Plasma Derived Proteins and Enzymes

BioFiles 2006, 1.5, 2.

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,000 different proteins from about 500 gene products. Sigma-Aldrich has been isolating and purifying plasma and blood derived proteins for more than 40 years. As an original manufacturer, we offer the world's largest portfolio of proteins for research applications. Many of these proteins are produced on a large-scale custom basis under GMP for our manufacturing customers. For more extensive information on individual products and additional technical resources on plasma and blood related proteins and enzymes visit the Enzyme Explorer at sigma-aldrich.com/enzymeexplorer.


Plasma Protein Composition


Protein Amount in Normal Plasma (mg/100 mL)
α1-Acid glycoprotein 55–140
Albumin 3500–5000
α1-Antichymotrypsin 30–60
Antihemophilic factor (Factor VIII) (1–2)
Antithrombin III (20–40)
α1-Antitrypsin 200–400
Basic protein B1
Basic protein B2 <1
γ Bence Jones protein Trace
κ Bence Jones protein Trace
Ceruloplasmin 15–60
Cholinesterase 0.5–1.5
Complement C1 Esterase inhibitor 15–35
Complement C1r Component
Complement C4 Binding Protein
Complement C8 Component 8
Complement C9 Component 23
Complement Factor B
Complement Factor D
Complement Factor H
Complement C1q Component 10–25
Complement C1s Component 1–2
Complement C3 Component 55–120
Complement C4 Component 20–50
Complement C6 Component 7
Complement C2 Component 2–3
Complement C5 Component 4–15
Complement C7 Component 6
C-Reactive Protein <1
α1-Fetoprotein ~1μg
Fibrinogen 200–450
Fibrin-stabilizing factor (Factor XIII) (1–4)
Fibronectin 25–40
Galactoglycoprotein
GC Globulin 20–55
0.6 S γ2-Globulin <1
2 S γ2-Globulin 0.1
3.1 S Leucine-rich α2-glycoprotein 2–3
3.8 S Histidine-rich α2-glycoprotein 5–15
4 S α2, β1-Glycoprotein Trace
8 S α3-Glycoprotein 3–5
Zn-α2-Glycoprotein 2–15
α1B-Glycoprotein 15–30
α1T-Glycoprotein 5–12
α2HS-Glycoprotein 40–85
9.5 S α1-Glycoprotein (serum amyloid P protein) 3–8
β2-Glycoprotein I 15–30
β2-Glycoprotein II 12–30
β2-Glycoprotein III 5–15
Haptoglobin Type 2–1 160–300
Haptoglobin Type 1–1 100–220
Haptoglobin Type 2–2 120–260
Hemopexin 50–115
Immunoglobulin A 90–450
Immunoglobulin D <15
Immunoglobulin E <0.06
Immunoglobulin G 800–1800
Immunoglobulin M 60–250
Inter-α-trypsin inhibitor 20–70
Lysozyme 0.5–1.5
α2-Macroglobulin 150–420
α1-Microglobulin 4–9
β2-Microglobulin Trace
Plasminogen (6–25)
Post γ-globulin
Prealbumin, thyroxine-binding 10–40
Pregnancy-associated 2-glycoprotein Trace
Properdin 2–3
Prothrombin (5–10)
Retinol-binding protein 3–6
Thyroxine-binding globulin 1–2
Transcortin ~7
Transferrin 200–320

From “The Plasma Proteins”, Volume IV, 2nd Edition, 1984, Frank W. Putnam.

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