Trityl Resins

ChemFiles Volume 3 Article 4

PRODUCTS: 93003, 69516, 65374

Trityl chloride resins and as 4-methyl- and 4-methoxytrityl derivatives render increased acid lability, making them less favorable for stable attachment of C-terminal carboxylic acid during peptide synthesis.(1)  In SPPS and SPOS, the immobilization of other functionalities like amines, alcohols, hydroxylamines, hydrazines, or thiols are described; e.g. N-α-amino groups and N-ε-amino groups of lysine are used in anchoring protected peptide segments.(2)

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  1. Barlos, K. et al. Tetrahedron Lett. 1989, 30, 3943.
  2. Barlos, K. et al. Peptides 1992, Proc. 23rd Eur. Pept. Symp. C. H. Schneider, A. N. Eberle, Eds, ESCOM: Leiden 1993; p. 281.

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