑ Scalability ‑ Manufacturability

Complex materials such as cell culture media are often a significant source of process variability. Our imMEDIAte ADVANTAGE™ laboratories in Lenexa, Kansas, St. Louis, Missouri, Irvine, Scotland and Singapore are dedicated to supporting the study and development of this critical component in your process. These labs are uniquely equipped to support developers and manufacturers alike with access to non-GMP small volume custom media with expedited timing. All media formulations are produced using comparable compounding methods and qualified raw materials where possible to provide the consistency in your development studies. With over 40 years of manufacturing experience, SAFC process and analytical scientist understand the need for scalability and routinely support efforts across all stages of development and manufacture.

  • Scale-down powder mill and blend process equipment (Lenexa, Kansas)
  • Use of Qualified Raw Materials
  • Formulation derivatives tracked and archived for reference

Validated Scale‑Down Process Equipment

The imMEDIAte ADVANTAGE Pin Mill is the same stainless steel pin mill design as the larger full-scale cGMP counterparts.

  • Process flow: pre-blend, pin mill, post-blend
  • Nitrogen gas: utilized to cool the mill and transport components after particle size reduction
  • Milling temperature: criteria is monitored: <40 °C
  • Lot size range: 0.5–20.0 Kg

ASSAY DESCRIPTION (ASSAY NUMBER)
Lipids / Fatty Acids (88101-1EA)
Lipids, phospholipids, free fatty acids, triglycerides, cholesterol esters, and total protein analysis by gas chromatography
(Results reported in mcg/mL)
Cholesterol (88102-1EA)
Cholesterol analysis performed by reverse phase HPLC.
(Results reported in mcg/mL)
Free Amino Acids (88103-EA)
Amino Acids separated and analyzed by HPLC.
(Results are reported as mg/L)
Standard Element – ICP (88119)
Standard elemental analysis by ICP-OES. Standard Elements: Calcium, Magnesium, Sodium, Sulphur, Potassium and Phosphate.
(Results reported in g/L)
Trace Element – ICP (88120)
Trace elemental analysis by ICP-OES. Trace Elements: Barium, Bismuth, Cadium, Cobalt, Chromium, Copper, Iron, Lithium, Manganese, Molybdenum, Nickel, Lead, Stronium, and Zinc.
(Results reported in ppm or mg/L)
Vitamin B12 w/ Folic Acid (88128-1EA)
Water-soluble vitamins, including B1 through B12, analysis by HPLC.
(Results reported in mg/L)
Glucose (88202)
Glucose measured by the hexokinase test method.
(Results reported in mg/dL)
Endotoxin (88204)
Endotoxin determined by kinetic chromogenic Limulus Amoebocyte Lysate method.
(Results reported in EU/mL or EU/g)
Osmolality (88206)
Osmolality determined by freeze-point depression.
(Results are reported in mOsm/kg H2O)
pH (88207)
pH measured with a pH meter.
(Results reported to nearest tenth)
Bioburden (88208)
Standard USP test for Bioburden using membrane  ltration.
(Results reported as CFU/g or CFU/100mL)
Appearance (88210)
Appearance determined by a standard operating procedure with consistent requirements for verbiage.
Solubility (88211)
Solubility determined by a standard operating procedure with requirement of soluble at 30 minutes at 25 °C, clear and free of particulate.
(Results are reported as satisfactory or unsatisfactory with a description of observation.)

Additional testing may be available upon request.
Contact your Account Representative for further assistance.

Process Support

Small volume custom powder and liquid media formulations provided within ten (10) business days1 ideal for:

  • Prototyping / Troubleshooting / Scale-up Studies
  • Upstream / Downstream Materials
  • Powder / Liquid / Liquid Concentrate

Analytical Support

Reliable component analysis from SAFC peer material and development scientists who are available to consult on results
within 15 business days or less.1

  • Material Science Support
  • Formulation Optimization

1 Does not include shipping

Technical Support
Do you have technical questions on any of our products? Contact our technical support team.
Customer Support
Are you already an existing customer?
Contact our customer support team.

Sales Support
Do you have questions on ordering
one of our products? Contact our sales
support team
.