Olefin Metathesis

ChemFiles Volume 11 Article 1

Employing the second generation Grubbs catalyst (2 mol %) a variety of lypophillic substrates successfully undergo ring-closing or cross-metathesis in water at room temperature to produce high isolated yields of the desired products (Scheme 1). Reactions were conducted in 2.5% TPGS- 750-M/water, with yields equal to or slightly better than those performed using various other surfactant-water combinations.

Scheme 1 Selected olefin metathesis.

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