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Potassium Trifluoroborates

Chemfiles Volume 4 Article 2

Alkyl, aryl, and alkenyl trifluoroborate salts are compelling alternatives to boronic acids in Suzuki–Miyaura coupling and in rhodium catalyzed carbon-carbon bond forming reactions. These salts are air and water stable, and in many cases eliminate the need to add either additional ligands or base for cross coupling.

Whereas the boronic acids readily form cyclic anhydrides, these new salts do not form unwanted side products. In many cases, the trifluoroborate salt is more efficient and tolerant to functional groups than the corresponding boronic acids.

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