Vitamins

Sigma-Aldrich's Cerilliant brand provides certified Snap-N-Spike® | Snap-N-Shoot® solutions of numerous vitamins from the B, A, K and E groups to vitamin D including 25-Hydroxy and 1,25-Dihydroxy analogs. These certified, NIST-traceable solutions are suitable for use as starting materials in preparation of matrix-based calibrators and controls for clinical applications or in dietary supplement analytical testing methods.

Handling and preparation of reference solutions of vitamins present significant challenges to the laboratory due to their sensitivity to air, light, and solution pH. Preparation of Cerilliant certified reference solutions begins with full characterization of neat materials, including determination of chromatographic purity, residual solvent, residual water, and inorganic content to determine proper weighing adjustments which is critical to accuracy and lot-to-lot consistency. Cerilliant’s validated process includes manufacturing controls for sensitive compounds such as raw material handling and solution preparation under inert conditions and flame-sealing of ampoules under argon to minimize degradation and promote long-term shelf life.

Certified concentration values for each vitamin reference solution improve laboratory efficiency from less time weighing sensitive powders and preparing stock solutions to rerunning samples or remaking stocks due to possible differences in raw material purity factors. Solutions are gravimetrically prepared using precision balances which have been qualified to ensure minimal uncertainty. The convenient 1 mL unit size minimizes waste and additional storage of sensitive vitamins in solution under non-inert environments.

Rigorous testing, from concentration certification to accelerated and real-time studies, ensures solution accuracy and shelf life not only for long-term storage but also for short-term transport from Cerilliant to the end user as well as normal lab use. Cerilliant Snap-N-Spike® | Snap-N-Shoot® certified solution standards are supported by a comprehensive Certificate of Analysis (COA) which provides all analytical data from full neat material characterization and solution standard verification to uncertainty and traceability information to meet laboratory regulatory requirements. Cerilliant certified reference solutions are prepared and certified to the highest industry standards including ISO Guide 34, ISO 17025 and ISO 13485 and are compliant with ISO 17511 and ISO 15194.

Materials

     
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