Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Wang resins Preloaded with N-α-Fmoc-Protected Amino Acids B

Chemfiles Volume 3 Article 4


TFA-labile Wang resins are standard supports for batch synthesis of peptide acids following the Fmoc-/tBu-protection scheme.(1,2) The Fmoc-amino acids are coupled to the 4-hydroxymethylphenoxyacetic acid linkers in such a way that epimerization and dipeptide formation are minimized. Our preloaded Wang resins are high-quality supports, which enable you to start directly with automated protocols. The polymer matrix for our preloaded Wang resins is polystyrene cross-linked with 1% DVB.

back to top 

Materials

     

References

  1. Wang, S. S. J. Am. Chem. Soc. 1973, 95, 1328.
  2. Guy, C. A.; Fields, G. B. Methods Enzymol., Vol. 289 (Solid-Phase Peptide Synthesis), G. Fields, B. ed.; Academic Press: San Diego, 1997, 29.

back to top 

Related Links