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MRT - Grignard Reaction

By: Matthias Junkers, Aldrich ChemFiles 2009, 9.4, 15.

Aldrich ChemFiles 2009, 9.4, 15.

Benefit from MRT & Flow Chemistry: cost savings combined with accelerated & economic process development for large scale synthesis.

Microreactors also have some simple pragmatic advantages over traditional batch vessels: they take up less space on the factory floor and yet can still be used to make large quantities of product. 2-Benzoyl pyridine is an important building block, with an annual demand of about 15 tons. It is synthesized through a Grignard reaction (Scheme 9), and in a microreactor, this takes less than a minute. The Grignard microreaction is followed by two online quench modules. Precise reaction control leads to a highly pure product making a distillation step unnecessary that is needed for purification of the lower quality batch product.

Scheme 9: Grignard microreaction with two subsequent quench modules

The flow process was first developed with the Sigma-Aldrich Microreactor Explorer Kit (19979) using a 2 mL glass microreactor, which is able to produce up to 1 kg of 2-benzoyl pyridine per day. In a pilot study for the transfer of microreactor technology into large scale production we could show that process economic parameters evaluated with the Sigma-Aldrich Microreactor Explorer Kit (19979) ccould be directly transferred to production in a stainless steel Alfa Laval Art® plate reactor. Thus the rapid flow rates that can be achieved with this reactor allows the continuous production of 200 to 300 of kg 2-benzoyl pyridine per day. All of this from a reactor that requires only 30 x 50 cm of bench space!

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