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Medication Monitoring Testing

Prescription monitoring requires accurate reference standards to ensure consistent and reliable results for drug confirmation and monitoring compliance.

Sigma-Aldrich's Cerilliant brand offers the widest selection of Certified Spiking Solutions® for prescription monitoring and pain management testing. These certified reference solutions are suitable for use in LC/MS or GC/MS laboratory testing by spiking into the matrix of choice such as urine or blood.

Sigma-Aldrich's Cerilliant brand also offers a full line of certified, NIST-traceable ethanol reference standards for alcohol testing in addition to over 900 other therapeutic and illicit drugs, metabolites and impurities (native and stable-isotope labeled).

Cerilliant Snap-N-Spike® solutions are produced and certified to the highest industry standards including ISO Guide 34 and ISO/IEC 17025 and are classified as "Certified Reference Materials" in accordance with ISO requirements. These reference standards are DEA-exempt allowing domestic laboratories to place an order without DEA paperwork. Most products have TK#s for shipment into Canada without Health Canada paperwork. Rigorous testing, from concentration certification to accelerated and real times studies, ensures solution accuracy and shelf life not only for long-term storage but also for short-term transport from Cerilliant to your location as well as normal lab use.

Cerilliant Snap-N-Spike® certified solution standards are supported by a comprehensive Certificate of Analysis (COA) which provides all analytical data from full neat material characterization and solution standard verification to uncertainty and traceability information to support your laboratory’s regulatory requirements.

Amphetamines-weight loss drugs

Sigma-Aldrich's Cerilliant brand provides the widest selection of Certified Spiking Solutions® for amphetamines and weight loss drugs including native and stable-labeled analogs of amphetamine, methamphetamine, phenyl and benzyl piperazines, MDA, MDMA, ephedrine, cathinones and bath salts. These certified reference solutions are gravimetrically prepared using precision balances that have been qualified to ensure minimal uncertainty, flame sealed under argon into ampoules for long term shelf life and are rigorously tested to ensure accuracy and shelf life through accelerated and real time studies.

Cerilliant reference solutions are manufactured and certified to the highest industry standards including ISO Guide 34, ISO 13485 and ISO/IEC 17025. Each certified reference standard is supported by a comprehensive Certificate of Analysis (COA) that provides all analytical data and uncertainty and traceability information to support regulatory requirements. Our COA includes analytical data on homogeneity and accuracy of concentration by comparison to an independently prepared calibration curve.

Anticonvulsants-antiepileptics

Sigma-Aldrich's Cerilliant brand offers certified Snap-N-Spike® solutions of second-generation and newer anticonvulsants used in the treatment of fibromyalgia, neuropathic pain, and migraines. These Certified Spiking Solutions® are suitable for numerous applications in pain management or medication monitoring including for use as calibrators and controls or for quantitation of patient drug levels by GC/MS or LC/MS. For anticonvulsant drugs listed as controlled substances by US DEA, we supply DEA-exempt solutions as an added convenience. In addition to second-generation and newer anticonvulsants and their internal standards, we also offer Certified Spiking Solutions® of other antiepileptic drug classes including benzodiazepines, barbiturates, hydantoins, and GABA analogs as well as their metabolites and internal standards.

Cerilliant Snap-N-Spike® reference solutions are manufactured and tested to the highest industry standards including ISO Guide 34 and ISO/IEC 17025. Preparation of our certified reference solutions begins with full characterization of neat materials, including determination of chromatographic purity, residual solvent, residual water, and inorganic content to determine proper weighing adjustments which is critical to accuracy and lot-to-lot consistency. Solutions are gravimetrically prepared using precision balances which have been qualified to ensure minimal uncertainty, flame sealed under argon into ampoules for long term shelf life and rigorously tested to ensure accuracy and shelf life through accelerated and real time studies.

We include with each product a comprehensive Certificate of Analysis (COA) that provides all analytical data on homogeneity, accuracy of concentration as compared to a calibration curve, and uncertainty and traceability information for regulatory requirements.

Antidepressants

Sigma-Aldrich's Cerilliant brand offers the widest selection of Certified Spiking Solutions® for antidepressants and their metabolites and stable-labeled internal standards including a comprehensive list of tricyclic and tetracyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). Cerilliant reference standards are manufactured and certified to the highest industry standards including ISO Guide 34 and ISO/IEC 17025. Each Certified Spiking Solution® is supported by a comprehensive Certificate of Analysis (COA) which provides all analytical data and uncertainty and traceability information to support regulatory requirements.

Antipsychotics

In 2011, 54 million prescriptions were filled for antipsychotics representing a 2.4% increase over the previous year according to the market research firm IMS Health.1 Antipsychotics are a class of drugs prescribed for treatment of serious psychiatric disorders such as schizophrenia, bipolar disorder, and major depression disorder. Antipsychotics are separated into two classes - older first generation drugs known as typicals and newer second generation drugs called atypicals. Both typical and atypical antipsychotics have serious adverse effects associated with their use including rapid weight gain, diabetes, cardiovascular disease, and movement impairment. Since many antipsychotics, especially the older typicals, have a narrow therapeutic window, therapeutic drug monitoring (TDM) is required to ensure patients remain within the drug’s optimal dosing range.

