Native Sourced Extraction & Purification

Proteins derived from natural plant and animal-based sources continue to be important components in the manufacture of key biologic drugs. With over 30 years of specialized experience in manufacturing extracted biologics materials, SAFC is at the forefront in supporting commercial biologics programs from clinical trials all the way through commercialization.

Our purpose built facilities can process multi-tons of biomass, producing up to 6.5 kg of purified biological protein products per week.

Purification Process Capabilities

  • Large, Class 100,000 (ISO 8) and Class 10,000 (ISO 7) suites
  • Suites capable of 1.5 m column chromatography
  • Unidirectional personnel and material flows
  • Proteins, adjuvants, and excipients product expertise
  • Delta-V digital system control
  • 200 L Lyophilization capacity

Purification of Plant-Based Proteins

Our St. Louis protein purification facility has the capability to add extraction processes to the purification scheme.

  • Up to 5,000 kg of plant-based biomass and 6.5 kg of therapeutic protein can be processed per week
  • Completely animal-free raw materials facility
  • Three large 2,500 L tanks for semi-continuous extraction enables high throughput

Purification of Animal-Based Proteins

A separate but complementary protein purification facility offers  similar purification scales dedicated to the extraction and purification of animal-sourced products within our St. Louis site.

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