GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber

GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber

Conditions

sample/matrix 2 mL water + sodium chloride at 25% (pH 11) containing each analyte at 5 ppm, in a 4 mL vial
desorption process 250 C for 3 min
extraction heated headspace, 60 C for 5 min
SPME fiber 85 µm Polyacrylate (57304)
column VOCOL, 10 m x 0.20 mm I.D., 1.2 µm (24129-U)
oven 40 C (0.75 min), 20 C/min to 200 C (10 min)
carrier gas helium, 35 cm/sec @ 40 C
injection 5:1 split
liner 0.75 mm I.D. SPME type
inj. temp. 250 C
detector FID

Description

Categories Analytical Chromatography, SPME Applications, GC Applications, Solvents
Featured Industry Pharmaceutical (small molecule)
Legal Information VOCOL is a registered trademark of Sigma-Aldrich Co. LLC
suitability application for SPME, application for GC

Analyte

  • 1,2-Dimethoxyethane
  • 1,4-Dioxane
  • 2-Ethoxyethanol
  • 2-Methoxyethanol
  • Acetonitrile
  • Chlorobenzene
  • Chloroform
  • cis-1,2-Dichloroethylene
  • Cyclohexane
  • Dimethylacetamide
  • Dimethylformamide (DMF)
  • Hexane
  • Methanol
  • Methyl butyl ketone
  • Methylcyclohexane
  • Methylene chloride
  • m-Xylene
  • Nitromethane
  • N-Methylpyrrolidone
  • o-Xylene
  • p-Xylene
  • Pyridine
  • Sulfolane
  • Tetralin
  • Toluene
  • Trichloroethene

Materials

     
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