Hepatocyte Growth Factor (HGF)

By: Jennifer Fries, BioFiles 2009, 4.5, 12.

Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis. HGF is the ligand for a receptor encoded by the c-met proto-oncogene. c-Met expression has been observed in tumors from many sources, including stomach, lung, breast, kidney colon, liver, and melanoma, and is associated with tumor progression and metastasis.

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Hepatocyte Growth Factor (HGF)

Product Description Source Recombinant Host Physical Form Assay Cell Type Affected Cat. No.
Hepatocyte Growth Factor human Baculovirus infected High-5 cells lyophilized powder The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5. renal tubular epithelial cell hepatocyte epidermal keratinocyte epidermal keratinocyte H1404-5UG
Hepatocyte Growth Factor human mouse NSO cells lyophilized powder The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5. hepatocyte epidermal keratinocyte renal tubular epithelial cell epidermal melanocyte H9661-5UG

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Materials

     

References

  1. Birchmeier, C., et al., Met, metastasis, motility, and more. Nat. Rev. Mol. Cell Biol. 4, 915-925 (2003).
  2. Ma, P.C., et al., c-Met: structure, functions and potential for therapeutic inihibition. Cancer Metastasis Rev. 22, 309-325 (2003).
  3. Zhang, Y.W., and Vande Woude, G.F., HGF/SF-met signaling in the control of branching morphogensis and invasion. J. Cell Biochem. 88, 408-417 (2003).

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