Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.


Buchs, Switzerland

Small Molecule and Advanced Chemical Synthesis Manufacturing

SAFC Buchs has a long history of producing high-quality intermediates and bulk actives from Phase I to Phase III clinical trials.The plant specializes in complex, multi-step organic custom synthesis to 1,600 liters and low temperature reactions (-60°C) up to 400 liters. This cGMP, ISO certified site offers batch sizes from grams to tons and provides a wide range of development and production capabilities, including Simulated Moving Bed (SMB) chromatography and flow chemistry technology.

For more information, view the Buchs facility insert (PDF).

Core Technologies

50-500 GA, (200-2,000L)

Core Competencies

  • Biotransformations
  • Distillations
  • Complex multi-step synthesis
  • High-quality intermediates and bulk actives
  • Low volume, highly complicated chemistries

Capabilities/Equipment Overview

Buchs offers a broad range of multi-purpose manufacturing capabilities and is a proven contract manufacturing (CMO) partner that accelerates the development process.

  • Over 30 vessels, up to 1,600 L capacity
  • Temperature range: -65 to +225 °C
  • Three rotary evaporators (50 L)
  • Three centrifuges (1 stainless steel, 2 Hastelloy®)
  • Two distillation stills (100 and 250 L)
  • Two thin-film evaporators
  • Reactor capacity from 5 to 400 gallon (20 L - 1,600 L) glass-lined and Hastelloy
  • Small-scale chiral (SMB) separation unit
  •  Flow Chemistry synthesis

Chemistry Development Services

Buchs chemists are known for their ability to solve chemistry challenges and develop efficient chemical processes that support customers programs. Comprehensive development services include:

  • Seven Ph.D. process development chemists
  • Specialized technologies proven to reduce development times
        - Chem-EYE (FT-IR in-line monitoring system)
        - Automated lab reactors
        - Micro-reactor technology
        - SMB capabilities
  • Proficiency in scaling-up processes targeted for large-scale manufacturing

Virtual Tours

Large Scale Organic

Quality Control

Medium Scale Organic

cGMP Manufacturing

Process Development

Core Expertise Chart

Manufacturing expertise combined with our dedicated, highly skilled development, production and analytical teams provides our customers with speed and solutions to their everyday needs. Our chemists are experts at scale-up procedures, optimizing production schemes, and streamling production processes providing total manufacturing flexibility.

  50–200 GA
(200–800 L)
>200–500 GA
(>800–2,000 L)
>500–2,000 GA
(>2,000–8,000 L)
>2,000 GA
(>8,000 L)
Acetylation
   
Acid chloride chemistry    
Acrylation    
Acylation    
Aldol condensation    
Alkoxylation    
Alkylation    
Amidation    
Amination    
Benzoylation    
Bromination    
Carboxylation    
Chiral technologies    
Chlorination    
Chlorosulfonation    
Claisen condensation    
Condensation    
Cryogenic reactions    
Cyclization    
Dealkylation    
Dehalogenation    
Dehydrogenation    
Dehydrohalogenation    
Diazotization    
Diels-Alder reactions    
Distillation services    
Esterification    
Etherification    
Formylation    
Friedel-Crafts reactions    
Grignard reactions    
Halogenation    
Hydrogenation    
Nitration    
Organometallic reactions    
Oxidation    
Phosgenation    
Reduction, chemical    
Sandmeyer reaction    
Saponification    
Silylation reactions    
Sulfonation    
Wittig reactions    
Contact Facility

Facility Address:
Quality Manager
Industriestrasse 25
9470 Buchs
Switzerland
Swiss Free Call: 0800 80 00 80
Tel: +41 (0) 81 755 27 32
Fax: +41 (0) 81 755 27 70

Request a Site Audit

Reach out directly to our team here to process / schedule your site audit.