Highly Acid-Labile Resins for the Synthesis of Protected Peptide Carboxamides

ChemFiles Volume 3 Article 4


This extremely acid-labile resin provides Fmoc-/tBu-protected peptide amides by treatment with low concentrations of TFA (~ 1%).(1-2) Reductive alkylation of this support followed by acylation gives access to secondary carboxamide products.(3)

back to top 

Materials

     

References

  1. Albericio, F.; Barany, G. Int. J. Pept. Protein Res. 1987, 30, 206.
  2. Albericio, F. et al. J. Org. Chem. 1990, 55, 3730.
  3. Songster, M. F. et al. Lett. Pept. Sci. 1995, 2, 265.

back to top 

Related Links

Categories