Sigma-Aldrich's Cerilliant brand offers the widest selection of Certified Spiking Solutions® for antipsychotics as well as their metabolites and stable-labeled internal standards. Our product listing includes older typical antipsychotics such as haloperidol, fluphenazine, thioridazine, and chlorpromazine as well as newer atypical antipsychotics from aripiprazole, clozapine, iloperidone, and olanzapine to paliperidone, lurasidone, quetiapine, risperidone and ziprasidone.

Cerilliant reference standards are manufactured and certified to the highest industry standards including ISO Guide 34, ISO/IEC 17025, and ISO 13485. Each Certified Spiking Solution® is supported by a comprehensive Certificate of Analysis (COA) that provides all analytical data and uncertainty and traceability information to support regulatory requirements.

Barbiturates

Sigma-Aldrich's Cerilliant brand provides a wide selection of Certified Spiking Solutions® for barbiturates and their stable-labeled internal standards. Since barbiturates are classified as controlled substances, we supply our barbiturate certified reference standards as DEA-exempt solutions for added convenience. Our Snap-N-Spike® reference solutions are certified to the highest industry standards including ISO Guide 34, ISO/IEC 17025 and ISO 13485. We provide a comprehensive Certificate of Analysis (COA) with each product that includes all analytical data on homogeneity, accuracy of concentration as compared to a calibration curve, and uncertainty and traceability information to support regulatory requirements.

Benzodiazepine standards

Benzodiazepines are a broad class of psychoactive drugs prescribed worldwide for treating numerous conditions from anxiety, seizures, and insomnia to muscle spasms, epilepsy, and alcohol withdrawal.1 Benzodiazepines are often combined into potentially lethal drug mixes by individuals with addiction disorders. Consumption of these drug mixes is associated with higher risk of overdose and mortality.2 Within the past several years, novel “designer” benzodiazepines such as phenazepam, etizolam, and nimetazepam have emerged in illicit online drug stores. Designer benzodiazepines are purportedly more potent than pharmaceutical benzodiazepines and are currently uncontrolled in many countries.3

Sigma-Aldrich's Cerilliant brand offers the widest selection of Certified Spiking Solutions® for benzodiazepines and their stable-labeled internal standards including a comprehensive list of parent compounds from alprazolam to triazolam in addition to a full offering of amino, hydroxyl, and glucuronide metabolites, and their internal standards. These certified reference solutions are suitable for numerous applications such as forensic analysis, clinical toxicology, urine drug testing, pharmaceutical research, or isotope dilution methods. Since these chemicals are generally controlled, Cerilliant supplies its Certified Spiking Solutions® of benzodiazepines in a USDEA and Health Canada with Test Kit Numbers (TK#s)-exempt solution format.

NSAIDs

Sigma-Aldrich's Cerilliant brand provides certified solution standards of several NSAIDs commonly used for the management of pain including ibuprofen and naproxen. Our certified reference solutions offer significant benefits to the laboratory such as increased efficiency, convenience of use with Snap-N-Spike® or Snap-N-Shoot® capability, and retest/expiration dates supported by real time stability data. Solutions are gravimetrically prepared using precision balances which have been qualified to ensure minimal uncertainty and are flame sealed under argon into ampoules for long term shelf life.

Cerilliant certified solution standards are manufactured and tested to the highest industry standards including ISO Guide 34 and ISO/IEC 17025. Our comprehensive data package includes a complete Certificate of Analysis (COA) which provides all analytical data on homogeneity, accuracy of concentration as compared to a calibration curve, short-term stability results in support of shipping requirements, and uncertainty and traceability information for audits.

Opiate Standards

Over the last decade, the prevalence of nonmedical prescription opioid and opiate use has increased worldwide and is the primary contributor to the global number of drug-related deaths. In the United States, deaths from misuse of prescription opioids have quadrupled and now exceed the number of motor-vehicle accident and suicide-related fatalities as well as deaths attributed to heroin and cocaine use combined.1 Within Europe, Asia, and Canada, increasing misuse of prescription opioids has also been observed.2

Since opiates are classified as controlled substances, we supply most opiate reference standards as USDEA and Health Canada (with TK#s)-exempt solutions for added convenience. Cerilliant reference standards are manufactured and certified to the highest industry standards including ISO Guide 34, ISO/IEC 17025 and ISO 13485. Each Certified Spiking Solution® is supported by a comprehensive Certificate of Analysis (COA) which provides all analytical data and uncertainty and traceability information to support regulatory requirements. Visit Cerilliant.com or call 800/848-7837 for more information.

Skeletal Muscle Relaxants

Sigma-Aldrich's Cerilliant brand provides certified Snap-N-Spike® solutions of several commonly-used skeletal muscle relaxants including baclofen, cyclobenzaprine, carisoprodol, meprobamate and metaxalone as well as their stable-labeled internal standards. Preparation of Cerilliant certified Snap-N-Spike® solutions begins with full characterization of neat materials, including determination of chromatographic purity, residual solvent, residual water, and inorganic content to determine proper weighing adjustments which is critical to accuracy and lot-to-lot consistency. Solutions are flame sealed under argon into ampoules for long term shelf life and rigorously tested to ensure accuracy and shelf life through accelerated and real time studies.

Cerilliant Snap-N-Spike® reference solutions are manufactured and tested to the highest industry standards including ISO Guide 34, ISO 13485, and ISO/IEC 17025. We include with each product a comprehensive Certificate of Analysis (COA) that provides all analytical data on homogeneity, accuracy of concentration as compared to a calibration curve, and uncertainty and traceability information for regulatory requirements.

Materials

     
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