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Negishi Coupling

By: Josephine Nakhla, Chemfiles Volume 10 Article 4

The cross-coupling of organozincs with organic electrophiles in the presence of a transition-metal catalyst (Scheme 3), is widely utilized due to the mild, yet reactive nature of organozinc halides.

Scheme 3: The Negishi reaction

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  1. Yet, Larry. Negishi Cross-Coupling Reaction. Name Reactions for Homologations. John Wiley & Sons, Inc. (2009), (Pt. 1), 70–99.

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