Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Negishi Coupling

By: Josephine Nakhla, Chemfiles Volume 10 Article 4

The cross-coupling of organozincs with organic electrophiles in the presence of a transition-metal catalyst (Scheme 3), is widely utilized due to the mild, yet reactive nature of organozinc halides.

Scheme 3: The Negishi reaction

back to top

References

  1. Yet, Larry. Negishi Cross-Coupling Reaction. Name Reactions for Homologations. John Wiley & Sons, Inc. (2009), (Pt. 1), 70–99.

back to top

Related Links